Results 91 to 100 of about 2,892 (211)
European Journal of Neurology, Volume 32, Issue 11, November 2025.Three AD patients sharing the same heterozygous NPC1 mutation were orally treated with miglustat for 12 months and underwent monthly clinical and neuropsychological evaluations, brain amyloid‐PET imaging, and biochemical analyses on plasma and CSF. All three patients achieved clinical stability, showed a sustained reduction in serum oxysterol levels ...
Diego Lopergolo +10 more
wiley +1 more source
Neurobiology of Disease, 2017 Cholesterol precursors and cholesterol levels are reduced in brain regions of Huntington's disease (HD) mice. Here we quantified the rate of in vivo de novo cholesterol biosynthesis in the HD brain.
Mahalakshmi Shankaran +11 more
doaj +1 more source
Brain cholesterol in normal and pathological aging [PDF]
, 2011 Aberrations in cerebral cholesterol homeostasis can lead to severe neurological diseases. Recent findings strengthen the link between brain cholesterol metabolism and factors involved in synaptic plasticity, a process essential for learning and memory ...
Lütjohann, D. (Dieter) +2 more
core +5 more sources
Advanced Science, Volume 12, Issue 38, October 13, 2025.The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang +15 more
wiley +1 more source
Journal of Lipid Research, 2004 24S-hydroxycholesterol is a side-chain oxidized oxysterol formed in the brain that is continuously crossing the blood-brain barrier to reach the circulation. There may be an opposite flux of 27-hydroxycholesterol, which is formed to a lower extent in the
Maura Heverin +8 more
doaj +1 more source
Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma
Cells, 2020 Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Mitotane, the standard treatment for ACC, impairs adrenocortical steroid biosynthesis and cholesterol metabolism.
Antonina Germano +10 more
doaj +1 more source
The effect of the apolipoprotein E phenotype on plasma lipids is not influenced by environmental variability: results of a Dutch twin study [PDF]
, 1993 We tested the influence of the apolipoprotein E (apoE) polymorphism on the intrapair differences in the levels of plasma cholesterol, plasma triglycerides, low density lipoprotein-cholesterol, apoB and apoE in monozygotic (MZ) twins, and estimated ...
Boomsma, D.I. +6 more
core +2 more sources
Journal of Lipid Research, 1991 Patients with heterozygous familial hypercholesterolemia (n = 12) were treated either with pravastatin, a specific inhibitor of HMG-CoA reductase, or cholestyramine, followed by a period of combined treatment with both drugs.
PG Elmberger +7 more
doaj +1 more source
Randomized controlled trial of the effect of phytosterols-enriched low-fat milk on lipid profile in Chinese [PDF]
, 2017 published_or_final_versio
CHENG, KF +7 more
core +1 more source
Journal of Veterinary Internal Medicine, Volume 39, Issue 5, September/October 2025.ABSTRACT Background In previous studies, only a subset of dogs with chronic enteropathy (CE) had an increased dysbiosis index (DI) or altered fecal metabolites or both, suggesting differences in underlying intestinal pathophysiology between these subsets.
Chih‐Chun Chen +13 more
wiley +1 more source