Results 201 to 210 of about 61,903 (248)

Synthesis of Chalcone‐Sulfonamide Hybrids as Antibacterial, Antioxidant, and Anti‐Inflammatory Agents With Comprehensive In Silico and ADMET Profiling

ChemistryOpen, Volume 15, Issue 9, September 2026.
Eight chalcone‐sulfonamide hybrids (12a–h) are synthesized via Claisen–Schmidt condensation and evaluated for antibacterial, antioxidant, and anti‐inflammatory activity. The compounds show potent radical scavenging, strong protein‐denaturation inhibition surpassing diclofenac, and favorable docking against DHPS, myeloperoxidase, COX‐2, and ...
Mlis Belete, Endale Mulugeta, Daniel Rentsch, Muhdin Aliye, Kebede Shenkutie, Yadessa Melaku   +5 more
wiley   +1 more source

Reproductive toxicity of a nano-insecticide (chlorpyrifos) on male albino mice. [PDF]

Sci Rep
Ahmed MA, Kandeel AA, Tawfik WS.
europepmc   +1 more source

Machine learning driven LD₅₀ prediction for cancer risk assessment using modern molecular language models. [PDF]

Front Oncol
Sharma T, Sona P, Jung J.
europepmc   +1 more source

YK‐4‐250, a synthetic telmisartan–tempol conjugate: crystal structure of a stabilized free radical containing an angiotensin AT1 receptor inhibitor

Acta Crystallographica Section C, Volume 82, Issue 9, Page 547-552, September 2026.
The first crystal structure of the telmisartan–tempol conjugate YK‐4‐250 is reported, revealing the intramolecular C–H…π interactions that stabilize the nitroxide radical while preserving the angiotensin AT1 receptor antagonist pharmacophore.We report the first crystal structure of the telmisartan–tempol conjugate 2,2,6,6‐tetramethyl‐1‐(λ′‐oxidaneyl ...
Simon Friedrich, Yali Kong, Faik N. Musayev, Milton L. Brown, B. Frank Gupton   +4 more
wiley   +1 more source

The Role of Systemic Inflammation in Paracetamol Poisoning-An Experimental Model. [PDF]

Int J Mol Sci
Zudova A, Apanovich S, Mukhlynina E, Solomatina L, Gusev E.   +4 more
europepmc   +1 more source

Acute heat tolerance (CTmax) of two invasive parasitic copepods differs across species, life cycle stages and acclimation temperatures

Functional Ecology, Volume 40, Issue 9, Page 2793-2803, September 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Climate change is increasing the frequency and severity of heatwaves with potential consequences for host–parasite dynamics. While the acute heat tolerance of free‐living organisms has been intensively studied, much less is known about it for parasites and their life ...
Elli Rosa Jolma, Antoine Grenier‐Journe, Ana Born‐Torrijos, David W. Thieltges   +3 more
wiley   +1 more source

Biological Profile of Ferulic Acid-Based Thiazolidin-4-One Derivatives: Toxicity, Inflammation, and Oxidative Stress Biomarkers. [PDF]

Molecules
Dragan M, Iacob AT, Mircea C, Stan CD, Dragostin OM, Focșa AV, Tatarciuc D, Stan RT, Poroch M, Profire L.   +9 more
europepmc   +1 more source

Mycotoxins in Basidiomycete Mycelium and Fruiting Bodies: Implications for Eu Novel Food Assessment and Selected International Regulatory Frameworks

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT Advances in technology have enabled the efficient and sustainable production of basidiomycete vegetative mycelium, particularly from Pleurotus species, as a novel food source. However, mycelium has yet to receive regulatory approval in many global markets, requiring a better understanding of factors affecting its safety.
Niklas Erik Wilhelm Berglund, Pauliina Vappu Lankinen, Kirsi Susanna Mikkonen   +2 more
wiley   +1 more source

The Evolution of Knockdown Resistance: Genotypic and Phenotypic Insights Into <i>Aedes aegypti</i> Insecticide Resistance. [PDF]

Evol Appl
Jensen BM, Estep AS, Huijben S.
europepmc   +1 more source

Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐Yl) Derivatives as EGFR Inhibitors Targeting EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S in NSCLC

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
Rational Design, Synthesis, Biological Evaluation, and In Silico Investigation of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐yl) Derivatives as EGFR Inhibitors Targeting Wild‐Type and Mutant EGFR in NSCLC. ABSTRACT Non‐small cell lung cancer (NSCLC), driven by mutations in the epidermal growth factor receptor ...
Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Ghanshyam Teli, Manjushree BV, Anguraj Moulishankar, Viney Chawla, Pooja A. Chawla   +6 more
wiley   +1 more source