Results 231 to 240 of about 125,401 (357)

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Functional status and health-related quality of life following Young and Burgess classified pelvic ring injuries. [PDF]

PLoS One
Therrien CC, Uil M, Ten Duis K, Banierink H, Meesters AML, Trouwborst NM, Hamminga AJ, de Vries JPM, IJpma FFA, Reininga IHF.   +9 more
europepmc   +1 more source

Distinct Roles of Myeloid‐ and Hepatocyte‐PLA2G6 Deletion in Mice With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Polymorphisms of group VIA calcium‐independent phospholipase A2 (iPLA2β or PLA2G6) are associated with Type‐2 diabetes, blood lipids and inflammation. Global deficiency in iPLA2β‐null mice elicited protection against hepatic steatosis but not hepatic inflammation after high‐fat diet (HFD) feeding.
Gang Li, Simone Staffer, Sabine Tuma‐Kellner, Uta Merle, Walee Chamulitrat   +4 more
wiley   +1 more source

Discovery of Autophagy Modulators that Increase I1061T NPC1 Expression and Promote Cholesterol Efflux in Niemann-Pick Type C Patient-Derived Fibroblasts. [PDF]

ACS Chem Biol
Salkovski M, Arrieche Suarez A, Gao Q, Hippman RS, Petros ZA, Korkmaz-Vaisys MA, Gerlach EM, Alvarado-Cartagena YM, Nguyen TTA, Pavlinov I, Ilnytska O, Storch J, Cologna SM, Aldrich LN.   +13 more
europepmc   +1 more source

Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice [PDF]

, 2017
Aagaard, Barrows, Bayer, Bin Cao, Cadwell, Cao, Cao, Cao-Lormeau, Cemma, Chibueze, Chiramel, Delorme-Axford, Delvecchio, El Costa, Elfiky, Eyer, Farias, Hamel, Indira U. Mysorekar, Jurado, Kaplan, Khan, Klionsky, Lamont, Lennemann, Levine, Liang, Lindsay A. Parnell, Martín-Acebes, Mateo, Michael S. Diamond, Miner, Mysorekar, Pirooz, Quicke, Rosenfeldt, Rossant, Sacramento, Savarino, Sharma, Shoji-Kawata, Signorelli, Tabata, Tricou, Vandergaast, Vermillion, Wenzel, Xu, Yockey, Zmurko   +49 more
core   +2 more sources

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Gandouling protects against hepatic fibrosis in Wilson disease through the lncRNA-SNHG7/miR-29b/DNMT3A pathway. [PDF]

3 Biotech
Wang H, Sun L, Yin X, Hua D, Xuan Q, Wang J, Dong W, Yang W.   +7 more
europepmc   +1 more source

Molecular Mechanism of LC3 Lipidation and the Role of LC3 in Autophagosome Biogenesis

Molecular Mechanism of LC3 Lipidation and the Role of LC3 in Autophagosome Biogenesis
総研大甲第1165号
openaire  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, Volume 16, Issue 5, Page 870-884, May 2026.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3. [PDF]

Aging Cell
Wu ZL, Ran R, Xie QQ, Zhang C, Chen YJ, Cheng P, Wang KP, Zhang HH.   +7 more
europepmc   +1 more source