Results 121 to 130 of about 21,610 (241)

Transaminase and Norcoclaurine Synthase One‐Pot Cascades Towards (1S)‐Tetrahydroisoquinolines

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
A TAm‐NCS cascade towards THIQs has been established, starting from amines with the in situ production of aldehydes. The cascade was used with a variety of nonfunctionalized and functionalized amines, and reaction conditions modified to enhance formation of the desired cross‐products.
Jianxiong Zhao, Yeke Ni, Yu Wang, John M. Ward, Jack W. E. Jeffries, Helen C. Hailes   +5 more
wiley   +1 more source

Rh‐Catalyzed [2 + 2 + 2] Cycloaddition of Linked Bis(Diynes) Ar‐C≡C‐C≡C‐(CH2)3‐C≡C‐C≡C‐Ar With Quinones: Synthesis and Photophysical Properties of Bis(Arylethynyl)‐Naphthoquinones and Anthraquinones

Chemistry – A European Journal, Volume 32, Issue 11, 16 March 2026.
We report the synthesis bis(arylethynyl)naphtho‐ and anthraquinones via Rh(I)‐catalyzed [2 + 2 + 2] cycloaddition reactions. The substrate scope of both quinones and linked bis‐diynes was explored. Microwave irradiation remarkably enhanced yields.
Luana A. Machado, Jianhua Han, Fábio G. Delolo, Joyce C. Oliveira, Breno U. Abreu, Hállen D. R. Calado, Joannes Krebs, Leibo Tan, Qing Ye, Tobias Groß, Christoph Lambert, Camille Latouche, Abdou Boucekkine, Jean‐François Halet, Holger Braunschweig, Todd B. Marder, Eufrânio N. da Silva Júnior   +16 more
wiley   +1 more source

Discrimination of Bipolar Disorder and Schizophrenia Patients Based on LC-HRMS Lipidomics. [PDF]

Metabolites
Janković MR, Avramović N, Miladinović Z, Jadranin MB, Takić M, Krstić G, Gavrilović A, Miljević Č, Pantović M, Andrić Z, Radević S, Savić D, Lekić S, Tešević V, Mandić B.   +14 more
europepmc   +1 more source

Identification of Natural Isonitriles Through Ligation to an Azomethine Imine Probe

Chemistry – A European Journal, Volume 32, Issue 11, 16 March 2026.
The azomethine imine (AMI)–isonitrile (NC) ligation allowed for the chemoselective detection of natural isonitriles in bacteria and fungi. The reactivity‐based screening establishes a new stereogenic center, thereby allowing for facile distinction between chiral and achiral isonitriles. The work also unraveled a unique reactivity of isonitriles bearing
Maurice P. Biedermann, Alexander Brachmann, Shurui Mai, Athanasios Markos, Markus Künzler, Jörn Piel, Helma Wennemers   +6 more
wiley   +1 more source

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica, Carla Barbaraci, M. Carmen Ruiz‐Cantero, Arianna Scarlatti, Alessandro Coco, Giorgia Giordano, Alfonsina La Mantia, Orazio Prezzavento, Antonio Di Stefano, Ivana Cacciatore, Giacomo Siano, Antonino Cattaneo, Lorella Pasquinucci, Enrique J. Cobos, Cristina Di Primio, Emanuele Amata, Agostino Marrazzo   +16 more
wiley   +1 more source

Untargeted LC-HRMS-Based Metabolomic and Antibacterial Potential of Sargassum duplicatum Against Multidrug-Resistant Bacteria. [PDF]

Medicina (Kaunas)
Susanto F, Riyanti, Syakuri H, Nursid M, Schäberle TF, Mettal U, Choi JS, Meinita MDN.   +7 more
europepmc   +1 more source

AZA Toxin Profiles by LC-HRMS in Shellfish from Šibenik Bay: AZA-2 Predominant Analog. [PDF]

Molecules
Bulić A, Pezelj I, Ujević I, Bogdanović T, Orhanović S.   +4 more
europepmc   +1 more source

Overcoming challenges in untargeted LC-HRMS-based metabolomics approaches

Die Flüssigkeitschromatografie – Hochauflösungs-Massenspektrometrie (LC-HRMS) wird in Metabolomstudien für den ungerichteten Nachweis einer möglichst großen Metabolitzahl in biologischen Proben eingesetzt. Nachweis, Annotierung und Identifikation der Metabolite sowie deren Quantifizierung in biologischen Proben stellen nach wie vor eine große ...
openaire  

Metabolite Profiling and Anticancer Evaluation of Iraqi Haloxylon articulatum Halophyte via LC-HRMS/MS, Molecular Docking, and ADMET Analysis. [PDF]

Chem Biodivers
Abidi J, Hassena AB, Hmida RB, Kulinowski Ł, Aytar EC, Al-Rashidi RR, Bouaziz M.   +6 more
europepmc   +1 more source

Guest‐Induced Activation of Multicolor Photoluminescence in Naphthalene Bisimide Liquid Crystals

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
Supramolecular host–guest design in naphthalene bisimide liquid crystals activates charge‐transfer emission and enables continuous tuning of color (511–685 nm) and lifetime, spanning prompt fluorescence, TADF, and RTP. Electron‐rich guests and Pt(II) complexes modulate emissive states, while co‐assembled NBI complexes create an energy‐transfer cascade ...
Johannes Nowarra, Swadhin Garain, Matthias Stolte, Frank Würthner   +3 more
wiley   +1 more source