Results 201 to 210 of about 21,610 (241)

4‐(5‐Chloro‐3‐(3,4,5‐trimethoxybenzoyl)‐1H‐indol‐1‐yl)benzenesulfonamide: A Novel Polypharmacology Agent to Target Carbonic Anhydrase IX and XII With Improved Selectivity, Wnt/β‐Catenin Signaling Pathway, and P‐Glycoprotein

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Polypharmacology is expected to produce higher therapeutic efficacy and lower cytotoxic and side effects. Compound 15 exhibited strong inhibition of the human carbonic anhydrase isoforms IX and XII and selectivity toward the adverse isoforms I and II.
Michela Puxeddu, Rosa Bordone, Claudia Colla, Gabriele Rotili, Antonio Coluccia, Pietro Sciò, Petra Cuřínová, Alessio Nocentini, Claudiu T. Supuran, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Kopecka, Chiara Riganti, Lucia Jimenez, Wolfgang Link, Chiara Bigogno, Giulio Dondio, Martina Barba, Gianluca Canettieri, Romano Silvestri, Giuseppe La Regina   +21 more
wiley   +1 more source

Detection of the GH analog somatrogon in sports drug testing: Immunological approaches and LC-HRMS/MS. [PDF]

Drug Test Anal
Walpurgis K, Thomas A, Sato M, Okano M, Geyer H, Thevis M.   +5 more
europepmc   +1 more source

An Imidazo[2,1‐b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor α‐Hemolysin by Blocking the Pullout of Its Stem Domain

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
A high‐throughput cellular screen based on Ca2+ influx in U937 monocytic cells identified thiadiazoles as small‐molecule inhibitors of α‐hemolysin, a key virulence factor of Staphylococcus aureus. The thiadiazole 1 prevents pore formation by a dual mechanism that prevents stem loop unfolding as well as membrane attachment.
Vadim S. Korotkov, Peer Lukat, Raffaella Di Lucrezia, Aditya Shekhar, Carsten Degenhart, Randi Diestel, Ursula Bilitewski, Klaus Dinkel, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Unlocking the Complexity of Antibody-Drug Conjugates: A Cutting-Edge LC-HRMS Approach to Refine Drug-to-Antibody Ratio Measurements with Highly Reactive Payloads. [PDF]

Int J Mol Sci
Di Ianni A, Cowan KJ, Riccardi Sirtori F, Barbero L.   +3 more
europepmc   +1 more source

Toward a Cannabis Terroir: Untargeted Metabolomic Profiling of Authentic Samples Using Gas Chromatography-High-Resolution Mass Spectrometry (GC-HRMS) and Liquid Chromatography-High-Resolution Tandem Mass Spectrometry (LC-HRMS/MS). [PDF]

Drug Test Anal
Poetzsch SN, Poetzsch M, Kraemer T, Steuer AE.   +3 more
europepmc   +1 more source

Critical review on in silico methods for structural annotation of chemicals detected with LC/HRMS non-targeted screening. [PDF]

Anal Bioanal Chem
Hupatz H, Rahu I, Wang WC, Peets P, Palm EH, Kruve A.   +5 more
europepmc   +1 more source

Application of a molecular networking approach using LC-HRMS combined with the MetWork webserver for clinical and forensic toxicology. [PDF]

Heliyon
Magny R, Beauxis Y, Genta-Jouve G, Bourgogne E.   +3 more
europepmc   +1 more source

Enhanced Surveillance of >1100 Pesticides and Natural Toxins in Food: Harnessing the Capabilities of LC-HRMS for Reliable Identification and Quantification. [PDF]

Foods
Bessaire T, Savoy MC, Ernest M, Christinat N, Badoud F, Desmarchelier A, Carrères B, Chan WC, Wang X, Delatour T.   +9 more
europepmc   +1 more source

Bridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC-HRMS in a Single Run for Sensitive Exposomics. [PDF]

Anal Chem
Verri Hernandes V, Warth B.
europepmc   +1 more source

Do experimental projection methods outcompete retention time prediction models in non-target screening? A case study on LC/HRMS interlaboratory comparison data.

Analyst
Malm L, Kruve A.
europepmc   +1 more source