Results 101 to 110 of about 53,392 (269)

Identification of ferroptosis-related gene signature for tuberculosis diagnosis and therapy efficacy

iScience
Summary: Diagnosis of tuberculosis remains a challenge when microbiological tests are negative. Immune cell atlas of patients with tuberculosis and healthy controls were established by single-cell transcriptome.
Bingfen Yang, Fei Zhai, Zhimin Li, Xinjing Wang, Xianping Deng, Zhihong Cao, Yanhua Liu, Ruo Wang, Jing Jiang, Xiaoxing Cheng   +9 more
doaj   +1 more source

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas, Baerbel Rotthaeuser, Niels Porksen, Pascale Labard, My‐Liên Nguyên‐Pascal, Mathieu Coudert, Baptiste Berthou, Marie Baccara‐Dinet, Gabor Boka, Mark Peakman, Felix Reschke, Michael J. Haller   +11 more
wiley   +1 more source

Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection

, 2011
The aim of this project was to compare the breadth and magnitude of CFP10 and ESAT6-specific CD8 T cell responses in individuals with latent Mycobacterium tuberculosis (MTB) infection (LTBI) and active TB disease, and further define MTB-specific CD8 T ...
Moshi, Noell Dominika
core  

CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis. [PDF]

, 2009
BACKGROUND Leucocyte activating chemokines such as CCL2, CCL3, and CXCL8 together with proinflammatory IFNgamma, TNFalpha and downmodulatory IL10 play a central role in the restriction of M.
Hussain Rabia, Cliff, Jacqueline M., Hasan, Z, Jamil, Bushra, Bushra Jamil, Hussain, Rabia, Cliff, Jacqueline M, Ashraf Mussarat, Hazel M Dockrell, Hasan Zahra, Jamil, B, Mussarat Ashraf, Jacqueline M Cliff, Ashraf, Mussarat, Cliff Jacqueline M., Cliff, JM, Irfan, Muhammad, Irfan Muhammad, Ashraf, M, Hussain, R, Muhammad Irfan, Hasan, Zahra, Dockrell Hazel M., Dockrell, HM, Irfan, M, Jamil Bushra, Dockrell, Hazel M, Rabia Hussain, Zahra Hasan   +28 more
core   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Systemic Treatment and Outcome in Erythrodermic Psoriasis: A Retrospective Multicenter Study

International Journal of Dermatology, EarlyView.
This multicentre real‐world study illustrates the heterogeneity of systemic treatment approaches in erythrodermic psoriasis (EP) in Bavaria, Germany. Adverse events were more frequently observed with conventional therapies, whereas biologic therapies showed favorable outcomes.
Julian Kögel, Sandra Schuh, Julia Welzel, Michael Sticherling, Lukas Sollfrank, Carola Berking, Teodora Pumnea, Valerie Glatzel, Lars French, Felix Lauffer, Martin Valentin Vitus, Tilo Biedermann, Susanne Bauer, Michael Spindler, Mark Berneburg, Dennis Niebel   +15 more
wiley   +1 more source

Prevalence and exposure variables of latent infection by mycobacterium tuberculosis in healthcare workers [PDF]

Revista Brasileira de Enfermagem
Objectives: To identify in the scientific literature the prevalence, diagnostic methods, and exposure variables of latent infection by Mycobacterium tuberculosis in healthcare workers. Methods: An integrative review of the scientific literature based on
Raphael Sampaio dos Santos, Katerine Moraes dos Santos, Angela Maria Mendes Abreu, Cristiane Cardoso de Paula, Regina Célia Gollner Zeitoune   +4 more
doaj   +1 more source

Early On‐Treatment Change in SALT as a Pragmatic Predictor of Ritlecitinib Response in Moderate‐To‐Severe Alopecia Areata: A Real‐World Cohort Study

International Journal of Dermatology, EarlyView.
Ritlecitinib induced rapid clinical improvement in moderate‐to‐severe alopecia areata in real‐world practice. Early change in SALT at Week 12 strongly discriminated Week‐24 responders, supporting a pragmatic treat‐to‐target checkpoint, alongside improvements in clinician‐reported and patient‐reported outcomes and a favorable safety profile.
Giuseppe Gallo, Isotta Giunipero di Corteranzo, Pietro Quaglino, Simone Ribero, Francois Rosset   +4 more
wiley   +1 more source

Point of care tests for tuberculosis (TB) : economic analysis report [PDF]

A number of clinical/disease areas have been prioritised by the TSB and DH for the DIIA Innovation Platform. To support commissioning of technology developments in the area of tuberculosis detection in humans, a scoping review has been undertaken to help
Szczepura, Ala, Osipenko, Leeza
core  

Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities

, 2012
Tuberculosis is unique among the major infectious diseases in that it lacks accurate rapid point-of-care diagnostic tests. Failure to control the spread of tuberculosis is largely due to our inability to detect and treat all infectious cases of pulmonary
Grobusch, Martin P., Pletschette, Michel, Mchugh, Timothy D., Schwank, Samana, Zumla, A, McNerney, R., Squire, S. Bertel, Ford, Nathan, Kim, P.S., Marais, B, Squire, S B, Migliori, Giovanni Batista, Bates, M, McHugh, Timothy D, Grobusch, M.P., McNerney, R, Migliori, G-B, Migliori, Giovanni-Batista, Squire, Bertie, Lawn, S, O'Grady, J, Chakaya, J., Lawn, Steve, Mwaba, Peter, Harari, Alexandre, Memish, Z, Harari, A., Cox, Helen, Abubakar, I, Ford, N, Hoelscher, Michael, Chakaya, J, Kim, Peter, Zijenah, L, Casenghi, M., Grobusch, M P, Casenghi, Martina, McHugh, T D, Marais, B., Weyer, K., Pantaleo, Giuseppe, Schito, Marco, Pletschette, M, Abubakar, Ibrahim, Atun, Rifat, Weyer, K, Mchugh, Timothy, O'Grady, J., Schwank, S, Mwaba, P., Grobusch, Martin P, Mwaba, P, Casenghi, M, Lawn, S., Squire, S, Zijenah, L., Ditui, Lucica, Cox, H., Pantaleo, G, Kim, P S, Schito, M, Weyer, Karin, O'Grady, Justin, Atun, R, Kim, Peter S, Harari, A, Grobusch, Martin, Abubakar, I., Zijenah, Lynn, Bates, Matthew, Memish, Ziad, Cox, H, Pletschette, M., Memish, Z., Schwank, S., Squire, S Bertel, Migliori, G.B., Ditui, L., McNerney, Ruth, Hoelscher, M., McHugh, T.D., Bates, M., Swaminathan, Soumya, Marais, Ben, Maeurer, Markus, Pantaleo, G., Zumla, A., Maeurer, M, Swaminathan, S, Kim, Peter S., Ditui, L, Hoelscher, M, Squire, S.B., Chakaya, Jeremiah, Ford, N., Zumla, Alimuddin, Schito, M., Maeurer, M., Swaminathan, S., Atun, R.   +99 more
core   +1 more source