Results 101 to 110 of about 44,701 (203)

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Safety Assessment of Ayurvedic Formulation “Annabedi chendooram” in Experimental Animals

Ancient Science of Life
Background: Annabhedī cendūram is a classical preparation that has been used since ancient times for anemia in Ayurvedic/Siddha practice. The safety profile of the compound in experimental animals has not been established completely.
Sudesh N. Gaidhani, N. Srikanth, Arjun Singh, P. V. Deshmukh, Viswanth Reddy, Gandhidas S. Lavekar, Srikanth Ala   +6 more
doaj   +1 more source

Metformin‐Based Covalent Organic Frameworks With Excellent Biosafety and High Efficiency against Pathogenic Microorganisms

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This work presents the first metformin‐based COFs featuring built‐in biosafety and a unique triple‐synergy mechanism. This scalable platform achieves broad‐spectrum eradication of bacteria and viruses, enabling reusable protective membranes with exceptional biocompatibility for advanced biomedical applications and personal protection.
Jia‐Yi Liu, Hong Jiang, Lei Ma, Jin‐Yi Yu, Ming‐Yi Yang, Hao‐Ru Wang, Jun‐Yuang Tang, Shengfeng Huang, Wei Yi, Meng Lu, Ya‐Qian Lan, Xu‐Jia Hong   +11 more
wiley   +1 more source

Phytochemical Analysis of Veratrum Alkaloids in Medicinal Veratrum Globules Using High‐Performance Liquid Chromatography Coupled With Tandem Mass Spectrometry

Biomedical Chromatography, Volume 40, Issue 3, March 2026.
ABSTRACT Veratrum L. species have been used in traditional medicine for centuries due to their bioactive properties, yet they also contain toxic steroid alkaloids that pose potential health risks when present in herbal preparations. Reliable analytical approaches are therefore essential to ensure product safety, protect consumer health and assess ...
Julia Siegle, Jörg Pietsch
wiley   +1 more source

Aeromonas hydrophila dose and post-immunostimulation period as immunomodulatory effect indicator on Nile tilapia (Oreochromis niloticus)

Pesquisa Agropecuária Gaúcha
In fish challenge tests, there is no standardization in the concentration and analysis period of parameters. This study investigates the immunomodulatory and cytotoxic effects of A. hydrophila dose and postimmunostimulation periods on Nile tilapia. Four
Erika do Carmo Ota, Luis Antonio Kioshi Aoki Ionue, Ricardo Basso Zanon, Fernanda Sotolani Suares, Tarcila Souza de Castro Silva   +4 more
doaj   +1 more source

Cytotoxic, Genotoxic, and Mutagenic Effects of Organotellurane RF07 in Female Swiss Mice (Mus musculus)

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT The organotellurane RF07 (RF07) is an organic compound containing tellurium, a rare semi‐metal, and its leishmanicidal and antimalarial activity has already been reported in previous studies. This study evaluated the toxic effects of RF07 at 0.42, 21.37, and 42.75 mg/kg using comet assay, micronucleus test, and hematological/biochemical tests ...
Felipe Emannuel Alvino de Jesus, Octávio Augusto de Carvalho Maia, Rosália Maria Tôrres de Lima, Ag‐Anne Pereira Melo de Meneses, Audinei de Sousa Moura, Antonielly Campinho dos Reis, Maria Luísa Lima Barreto do Nascimento, Taline Alves Nobre, Athanara Alves de Sousa, Shamya Gabriella Corrêa Coelho, Glissia Lysandra dos Santos Marciel, Isabela Ribeiro de Sá Guimarães Nolêto, Adriana Maria Viana Nunes, Rodrigo Luiz Oliveira Rodrigues Cunha, Pedro Marcos de Almeida, Diego Di Felipe Ávila Alcantara, João Marcelo de Castro e Sousa   +16 more
wiley   +1 more source

CA IX Inhibition by a Sulfonamide Compound: A Therapeutic Approach Against Breast Cancer

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
Synergistic Efficacy of MMH‐I and 5‐Fluorouracil Combination Therapy in CA IX‐Expressing Breast Cancer Models: Pathological and Metabolic Insights. ABSTRACT Carbonic anhydrase IX (CA IX) is overexpressed in many solid tumors, contributing to cancer cell proliferation, survival, invasion, and metastasis.
Sükrü Akmese, Ebru Temiz, Elif Gürel, Ismail Koyuncu, Mustafa Durgun, Muhammet Emin Guldur, Kadir Egi, Beyza Ozerol   +7 more
wiley   +1 more source

GABAergic Modulation and Neurobehavioral Effects of Arjunolic Acid, a Pentacyclic Triterpene Isolated From Combretum Mellifluum Eichler: In Vivo and Molecular Docking Evaluation

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT This study investigated the neuropharmacological effects of arjunolic acid, with a particular focus on its anxiolytic and anticonvulsant properties. To this end, in vivo tests were performed on adult zebrafish (Danio rerio) and in silico molecular docking analyses were conducted.
Yanna Julie da Silva Freitas, Jéssica Bezerra Maciel, Maria Eduarda Uchoa Bezerra, Victor Moreira de Oliveira, Simone Alves Serafim Rocha, Otília Loiola Pessoa, Marcia Machado Marinho, Emmanuel Silva Marinho, Cléia Rocha de Sousa Feitosa, Jane Eire Silva Alencar de Menezes, Andreia Ferreira de Castro Gomes, Hélcio Silva dos Santos   +11 more
wiley   +1 more source

Vitex Simplicifolia Abates Cadmium‐Induced Cardiotoxicity Through Antioxidant Activity and Keap1 Targeting

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT This study evaluated the cardioprotective potential of Vitex simplicifolia methanol extract (VSME) and explored its underlying mechanisms of action. Twenty‐five male rats were assigned to five groups (n = 5). Group 1 served as the normal control, while groups 2–5 were exposed to 5 mg/kg body weight of cadmium chloride (CdCl2) daily.
Ifeoma F. Chukwuma, Okechukwu Ignatius Eze, Ogechukwu Colet Okeke, Victor O. Apeh, Timothy Prince Chidike Ezeorba, Chima Okafor   +5 more
wiley   +1 more source

Emex spinosa (L.) Campd.: A Review on Ethnomedicinal, Phytochemical, Pharmacological, and Toxicological Profile

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
Graphical abstract illustrating the pharmacological potential of E. spinosa. ABSTRACT Emex spinosa (L.) Campd. (E. spinosa) is a plant species belonging to the Polygonaceae family. It is native to the Middle East, North Africa, and Europe and is most commonly seen on the coastlines of Mediterranean countries.
Smail Amtaghri, Kolawole Olofinsan, Mitchel Otieno Okumu, Kopang Clemendi Mokhetho, Shabnoor Iqbal, Innocensia M. Mangoato, Mohamed Amtaghri, Mouloud Lamtai, Mohamed Yassine El Brouzi, Motlalepula G. Matsabisa   +9 more
wiley   +1 more source