Results 11 to 20 of about 12,546 (159)
Mathematical Model Predicting the Kinetics of Intracellular LCMV Replication
Mathematics, 2023 The lymphocytic choriomeningitis virus (LCMV) is a non-cytopathic virus broadly used in fundamental immunology as a mouse model for acute and chronic virus infections.
Julia Sergeeva +5 more
doaj +3 more sources
Complexities of Type I Interferon Biology: Lessons from LCMV [PDF]
Viruses, 2019 Over the past decades, infection of mice with lymphocytic choriomeningitis virus (LCMV) has provided an invaluable insight into our understanding of immune responses to viruses.
Tamara Suprunenko, Markus J. Hofer
doaj +3 more sources
A Novel Murine Model of Hemophagocytic Lymphohistiocytosis-Like Inflammation in ZNFX1 Deficiency. [PDF]
Eur J ImmunolLCMV‐infected Znfx1‐deficient mice develop hemophagocytic lymphohistiocytosis (HLH)‐like immune dysregulation, mirroring key aspects of the immunopathology observed in ZNFX1‐deficient patients. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome characterized by persistent activation of lymphocytes and macrophages ...
Tintor D +9 more
europepmc +2 more sources
Relaxed Binaural LCMV Beamforming [PDF]
IEEE/ACM Transactions on Audio, Speech, and Language Processing, 2017 In this paper we propose a new binaural beamforming technique which can be seen as a relaxation of the linearly constrained minimum variance (LCMV) framework. The proposed method can achieve simultaneous noise reduction and exact binaural cue preservation of the target source, similar to the binaural minimum variance distortionless response (BMVDR ...
Koutrouvelis, A. (author) +3 more
openaire +8 more sources
Identification of the Lymphocytic Choriomeningitis Virus (LCMV) Proteins Required To Rescue LCMV RNA Analogs into LCMV-Like Particles [PDF]
Journal of Virology, 2002 ABSTRACT We have used a reverse genetic approach to identify the viral proteins required for packaging and assembly of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). Plasmids encoding individual LCMV proteins under the control of an RNA polymerase II promoter were cotransfected with a plasmid containing an ...
Lee, Ki Jeong +3 more
openaire +3 more sources
Local Maintenance and Genomic Diversity of Lymphocytic Choriomeningitis Virus in Natural Populations of House Mice in the Czech Republic Over a 24-Year Period. [PDF]
Zoonoses Public HealthABSTRACT Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent‐borne zoonotic virus primarily infecting house mice. The virus can be highly pathogenic, particularly in immunocompromised individuals and in congenital infections. LCMV is distributed worldwide but shows local clustering, probably due to the highly structured populations of its ...
Jezkova I +5 more
europepmc +2 more sources
Interrogating Adaptive Immunity Using LCMV
Current Protocols in Immunology, 2020 AbstractIn this invited article, we explain technical aspects of the lymphocytic choriomeningitis virus (LCMV) system, providing an update of a prior contribution by Matthias von Herrath and J. Lindsay Whitton. We provide an explanation of the LCMV infection models, highlighting the importance of selecting an appropriate route and viral strain. We also
Tanushree, Dangi +3 more
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Lymphocytic Choriomeningitis Virus (LCMV): Propagation, Quantitation, and Storage [PDF]
Current Protocols in Microbiology, 2008 AbstractLymphocytic choriomeningitis virus (LCMV) is an enveloped, ambisense RNA virus and the prototypic virus of the arenavirus group. It can cause viral meningitis and other ailments in humans, but its natural host is the mouse. The LCMV/mouse model has been useful for examining mechanisms of viral persistence and the basic concepts of virus‐induced
Welsh, Raymond M., Seedhom, Mina O.
openaire +3 more sources
Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review
Tropical Medicine and Infectious Disease, 2021 Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent-borne zoonotic virus distributed worldwide. Since serologic assays are limited to several laboratories, the disease has been underreported, often making it difficult to determine incidence ...
Tatjana Vilibic-Cavlek +9 more
doaj +1 more source
Frontiers in Immunology, 2013 The balance between protective immunity and immunopathology often determines the fate of the virus-infected host. How rapidly virus is cleared is a function of initial viral load, viral replication rate, and efficiency of the immune response.
Markus eCornberg +8 more
doaj +1 more source