Results 211 to 220 of about 61,903 (248)

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Investigation of Benzisothiazole‐Based Hydrazide Derivatives as Potential Anti‐Tuberculosis Agents

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
A novel series of benzisothiazole‐based hydrazide derivatives was designed, synthesized, and evaluated for antitubercular activity. Compound 8k emerged as the most potent candidate (MIC = 0.25 μg/mL) with a high selectivity index (SI = 42) and bactericidal activity. Molecular docking and 100 ns simulations identified InhA as the probable target.
Vivek Sharma, Arun Sharma, Ruchi Poria, Pardeep Kumar   +3 more
wiley   +1 more source

From chemotype to control: insecticidal efficacy of piperitone and 2-cyclohexen-1-one analogues against dual-stage stored-product pests. [PDF]

Sci Rep
Lee NH, Munkhtur E, Chung N, Lee HS.
europepmc   +1 more source

From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Twelve N‐acylhydrazone derivatives (5a–f, 6a–f) were synthesized and characterized. Compounds displayed potent submicromolar inhibition against both MAO‐A and MAO‐B. Compound 6e exhibited the strongest activity (IC50 = 0.073 μM for MAO‐A; 0.064 μM for MAO‐B). Kinetic and docking analyses confirmed reversible, competitive inhibition via FAD interaction.
Hasan Erdinç Sellitepe, Ahmet Buğra Aksel, Ezgi Pehlivanlar Yavrucu, Hilal Zıvalı, Begüm Nurpelin Sağlık Özkan, İnci Selin Doğan   +5 more
wiley   +1 more source

Development of a Controlled-Dose Aerosol Challenge Method Using a Lung Fluid Quantitative Nebulizer. [PDF]

Microorganisms
Shao M, Cui H, Chen Z, Zhang L, Zhang C, Guo Z, Han P.   +6 more
europepmc   +1 more source

Medicinal and Crop Protection Chemistry: Breaking Barriers, Building Synergies

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A unified view of medicinal and crop protection chemistry reveals shared scientific progress, common challenges, and new opportunities for cross‐disciplinary collaboration. Bridging expertise across both fields could accelerate innovation and actively encourage more sustainable solutions.
Giulia Cazzaniga, Giusy L. Fratello, Alexander T. Apostle, Roberto Orru, David M. Barber, Silvia Gazzola   +5 more
wiley   +1 more source

Discovery of natural product-derived pesticide candidates: synthesis, aphicidal activity, and toxicological evaluation of andrographolide derivatives. [PDF]

Pest Manag Sci
Zhang W, Song XX, Zhang WH, Zhou XR, Yuan W, Zhang J, Kong WB, Liang JY, Wu F.   +8 more
europepmc   +1 more source

Highly efficient intranasal H5N1 vaccine based on a safe vesicular stomatitis virus (VSV) vector. [PDF]

Signal Transduct Target Ther
Liang Z, Zhang M, Zhang J, Chen H, Chen J, Tang C, Tong J, Wu X, Liu S, Nie L, Li Q, Nie J, Lu S, Huang W, Wang Y.   +14 more
europepmc   +1 more source

Glycoprotein G enables HSV-2 neuroinvasion and provides protection as a glycosylated vaccine antigen. [PDF]

PLoS Pathog
Könighofer E, Gustafsson C, Gudmundsdotter L, Mirgorodskaya E, Nilsson J, Ekblad M, Adamiak B, Jennische E, Lange S, Trybala E, Görander S, Bergström T, Liljeqvist JÅ, Nordén R.   +13 more
europepmc   +1 more source

Structural Preferences and ADMET Regulation of Fluorinated Small-Molecule Drugs. [PDF]

ACS Med Chem Lett
Tao S, Wei L, Wu Y, Lian X, Wu J, Liu Y, Wu F.   +6 more
europepmc   +1 more source

Toxic and repellent effects of hemp leaf extracts and cannabidiol against adult female yellow fever mosquitoes, Aedes aegypti. [PDF]

PLoS One
Martínez Rodríguez EJ, Phelan PL, Canas L, Acosta N, Feliciano PN, Tubbs J, Loperena E, Rakotondraibe HL, Piermarini PM.   +8 more
europepmc   +1 more source