Results 81 to 90 of about 2,167,307 (320)

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Hypothalamic functional connectivity, depressive symptoms, and post-treatment SOREMPs in narcolepsy type 1: links to sleep latency and mediation mechanisms

Translational Psychiatry
Narcolepsy type 1 (NT1) is characterized by sleep-onset rapid eye movement periods (SOREMPs), reflecting dysregulated rapid eye movement (REM) sleep control.
Mengmeng Wang, Haodong Zhang, Xiaosong Dong, Fang Han, Fulong Xiao   +4 more
doaj   +1 more source

Organization of connections between the amygdala, medial prefrontal cortex, and lateral hypothalamus: a single and double retrograde tracing study in rats

Brain Structure and Function, 2015
The amygdala and medial prefrontal cortex (mPFC) are highly interconnected telencephalic areas critical for cognitive processes, including associative learning and decision making.
C. Reppucci, G. Petrovich
semanticscholar   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

GABAergic Projections from Lateral Hypothalamus to Paraventricular Hypothalamic Nucleus Promote Feeding

Journal of Neuroscience, 2015
Lesions of the lateral hypothalamus (LH) cause hypophagia. However, activation of glutamatergic neurons in LH inhibits feeding. These results suggest a potential importance for other LH neurons in stimulating feeding.
Zhaofei Wu, Eun Ran Kim, Hao Sun, Yuanzhong Xu, Leandra R. Mangieri, De-Pei Li, Hui-Lin Pan, Yong Xu, Benjamin R. Arenkiel, Qingchun Tong   +9 more
semanticscholar   +1 more source

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

Investigating the Reinforcing Effects of Optogenetic Stimulation of Lateral Hypothalamus Projections to the Laterodorsal Tegmental Nucleus and Pedunculopontine Tegmental Nucleus in Mice [PDF]

Previous studies have shown that in both mice and rats, glutamatergic inputs from the Laterodorsal Tegmental Nucleus (LDTg) to the Ventral Tegmental Area (VTA) result in rewarding effects.
Moghadam, Jacqueline
core   +1 more source

Hedonic Eating and the “Delicious Circle”: From Lipid-Derived Mediators to Brain Dopamine and Back

Frontiers in Neuroscience, 2018
Palatable food can be seductive and hedonic eating can become irresistible beyond hunger and negative consequences. This is witnessed by the subtle equilibrium between eating to provide energy intake for homeostatic functions, and reward-induced ...
Roberto Coccurello, Roberto Coccurello, Mauro Maccarrone, Mauro Maccarrone   +3 more
doaj   +1 more source

Increased Hypothalamic Projections to the Lateral Hypothalamus and Responses to Leptin in Rat Neonates From High Fat Fed Mothers

Frontiers in Neuroscience, 2020
The lateral hypothalamus (LHA) is a central hub in the regulation of food intake and metabolism, as it integrates homeostatic and hedonic circuits. During early development, maturing input to and output from the LHA might be particularly sensitive to ...
Lyla Kelley, Lyla Kelley, Silvanna Verlezza, Hong Long, Mary Loka, Mary Loka, Claire-Dominique Walker, Claire-Dominique Walker   +7 more
doaj   +1 more source

Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses

Nature Communications, 2015
The hypothalamic–pituitary–adrenal (HPA) axis functions to coordinate behavioural and physiological responses to stress in a manner that depends on the behavioural state of the organism.
P. Bonnavion, A. C. Jackson, M. Carter, L. de Lecea   +3 more
semanticscholar   +1 more source