Results 131 to 140 of about 106,553 (247)
Point of care tests for tuberculosis (TB) : economic analysis report [PDF]
A number of clinical/disease areas have been prioritised by the TSB and DH for the DIIA Innovation Platform. To support commissioning of technology developments in the area of tuberculosis detection in humans, a scoping review has been undertaken to help
Osipenko, Leeza, Szczepura, Ala
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Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions
MedComm, Volume 7, Issue 3, March 2026.Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song +10 more
wiley +1 more source
Two-Component Systems of Mycobacterium tuberculosis as potential targets for drug development [PDF]
, 2014 Tuberculosis, caused by Mycobacterium tuberculosis, is a global health problem with approximately two million deaths every year. Furthermore, up to one-third of the world population is infected with latent form of this bacterium.Existing anti ...
Marszalek, Marta +2 more
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CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.ABSTRACT The purpose was to evaluate retrieval‐augmented generative (RAG) artificial intelligence (AI) methods for assessing the regulatory compliance of drug information and adherence to best practices in clinical trial protocols. Integrated systems containing RAG and large language model (LLM) components were employed to evaluate drug information and
Shreyas Waikar +2 more
wiley +1 more source
Latent Adolescent Pulmonary Tuberculosis [PDF]
BMJ, 1936 R C, Wingfield, A M, Macpherson
openaire +2 more sources
Vaping and Tuberculosis: An Overlooked Risk in High‐Burden South Asian Countries
Public Health Challenges, Volume 5, Issue 1, March 2026.ABSTRACT Tuberculosis (TB) is an infectious disease that remains one of the most pressing threats to public health, especially in South Asian countries. Despite being curable, it is a major cause of morbidity and mortality, driven by factors such as poverty, lack of nutrition, HIV infection, and overcrowding of individuals.
Hafsa Ali +4 more
wiley +1 more source
Design of Bayesian Clinical Trials With Clustered Data
Statistics in Medicine, Volume 45, Issue 6-7, March 2026.ABSTRACT In the design of clinical trials, it is essential to assess the design operating characteristics (e.g., power and the type I error rate). Common practice for the evaluation of operating characteristics in clinical trials that employ Bayesian analysis and decision procedures relies on estimating the sampling distribution of posterior summaries ...
Luke Hagar, Shirin Golchi
wiley +1 more source
Biofilm Associated Persistence and Drug Tolerance in Mycobacteria Within Host Microenvironments
APMIS, Volume 134, Issue 3, March 2026.ABSTRACT Biofilms formed by mycobacteria, particularly Mycobacterium tuberculosis (Mtb), represent a major challenge in tuberculosis (TB) treatment due to their highly organized structure and their capacity to induce phenotypic drug tolerance. These three‐dimensional bacterial aggregates are embedded in a self‐produced extracellular matrix that ...
Lourdes Serrano Garcia +3 more
wiley +1 more source
The Clinical Respiratory Journal, Volume 20, Issue 3, March 2026.This study identifies D‐dimer as a key mediator between lymphocyte depletion and pulmonary tuberculosis dissemination. Our findings reveal that reduced lymphocyte counts increase dissemination risk partly by elevating D‐dimer levels, suggesting a critical link between immune deficiency and coagulopathy.
Yujun Lin +4 more
wiley +1 more source