Results 51 to 60 of about 2,892 (211)

Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents [PDF]

, 2011
Background During the past decade, proprotein convertase subtilisin kexin type 9 (PCSK9) has been identified as a key regulator of serum LDL-cholesterol (LDL-C) levels.
Robert J Konrad, Jason S Troutt, Guoqing Cao   +2 more
core   +2 more sources

Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg, Jesus M. Banales, Gideon Hirschfield, Palak Trivedi, Edward E. Cable, Charles A. McWherter, Andrew N. Billin, Daria B. Crittenden, Grant Budas   +8 more
wiley   +1 more source

Association between cholesterol synthesis/absorption markers and effects of cholesterol lowering by atorvastatin among patients with high risk of coronary heart disease[S]

Journal of Lipid Research, 2013
No indices are currently available to facilitate clinicians to identify patients who need either statin monotherapy or statin-ezetimibe combined treatment.
Yue Qi, Jing Liu, Changsheng Ma, Wei Wang, Xiaohui Liu, Miao Wang, Qiang Lv, Jiayi Sun, Jun Liu, Yan Li, Dong Zhao   +10 more
doaj   +1 more source

Mutations in the _SC4MOL_ gene encoding a novel methyl sterol oxidase cause autosomal recessive psoriasisiform dermatitis, microcephaly and developmental delay [PDF]

, 2008
Disorders of cholesterol biosynthesis have clinical manifestations involving skeleton, eyes, neurologic development, and skin. We describe a patient with congenital cataracts, developmental delay, microcephaly, and low serum cholesterol who developed ...
Abbe Vallejo, Gerard Vockley, Jacqueline Hoover, Jushua Michel, Laura Ferris, Lisa Kratz, Miao He, Michael Gibson, Richard Kelley   +8 more
core   +1 more source

High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body

Journal of Internal Medicine, Volume 299, Issue 5, Page 628-638, May 2026.
Abstract Background Elevated low‐density lipoprotein (LDL) cholesterol causes atherosclerotic cardiovascular diseases. Variables of whole‐body cholesterol metabolism, for example, high cholesterol absorption efficiency, might also be atherogenic, whereas the role of bile acids is controversial.
Piia Simonen, Ingmar Wester, Jyri Lommi, Juha Sinisalo, Helena Gylling   +4 more
wiley   +1 more source

The relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease1s⃞

Journal of Lipid Research, 2009
Changes in the balance of cholesterol absorption and synthesis and moderately elevated plasma plant sterols have been suggested to be atherogenic. Measuring cholestanol, lathosterol, campesterol, and sitosterol, we investigated the relationships of ...
Guenther Silbernagel, Guenter Fauler, Wilfried Renner, Eva M. Landl, Michael M. Hoffmann, Bernhard R. Winkelmann, Bernhard O. Boehm, Winfried März   +7 more
doaj   +1 more source

Functional genomics reveals increases in cholesterol biosynthetic genes and highly unsaturated fatty acid biosynthesis after dietary substitution of fish oil with vegetable oils in Atlantic salmon () [PDF]

, 2008
Background There is an increasing drive to replace fish oil (FO) in finfish aquaculture diets with vegetable oils (VO), driven by the short supply of FO derived from wild fish stocks.
Michael J Leaver, Laure AN Villeneuve, Alex Obach, Linda Jensen, James E Bron, Douglas R Tocher, John B Taggart   +6 more
core   +3 more sources

Mapping molluscan endocrinology: a systematic and critical appraisal

Biological Reviews, Volume 101, Issue 2, Page 970-1002, April 2026.
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis, Thomas H. Miller, Olwenn V. Martin, Alice Baynes   +3 more
wiley   +1 more source

The lipid-lowering effect of ezetimibe in pure vegetarians

Journal of Lipid Research, 2006
Results of previous studies have shown that ezetimibe (10 mg/day) reduces LDL cholesterol in patients with mild hypercholesterolemia on a normal-cholesterol diet (dietary intake of 200–500 mg/day) by 16–22%.
Jacob J. Clarenbach, Michael Reber, Dieter Lütjohann, Klaus von Bergmann, Thomas Sudhop   +4 more
doaj   +1 more source

Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols [PDF]

, 2019
Chorioamnionitis, clinically most frequently associated with Ureaplasma, is linked to intestinal inflammation and subsequent gut injury. No treatment is available to prevent chorioamnionitis-driven adverse intestinal outcomes. Evidence is increasing that
Alan H. Jobe, Berta Cillero Pastor, Boris W. Kramer, Charlotte van Gorp, Frédéric Dewez, Ilse H. de Lange, Jogchum Plat, Lilian Kessels, Luc J. Zimmermann, Matthew S. Payne, Matthew W. Kemp, Michael L. Beeton, Nico Kloosterboer, Owen B. Spiller, Ron M. A. Heeren, Sarah J. Stock, Tim G. A. M. Wolfs, Wim G. van Gemert, Woollett   +18 more
core   +4 more sources