Results 61 to 70 of about 1,650 (167)

Cholesterol Deficiency Directs Autophagy‐Dependent Secretion of Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Inhibition of cholesterol biosynthesis within models of rare disease and cancer causes increased release of small extracellular vesicles (sEVs) with distinct biological properties. Mechanistically, cholesterol depletion leads to impaired autophagic flux, redirection of autophagosomes to late endosomes, and subsequently increased sEV secretion ...
Jazmine D. W. Yaeger, Sonali Sengupta, Austin L. Walz, Mayu Morita, Terry K. Morgan, Paola D. Vermeer, Kevin R. Francis   +6 more
wiley   +1 more source

The metabolism of lathosterol by the fruit fly, Drosophila pachea.

, 1971
Uploaded by Plazi for TaxoDros. We do not have abstracts.
openaire   +2 more sources

Sterol Metabolism in Ovariectomized Rats: Potential Roles of Campesterol and 4β‐Hydroxycholesterol in Osteoporosis

Lipids, Volume 61, Issue 1, Page 151-162, January 2026.
ABSTRACT Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. Lipid metabolism disorders may contribute to osteoporosis in postmenopausal women. Phytosterols and oxysterols (OC) are involved in lipid metabolism.
Wenzhao He, Sayuri Eguchi, Sen Wang, Yasutake Tanaka, Masao Sato   +4 more
wiley   +1 more source

Novel ABCG5 and ABCG8 Variants in Sitosterolemia: Insights Into Haemolysis, Calcium Dysregulation and Therapeutic Challenges

Human Mutation, Volume 2026, Issue 1, 2026.
Sitosterolemia is a rare autosomal recessive lipid metabolic disorder caused by mutations in ABCG5 or ABCG8, leading to pathological accumulation of dietary plant sterols. The condition is clinically heterogeneous, presenting with xanthomas, premature atherosclerosis and haematological abnormalities such as stomatocytosis, haemolytic anaemia and ...
Prashant Warang, Rashmi Dongerdiye, Pradnya Dehadrai, Prachi Kamble, Neha Samanpalliwar, Manisha Madkaikar, Chandrakala Shanmukhaiah, Prabhakar S. Kedar, Harleen Khatra   +8 more
wiley   +1 more source

Early and brain region-specific decrease of de novo cholesterol biosynthesis in Huntington's disease: A cross-validation study in Q175 knock-in mice

Neurobiology of Disease, 2017
Cholesterol precursors and cholesterol levels are reduced in brain regions of Huntington's disease (HD) mice. Here we quantified the rate of in vivo de novo cholesterol biosynthesis in the HD brain.
Mahalakshmi Shankaran, Eleonora Di Paolo, Valerio Leoni, Claudio Caccia, Costanza Ferrari Bardile, Hussein Mohammed, Stefano Di Donato, Seung Kwak, Deanna Marchionini, Scott Turner, Elena Cattaneo, Marta Valenza   +11 more
doaj   +1 more source

Systematic Review with Meta‐Analysis of Biofluid Markers for Huntington's Disease

Movement Disorders, Volume 40, Issue 12, Page 2578-2595, December 2025.
Eight Huntington's Disease Biofluid Markers show Meta‐Analytic Significance Across HD‐ISS Stages. Meta‐analyses were conducted for two types of biomarkers: Different from demographically‐matched healthy controls and *Showing change over time. Abstract Primary therapeutic objectives for Huntington's disease (HD) necessitate continued therapy for a long ...
Jane S. Paulsen, Natalie A. Bovin, Jordan D. Clemsen, Alexander Weiss, Abigail M. Key, Monica L. Janz, Alex Pinto, Deven K. Burks, Henrik Zetterberg, Kathleen M. Shannon   +9 more
wiley   +1 more source

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Journal of Lipid Research, 2004
24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously crossing the blood-brain barrier to reach the circulation. There may be an opposite flux of 27-hydroxycholesterol, which is formed to a lower extent in the
Maura Heverin, Nenad Bogdanovic, Dieter Lütjohann, Thomas Bayer, Irina Pikuleva, Lionel Bretillon, Ulf Diczfalusy, Bengt Winblad, Ingemar Björkhem   +8 more
doaj   +1 more source

Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma

Cells, 2020
Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Mitotane, the standard treatment for ACC, impairs adrenocortical steroid biosynthesis and cholesterol metabolism.
Antonina Germano, Daniela Rossin, Valerio Leoni, Noemi Iaia, Laura Saba, Vittoria Basile, Soraya Puglisi, Claudio Caccia, Giuseppe Poli, Fiorella Biasi, Massimo Terzolo   +10 more
doaj   +1 more source

Miglustat in Alzheimer's Disease Associated With Heterozygous NPC1 Mutation: Exploratory Case Series and Preliminary Findings

European Journal of Neurology, Volume 32, Issue 11, November 2025.
Three AD patients sharing the same heterozygous NPC1 mutation were orally treated with miglustat for 12 months and underwent monthly clinical and neuropsychological evaluations, brain amyloid‐PET imaging, and biochemical analyses on plasma and CSF. All three patients achieved clinical stability, showed a sustained reduction in serum oxysterol levels ...
Diego Lopergolo, Daniele Gasparini, Silvia Bianchi, Barbara Pucci, Domenico Tripodi, Valerio Leoni, Andrea Chincarini, Stelvio Sestini, Henrik Zetterberg, Nicola De Stefano, Andrea Mignarri   +10 more
wiley   +1 more source

Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia.

Journal of Lipid Research, 1991
Patients with heterozygous familial hypercholesterolemia (n = 12) were treated either with pravastatin, a specific inhibitor of HMG-CoA reductase, or cholestyramine, followed by a period of combined treatment with both drugs.
PG Elmberger, A Kalén, E Lund, E Reihnér, M Eriksson, L Berglund, B Angelin, G Dallner   +7 more
doaj   +1 more source