Results 71 to 80 of about 2,892 (211)

The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts [PDF]

, 2018
K
Balogh, István, Kim, Hye-Young H., Koczok, Katalin, Korade, Zeljka, Liu, Wei, Mirnics, Károly, Porter, Ned A., Tallman, Keri A., Xu, Libin   +8 more
core   +1 more source

P0676CHOLESTEROL ABSORPTION JUGDED BY CAMPESTEROL / LATHOSTEROL RATIO AND OUTCOMES IN CHRONIC KIDNEY DISEASE

Nephrology Dialysis Transplantation, 2020
Abstract Background and Aims In dialysis patients, cholesterol-lowering therapy with statins is less effective than in other high-risk patients. This may partly be explained by a shift from cholesterol synthesis, which is inhibited by statin treatment, towards cholesterol absorption, which is ...
Weingärtner Oliver, Lütjohann Dieter, Michael Böhm, Wagenpfeil Stefan, Danilo Fliser, Kyrill S Rogacev, Schulze Christian, Gunnar Henrik Heine, Insa Elena Emrich   +8 more
openaire   +1 more source

NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression

Advanced Science, Volume 13, Issue 7, 3 February 2026.
NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu, Jixin Ma, Minwei Zhou, Xiaodong Gu, Yiming Zhou, Zhenyang Li, Tianyu Zhang, Wei Gong, Chuanxin Huang, Jianbin Xiang   +9 more
wiley   +1 more source

Successful treatment of lathosterolosis: A rare defect in cholesterol biosynthesis—A case report and review of literature

JIMD Reports, 2020
Lathosterolosis is a rare autosomal recessive disorder of cholesterol biosynthesis. It is caused by defects in the SC5D (sterol C5‐desaturase) gene which encodes for the 3‐beta‐hydroxysteroid‐delta‐5‐desaturase (also called sterol‐C5‐desaturase or ...
Joy Yaplito‐Lee, Gautham Pai, Winita Hardikar, Kai M. Hong, James Pitt, Justine Marum, David J. Amor   +6 more
doaj   +1 more source

Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice [PDF]

, 2015
Brain cholesterol biosynthesis and cholesterol levels are reduced in mouse models of Huntington's disease (HD), suggesting that locally synthesized, newly formed cholesterol is less available to neurons.
Alessandro Vercelli, Barbara Ruozi, Carlos Cepeda, Claudio Caccia, Costanza Ferrari Bardile, Daniela Belletti, Elena Cattaneo, Eleonora Di Paolo, Elisa Brilli, Flavio Forni, Giovanni Tosi, HDCRG, Jane Y Chen, Maria A Vandelli, Marina M Boido, Marta Valenza, Marullo M, Michael S Levine, Paxinos G, Sethi A, Stefano Di Donato, Trager U, Valerio Leoni   +22 more
core   +4 more sources

Dual‐Pathway Defense: Ultramicro‐Pulverised Powder of Polygonum chinense L. and Atractylodes rhizome (PAUP) Rescues Broilers From E. coli‐Triggered Liver Injury Through Modulation of Oxidative Stress and Inflammation

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Reduced Antibiotic residues and resistance concerns: Offers a potential natural alternative to antibiotics for combating E. coli infections in poultry. Provided safer poultry food products: By enhancing liver function, restoring weight gain, and improving feed efficiency, PAUP supports the production of healthier chickens, ultimately contributing to ...
Jia‐Ci Cai, Yan‐Na Guo, Shao‐Shan Liang, Yan Liu, Fu‐Qiang Huang, Qi‐Peng Lv, Lan‐Yi Zhang, Yi Qin, Xiao‐Jing Chen, Yu‐Xin Liang, Yong‐Ming He, Lu‐Ping Tang   +11 more
wiley   +1 more source

Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers*[S]

Journal of Lipid Research, 2009
We measured plasma markers of cholesterol synthesis (lathosterol) and absorption (campesterol, sitosterol, and cholestanol) in order to compare the effects of maximal doses of rosuvastatin with atorvastatin and investigate the basis for the significant ...
Thomas M. van Himbergen, Nirupa R. Matthan, Nancy A. Resteghini, Seiko Otokozawa, Masumi Ai, Evan A. Stein, Peter H. Jones, Ernst J. Schaefer   +7 more
doaj   +1 more source

Studies on PCSK9 in the regulation of cholesterol metabolism [PDF]

, 2011
Elevated levels of plasma cholesterol, mainly in low density lipoproteins (LDL), are a major risk factor for coronary heart disease. The level of plasma LDL cholesterol (LDL-C) is largely dependent on the number of hepatic LDL receptors (LDLRs ...
Persson, Lena
core   +1 more source

Cholesterol Deficiency Directs Autophagy‐Dependent Secretion of Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Inhibition of cholesterol biosynthesis within models of rare disease and cancer causes increased release of small extracellular vesicles (sEVs) with distinct biological properties. Mechanistically, cholesterol depletion leads to impaired autophagic flux, redirection of autophagosomes to late endosomes, and subsequently increased sEV secretion ...
Jazmine D. W. Yaeger, Sonali Sengupta, Austin L. Walz, Mayu Morita, Terry K. Morgan, Paola D. Vermeer, Kevin R. Francis   +6 more
wiley   +1 more source

The associations of cholesterol metabolism and plasma plant sterols with all-cause and cardiovascular mortality[S]

Journal of Lipid Research, 2010
Moderately elevated levels of plasma plant sterols have been suspected to be causally involved in atherosclerosis. The aim of this study was to investigate whether plant sterols and other markers of sterol metabolism predicted all-cause and ...
Guenther Silbernagel, Guenter Fauler, Michael M. Hoffmann, Dieter Lütjohann, Bernhard R. Winkelmann, Bernhard O. Boehm, Winfried März   +6 more
doaj   +1 more source