Results 51 to 60 of about 876,155 (293)

Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Synaptic transmission involves the release of neurotransmitters that activate receptors on postsynaptic cells. The results reveal that protons fulfill the criteria for a neurotransmitter and that they activate postsynaptic acid-sensing ion channels. This activity facilitates synaptic plasticity, a requirement for learning
Jianyang, Du, Leah R, Reznikov, Margaret P, Price, Xiang-ming, Zha, Yuan, Lu, Thomas O, Moninger, John A, Wemmie, Michael J, Welsh   +7 more
openaire   +2 more sources

Hemispheric Lateralization of a Molecular Signal for Pain Modulation in the Amygdala

Molecular Pain, 2008
The extracellular signal-regulated kinase (ERK) cascade has been shown to be a key modulator of pain processing in the central nucleus of the amygdala (CeA) in mice. ERK is activated in the CeA during persistent inflammatory pain and this activation is both necessary and sufficient to induce peripheral tactile hypersensitivity.
Carrasquillo, Yarimar, Gereau, Robert W, IV   +1 more
openaire   +3 more sources

An adeno-associated viral vector transduces the rat hypothalamus and amygdala more efficient than a lentiviral vector

BMC Neuroscience, 2010
Background This study compared the transduction efficiencies of an adeno-associated viral (AAV) vector, which was pseudotyped with an AAV1 capsid and encoded the green fluorescent protein (GFP), with a lentiviral (LV) vector, which was pseudotyped with a
Vreugdenhil Erno, Garner Keith M, Luijendijk Mieneke CM, Brans Maike AD, Fitzsimons Carlos P, de Backer Marijke WA, Adan Roger AH   +6 more
doaj   +1 more source

Effective connectivity of the amygdala during the consumption of erotic, sexual humor, and monetary rewards with a DCM-PEB approach

PLoS ONE, 2022
While a large body of research exists on the processing of monetary rewards, less is known about sexual reward processing. This study aimed to identify effective connectivity for the consumption of sexual (erotic and sexual humor) and non-sexual ...
Yu-Chen Chan, Tai-Li Chou
doaj   +2 more sources

The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta, Augusto J. Mendes, Valentina Garibotto, Cecilia Boccalini, Aurelien Lathuiliere, Innocenzo Rainero, Elisa Rubino, Henrik Zetterberg, Nicholas J. Ashton, Federica Ribaldi, Giovanni B. Frisoni, for the Alzheimer's Disease Neuroimaging Initiative   +11 more
wiley   +1 more source

Synaptic correlates of associative fear memory in the lateral amygdala

Neuron, 2021
Successful adaptation to the environment requires an accurate response to external threats by recalling specific memories. Memory formation and recall require engram cell activity and synaptic strengthening among activated neuronal ensembles. However, elucidation of the underlying neural substrates of associative fear memory has remained limited ...
Dong Il, Choi, Jooyoung, Kim, Hoonwon, Lee, Ji-Il, Kim, Yongmin, Sung, Ja Eun, Choi, S Jayakumar, Venkat, Pojeong, Park, Hyunsu, Jung, Bong-Kiun, Kaang   +9 more
openaire   +2 more sources

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Tau-PET pathology in the subregions of the amygdala and its associations with cognitive performance and neuropsychiatric symptoms in autosomal dominant Alzheimer’s disease

Alzheimer’s Research & Therapy
Background The amygdala plays a role in behavior and emotional response and is vulnerable to Alzheimer’s disease (AD) pathology, yet little is known about amygdala tau accumulation before clinical symptom onset.
Catarina Tristão-Pereira, Stephanie Langella, Justin S. Sanchez, Vincent Malotaux, Bing He, Jorge Alcina, Jairo E. Martinez, Zoe Rubinstein, Ana Baena, Clara Vila-Castelar, Averi Giudicessi, Liliana Ramirez Gomez, Claudia Ramos, Daniel Vasquez, David Aguillon, Heidi I. L. Jacobs, Reisa A. Sperling, Keith Johnson, Jennifer R. Gatchel, Yakeel T. Quiroz   +19 more
doaj   +1 more source

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Preoperative amygdala fMRI in temporal lobe epilepsy [PDF]

, 2009
Purpose: Anterior temporal lobe resections (ATLR) benefit 70% of patients with refractory mesial temporal lobe epilepsy (TLE), but may be complicated by emotional disturbances.
Silvia B. Bonelli, Mahinda Yogarajah, Matthias J. Koepp, John S. Duncan, Mark R. Symms, Koepp, M.J., Robert Powell, Powell, R., Thompson, P. J., Duncan, J.S., Symms, M.R., Bonelli, S.B., Yogarajah, M., Pamela J. Thompson   +13 more
core   +1 more source