Results 211 to 220 of about 100,610 (290)

ROC‐325 Attenuates Hypoxia‐Induced Pulmonary Hypertension Through Dual Inhibition of Autophagy and Hypoxia‐Inducible Factor 2α Signaling

open access: yesMedComm – Future Medicine, Volume 5, Issue 1, March 2026.
In hypoxia‐induced pulmonary hypertension, endothelial HIF‐2α accumulation and autophagic activation drive vascular remodeling. We demonstrate that the novel lysosomal inhibitor ROC‐325 simultaneously attenuates this pathogenic autophagy and promotes HIF‐2α degradation.
Changlei Bao   +18 more
wiley   +1 more source

Clays for Low-Carbon Cements: Overview, Progress, and Challenges. [PDF]

open access: yesGlob Chall
Koufany I   +4 more
europepmc   +1 more source

Secretory autophagy and epithelial‐to‐mesenchymal transition in cadaveric AMD samples: Novel pathways in disease progression

open access: yesActa Ophthalmologica, Volume 104, Issue 2, Page 239-251, March 2026.
Abstract Purpose To examine the presence of secretory autophagy and epithelial–mesenchymal transition (EMT) in the macular retinal pigment epithelium (RPE) of human cadaver eyes with different forms of age‐related macular degeneration (AMD). Methods Human cadaver macula samples representing dry and wet AMD, as well as age‐matched controls, were ...
Iswariyaraja Sridevi Gurubaran   +3 more
wiley   +1 more source

NDR2 regulates non-small cell lung cancer cell migration under starvation by supporting autophagosome biogenesis through LC3 and ATG9A regulation. [PDF]

open access: yesCell Death Discov
Biojout T   +10 more
europepmc   +1 more source

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1622-1637, March 2026.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani   +1 more
wiley   +1 more source

Sex‐Specific doublesex Regulation Targeting the Color‐Patterning Gene h Underlies the Evolution of Wing Sexual Dimorphism in the Harlequin Ladybug Harmonia axyridis

open access: yesEvolution &Development, Volume 28, Issue 1, March 2026.
doublesex regulates sexual dimorphism in elytral color patterns of Harmonia axyridis by downregulating the color patterning gene h in males. This regulatory link diverged in derived color morphs, coinciding with the loss of sex‐specific elytral color patterns.
Soichi Yeki   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy