Results 71 to 80 of about 1,616 (166)
Advanced Science, Volume 12, Issue 38, October 13, 2025.The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang +15 more
wiley +1 more source
Journal of Lipid Research, 1996 Mechanisms of hyperlipidemia were studied by measurement of serum lipid concentrations and the ratios of cholesterol precursors (squalene, delta 8-cholestenol, desmosterol, and lathosterol), plant sterols (campesterol and sitosterol), and cholestanol (a ...
K Nikkilä +3 more
doaj +1 more source
The relationships of markers of cholesterol homeostasis with carotid intima-media thickness.
PLoS ONE, 2010 BackgroundThe relationship of cholesterol homeostasis and carotid intima-media thickness (cIMT) is unknown. To address this, we assessed markers of cholesterol homeostasis (serum plant sterols and cholesterol precursor concentrations as surrogate ...
Oliver Weingärtner +12 more
doaj +1 more source
α-Tocopherol modulates the low density lipoprotein receptor of human HepG2 cells
Nutrition Journal, 2003 The aim of this study was to determine the effects of vitamin E (α-tocopherol) on the low density lipoprotein (LDL) receptor, a cell surface protein which plays an important role in controlling blood cholesterol. Human HepG2 hepatoma cells were incubated
Bottema Cynthia DK +3 more
doaj +1 more source
Journal of Lipid Research, 1966 Methods were developed for the separation and determination of the various 27-carbon sterols of intestinal mucosa by means of thin-layer chromatography.
Robert K. Ockner, Leonard Laster
doaj +1 more source
Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain
Journal of Lipid Research, 2002 Cholesterol is implicated to play a role in Alzheimer disease pathology. Therefore, the concentrations of cholesterol, its precursors, and its degradation products in brain homogenates of aging wild-type and β-amyloid precursor protein transgenic mice ...
Dieter Lütjohann +8 more
doaj +1 more source
Accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves
Journal of Lipid Research, 2008 The pathogenesis of aortic valve stenosis (AS) is characterized by the accumulation of LDL-derived cholesterol in the diseased valves. Since LDL particles also contain plant sterols, we investigated whether plant sterols accumulate in aortic valve ...
Satu Helske +8 more
doaj +1 more source
Journal of Lipid Research, 2010 Proprotein convertase, subtilisin/kexin type 9 (PCSK9), a key regulator of plasma LDL-cholesterol (LDL-c) and cardiovascular risk, is produced in liver and secreted into plasma where it binds hepatic LDL receptors (LDLR), leading to their degradation ...
Jeffrey D. Browning, Jay D. Horton
doaj +1 more source
Phytosterolemia on the island of Kosrae
Journal of Lipid Research, 2004 Screening of 932 adults on the Pacific island of Kosrae for plasma plant sterol levels disclosed three subjects, two of them asymptomatic, with phytosterolemia. Sequencing the ATP binding cassette subfamily G member 8 (ABCG8) gene revealed a novel exon 2
Ephraim Sehayek +10 more
doaj +1 more source
Separations, 2018 Oxysterols are metabolites produced in the first step of cholesterol metabolism, which is related to neurodegenerative disorder. They can be detected by testing blood, plasma, serum, or cerebrospinal fluid.
Lucia Valverde-Som +7 more
doaj +1 more source