Results 71 to 80 of about 2,167,307 (320)

Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]

, 2013
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Nunez, Cristina, Edina Zelei, M Victoria Milanés, Polyák, Ágnes, Zelei, Edina, Agnes Polyák, Krisztina J Kovács, Kovács, Krisztina J., Cristina Núnez, Milanes, Victoria M., Pintér-Kübler, Bernadett, Ferenczi, Szilamér, Bernadett Pintér-Kübler, Szilamér Ferenczi   +13 more
core   +3 more sources

Regulatory role of lateral hypothalamus hypocretin neurons-medial entorhinal cortex neural circuit in spatial memory in mice

陆军军医大学学报, 2023
Objective To explore the regulatory effects of hypocretin (Hcrt) neurons in lateral hypothalamus (LHHcrt)-medial entorhinal cortex (MEC) circuit on spatial memory.
LIAO Yixiang, ZHENG Ziyi, CHENG Xiaofang, CHENG Xiaofang, WEN Ruyi   +4 more
doaj   +1 more source

An Inhibitory Septum to Lateral Hypothalamus Circuit That Suppresses Feeding

Journal of Neuroscience, 2016
Feeding behavior is orchestrated by neural circuits primarily residing in the hypothalamus and hindbrain. However, the relative influence of cognitive and emotional brain circuits to the feeding circuitry in the hypothalamus and hindbrain remains unclear.
P. Sweeney, Yun-Lei Yang
semanticscholar   +1 more source

c-Fos expression in hypothalamus of fed and fasted mice.

, 2015
Typical photomicrographs of c-Fos expression in hypothalamus of fed mice (A) and fasted mice (C); Mean number of c-Fos-positive cells in hypothalamus of fed mice (B) and fasted mice (D). SR: SR 57227 (10 mg/kg, i.p.); On: ondansetron (3 mg/kg, i.p.). PVN:
Pu Wang (171923), Changhong Liu (519694), Bingjin Li (545408), Xingyi Zhang (545413), Yungang Luo (706022), Ranji Cui (545414), Dongyuan Shao (545409)   +6 more
core   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Medial septum glutamatergic neurons modulate nociception in chronic neuropathic pain via projections to lateral hypothalamus

Frontiers in Pharmacology, 2023
The medial septum (MS) contributes in pain processing and regulation, especially concerning persistent nociception. However, the role of MS glutamatergic neurons in pain and the underlying neural circuit mechanisms in pain remain poorly understood.
Bing-Qian Fan, Jun-Ming Xia, Dan-Dan Chen, Li-Li Feng, Jia-Hui Ding, Shuang-Shuang Li, Wen-Xian Li, Yuan Han   +7 more
doaj   +1 more source

Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits

Advanced Science, EarlyView.
This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou, Jianing Jing, Zhuohan Shi, Lei Sun   +3 more
wiley   +1 more source

Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry

Frontiers in Systems Neuroscience, 2015
The study of the neural bases of eating behavior, hunger, and reward has consistently implicated the lateral hypothalamus (LH) and its interactions with mesocorticolimbic circuitry, such as mesolimbic dopamine projections to nucleus accumbens (NAc) and ...
D. C. Castro, Shannon L. Cole, K. Berridge   +2 more
semanticscholar   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Interferon-alpha acts at the preoptic hypothalamus to reduce natural killer cytotoxicity in rats

, 1995
We previously demonstrated that an intracerebroventricular injection of recombinant human interferon-alpha (rhIFN-alpha) reduced the cytotoxicity of splenic natural killer (NK) cells in rats and mice.
T. Katafuchi, S. Take, D. Uchimura, T. Hori, Y. Kanemitsu   +4 more
core   +1 more source