Results 61 to 70 of about 2,892 (211)

Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism

Journal of Lipid Research, 2007
Nine hypercholesterolemic and hypertriglyceridemic subjects were enrolled in a randomized, placebo-controlled, double-blind, crossover study to test the effect of atorvastatin 20 mg/day and 80 mg/day on the kinetics of apolipoprotein B-100 (apoB-100) in ...
Stefania Lamon-Fava, Margaret R. Diffenderfer, P. Hugh R. Barrett, Aaron Buchsbaum, Nirupa R. Matthan, Alice H. Lichtenstein, Gregory G. Dolnikowski, Katalin Horvath, Bela F. Asztalos, Valeria Zago, Ernst J. Schaefer   +10 more
doaj   +1 more source

Cholesterol-Metabolizing Enzyme Cytochrome P450 46A1 as a Pharmacologic Target for Alzheimer’s Disease [PDF]

, 2017
Cytochrome P450 46A1 (CYP46A1 or cholesterol 24-hydroxylase) controls cholesterol elimination from the brain and plays a role in higher order brain functions.
Arajawa, Hiroyuki, Constans, James, Landreth, Gary, Li, Young, Mast, Natalia, Maxfield, Erin, Pikuleva, Irina A., Saadane, Aicha, Valencia-Olvera, Ana   +8 more
core   +1 more source

Reprogramming SREBP1‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention

International Journal of Cancer, Volume 158, Issue 7, Page 1927-1940, 1 April 2026.
What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan, Elizabeth T. Bartom, Carolina H. Chung, Xingyu Guo, Kyli Berkley, Seyyedmohsen Hosseinibarkooie, Zahra Assadi, Shao Huan Samuel Weng, Raymond Moellering, Oukseub Lee, Ruohui Chen, Wonhwa Cho, Sriram Chandrasekaran, Susan E. Clare, Seema A. Khan   +14 more
wiley   +1 more source

Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study1

Journal of Lipid Research, 2010
Cholesterol synthesis is upregulated and absorption downregulated in insulin resistance and in type 2 dia-betes. We investigated whether alterations in cholesterol metabolism are observed across the glucose tolerance status, from normoglycemia through ...
Helena Gylling, Maarit Hallikainen, Jussi Pihlajamäki, Piia Simonen, Johanna Kuusisto, Markku Laakso, Tatu A. Miettinen   +6 more
doaj   +1 more source

Cholesterol metabolism and weight reduction in subjects with mild obstructive sleep apnoea: a randomised, controlled study [PDF]

, 2013
Peer ...
Gylling, Helena, Hallikainen, Maarit, Kokkarinen, Jouko, Martikainen, Tarja, Randell, Jukka, Seppä, Juha, Tuomilehto, Henri, Vanninen, Esko   +7 more
core   +2 more sources

A Cluster of Three snoRNAs Including Jouvence Required in the Gut Determines Lifespan and Confers Neuroprotection Through Metabolic Parameters

Aging Cell, Volume 25, Issue 4, April 2026.
The disruption of a cluster of three snoRNAs in the epithelium of the gut deregulates the lipid and sterol (including the cholesterol) homeostasis. At the whole‐organism level, this chronic deregulation, all along life, decreases lifespan and leads to neurodegenerative lesions in old flies.
Sara Al Issa, Théo Gauvrit, Patricia Daira, Nathalie Bernoud‐Hubac, Jean‐René Martin   +4 more
wiley   +1 more source

Alterations in cholesterol absorption/synthesis markers characterize Framingham Offspring Study participants with CHD[S]

Journal of Lipid Research, 2009
Data is limited on measures influencing cholesterol homeostasis in subjects at high risk of developing cardiovascular disease (CVD) relative to established risk factors.
Nirupa R. Matthan, Michael Pencina, Jane M. LaRocque, Paul F. Jacques, Ralph B. D'Agostino, Ernst J. Schaefer, Alice H. Lichtenstein   +6 more
doaj   +1 more source

Glycoalkaloid‐Free Starch Potatoes Generated by CRISPR/Cas9‐Mediated Mutations of Genes in the Glycoalkaloid Biosynthesis Pathway Enable More Sustainable Uses of By‐Products From Starch Production

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1344-1358, March 2026.
ABSTRACT Steroidal glycoalkaloids (SGAs) are toxic cholesterol‐derived secondary metabolites present in several Solanaceae species. In potato, tuber SGA levels are for reasons of toxicity of concern in both table and starch cultivars. In the latter, SGAs bind to proteins and fibres in starch production side‐streams and prevent their further uses as ...
Ying Liu, Irene Merino, Mareike Gutensohn, Annika I. Johansson, Kalle Johansson, Mariette Andersson, Per Hofvander, Folke Sitbon   +7 more
wiley   +1 more source

Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption

Journal of Lipid Research, 2002
Heredity of cholesterol absorption and synthesis was studied in siblings of hypercholesterolemic probands with low and high serum cholestanol to cholesterol ratio (assumed to indicate low and high absorption of cholesterol, respectively).
Helena Gylling, Tatu A. Miettinen
doaj   +1 more source

Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis

Scientific Reports, 2022
Lipids play essential roles in the hepatitis C virus (HCV) life cycle and patients with chronic HCV infection display disordered lipid metabolism which resolves following successful anti-viral therapy.
David A. Sheridan, Isaac Thom Shawa, E. Louise Thomas, Daniel J. Felmlee, Simon H. Bridge, Dermot Neely, Jeremy F. Cobbold, Elaine Holmes, Margaret F. Bassendine, Simon D. Taylor-Robinson   +9 more
doaj   +1 more source