Results 61 to 70 of about 2,167,307 (320)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Administração de MK-801 e CNQX na área hipotalâmica lateral e tubérculo olfativo e seus efeitos sobre a ingestão de alimentos em pombos (Columba livia) [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências BiológicasO presente trabalho teve como objetivo examinar os efeitos dos antagonistas de receptores glutamatérgicos ionotrópicos NMDA e AMPA-kainato sobre o consumo de ...
Silva, Amanda Alcaraz da
core  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Orexin modulates behavioral fear expression through the locus coeruleus

Nature Communications, 2017
Vigilance involves the activation of orexinergic neurons in the lateral hypothalamus (LH-ox). Here the authors report the functional role of a monosynaptically connected circuit with orexinergic neurons connected to noradrenergic neurons in the locus ...
Shingo Soya, Tohru M. Takahashi, Thomas J. McHugh, Takashi Maejima, Stefan Herlitze, Manabu Abe, Kenji Sakimura, Takeshi Sakurai   +7 more
doaj   +1 more source

Mediation of lateral hypothalamus orexin input to lateral habenula in the inhibitory effects of mechanical stimulation on psychomotor responses induced by cocaine

Frontiers in Molecular Neuroscience, 2023
IntroductionThe lateral hypothalamus (LH) plays an important physiological role in brain function and also plays an important role in substance abuse. The neuropeptides called orexin (or hypocretins) have been identified as being located exclusively in ...
Han Byeol Jang, Han Byeol Jang, DanBi Ahn, DanBi Ahn, Hyung Kyu Kim, Xiaowei Guan, Yu Fan, Bae Hwan Lee, Hee Young Kim   +8 more
doaj   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Whole-brain mapping of projection from mouse lateral septal nucleus

Biology Open, 2019
The lateral septal nucleus (LS) plays a critical role in emotionality, social behavior and feeding processes, through neural connections with the hippocampus and hypothalamus.
Ke Deng, Lu Yang, Jing Xie, He Tang, Gui-Sheng Wu, Huai-Rong Luo   +5 more
doaj   +1 more source

An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice

eLife, 2021
Understanding how neuronal circuits control nociceptive processing will advance the search for novel analgesics. We use functional imaging to demonstrate that lateral hypothalamic parvalbumin-positive (LHPV) glutamatergic neurons respond to acute thermal
Justin N Siemian, Miguel A Arenivar, Sarah Sarsfield, Cara B Borja, Lydia J Erbaugh, Andrew L Eagle, Alfred J Robison, Gina Leinninger, Yeka Aponte   +8 more
doaj   +1 more source

Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus [PDF]

, 2020
Aim Since foods with high hedonic value are often consumed in excess of energetic needs, this study was designed to identify the mechanisms that may counter anorexigenic signalling in the presence of hedonic foods in lean animals.
Nils Christian Gassen, Pissioti, Anna, Leidmaa, E., Kallo, I., Imre Kallo, Gassen, N., Este Leidmaa, Patchev, A., Almeida, O., Mayumi Kimura, Gazea, M., Osborne F. X. Almeida, Pissioti, A., Kalló, Imre, Patchev, Alexandre V, Gazea, Mary, Alexandre V. Patchev, Kimura, M., Leidmaa, Este, Liposits, Zsolt, Gassen, Nils Christian, Liposits, Z., Zsolt Liposits, Mary Gazea, Anna Pissioti   +24 more
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source