Results 211 to 220 of about 80,188 (258)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

CircHECTD1 Promotes Cholangiocarcinoma Progression Through Interaction With SFPQ to Induce Autophagy

Cancer Science, EarlyView.
CircHECTD1 directly interacts with SFPQ to upregulate ATG12 expression, thereby activating autophagy and promoting cholangiocarcinoma progression. This study uncovers a noncanonical circRNA–RNA‐binding protein regulatory mechanism and provides a potential therapeutic target for cholangiocarcinoma.
Shouwen Zhao, Shanshan Jiang, Xutong Wang, Kai Cui, Zhilei Cao, Le Zhang, Zhiqiang Wei, Yuping Ma, Han Hao, Kunpeng Zhang, Jiamin Zhang, Tianyu Dong   +11 more
wiley   +1 more source

Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates. [PDF]

Angew Chem Int Ed Engl
Cho YT, Jao CY, Xia Z, White-Mathieu BM, Salic A, Baskin JM.   +5 more
europepmc   +1 more source

Localised Autophagy Inhibition by Nanodiamonds Potentiates Arsenic Therapy With Favourable Safety Profile in Solid Tumours

Cell Proliferation, EarlyView.
This study presents an NDs‐mediated localised combination strategy that integrates autophagy inhibition with low‐dose ATO sensitization, enabling effective tumour suppression while enhancing safety. NDs‐mediated autophagy blockade enhances ATO efficacy while minimising systemic toxicity, highlighting a promising approach for solid tumour treatment ...
Yiliu Wang, Zhifen Cui, Jichao Zhang, Shitai Zhu, Linjie Guo, Qisheng Wang, Ying Zhu, Shihua Luo, Huating Kong   +8 more
wiley   +1 more source

Outside-In Signaling as a Detonator-like Stimulus of Integrin Activation by Promoting Both Affinity and Avidity. [PDF]

Biomolecules
Kondo N, Kinashi T.
europepmc   +1 more source

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression

Cell Proliferation, EarlyView.
PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia, Man Li, Yanyu Chen, Jialin Chen, Yuting Cui, Xi‐Long Zheng, Jing Yang, Bingzhao Li, Xiaofeng Ma, Miao Liu, Gang Fan, Juan Peng, Xiaoyan Dai, Zhihan Tang   +13 more
wiley   +1 more source

1,8-Cineole improves hepatic fibrosis by inhibiting HIF-1α/BNIP3/PINK1/Parkin-dependent mitophagy signaling and inducing apoptosis in activated hepatic stellate cells. [PDF]

Front Pharmacol
Qin L, Tan J, He C, He M, Zhang J.
europepmc   +1 more source

Itgb1‐Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress‐Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1‐Parkin‐Dependent Mitophagy

Cell Proliferation, EarlyView.
Excessive mechanical stress induces nucleus pulposus cell pyroptosis and intervertebral disc degeneration. Itgb1 inhibits MNAT1‐mediated ubiquitination and degradation of Vimentin. Vimentin alleviates excessive mechanical stress‐induced nucleus pulposus cell pyroptosis and intervertebral disc degeneration through PINK1‐Parkin‐dependent mitophagy ...
Xuening Liu, Fengguang Yang, Yanni Duan, Hefang Xiao, Zhenyu Cao, Zhaoheng Wang, Haijun Zhang, Xuewen Kang   +7 more
wiley   +1 more source

Polyphyllin II attenuates renal fibrosis in diabetic kidney disease partly through regulation of autophagy and PI3K/AKT/mTOR signaling. [PDF]

Front Pharmacol
Sun X, Qin X, Bi H.
europepmc   +1 more source