Results 51 to 60 of about 750,498 (385)

Achievement of LDL-C Targets Defined by ESC/EAS (2011) Guidelines in Risk-Stratified Korean Patients with Dyslipidemia Receiving Lipid-Modifying Treatments [PDF]

Endocrinology and Metabolism, 2020
Background This study assessed the proportion of risk-stratified Korean patients with dyslipidemia achieving their low-density lipoprotein cholesterol (LDL-C) targets as defined by the European Society of Cardiology/European Atherosclerosis Society (ESC ...
Ye Seul Yang, Seo Young Lee, Jung-Sun Kim, Kyung Mook Choi, Kang Wook Lee, Sang-Chol Lee, Jung Rae Cho, Seung-Jin Oh, Ji-Hyun Kim, Sung Hee Choi   +9 more
doaj   +1 more source

LDL Receptors in Keratinocytes

Journal of Investigative Dermatology, 1992
The presence of sufficient amounts of cholesterol in the epidermis is necessary for proper functioning of plasma membranes in the viable epidermal cell layers and also for the barrier quality of lipid intercellular bilayers of the stratum corneum. Cholesterol can be generated by local epidermal synthesis, or imported from the circulation as low-density
Maria Ponec, Bert J. Vermeer, Louis Havekes, A. Mieke Mommaas, Johannes Boonstra, Marinus F W Te Pas   +5 more
openaire   +3 more sources

Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia and LDL-C of 160 mg/dl or Higher

Cardiovascular Drugs and Therapy, 2016
PurposeEven with statins and other lipid-lowering therapy (LLT), many patients with heterozygous familial hypercholesterolemia (heFH) continue to have elevated low-density lipoprotein cholesterol (LDL-C) levels. ODYSSEY HIGH FH (NCT01617655) assessed the
H. Ginsberg, D. Rader, F. Raal, J. Guyton, M. Baccara-Dinet, C. Lorenzato, R. Pordy, E. Stroes   +7 more
semanticscholar   +1 more source

PCSK9 inhibition-mediated reduction in Lp(a) with evolocumab: an analysis of 10 clinical trials and the LDL receptor’s role[S]

Journal of Lipid Research, 2016
Lipoprotein (a) [Lp(a)] is independently associated with CVD risk. Evolocumab, a monoclonal antibody (mAb) to proprotein convertase subtilisin/kexin type 9 (PCSK9), decreases Lp(a). The potential mechanisms were assessed.
F. Raal, R. Giugliano, M. Sabatine, M. Koren, D. Blom, N. Seidah, Narimon Honarpour, Armando Lira, Allen Xue, P. Chiruvolu, Simon Jackson, Mei Di, M. Peach, R. Somaratne, S. Wasserman, R. Scott, E. Stein   +16 more
semanticscholar   +1 more source

Relationship between Physical Activity and Blood Lipid Profile in Residents of Yazd City (YaHS Study)

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020
Introduction: Inadequate physical activity is one of the causes of fat disorders and regular physical activity is one of the important factors in correcting fat disorders.
Masoud Mirzaei, Farnaz Nekahi
doaj  

A Meta-Analysis of eHealth Interventions on Ischaemic Heart Disease Health Outcomes

Global Heart, 2023
Background: Electronic Health (eHealth) interventions as a secondary prevention tool to empower patients’ health in decision-making and behaviour. Objective: With the growing body of evidence supporting the use of eHealth interventions, the intention is ...
Puteri Sofia Nadira Megat Kamaruddin, Azmawati Mohammed Nawi, Mohd Rizal Abdul Manaf, Mohamad Nurman Yaman, Abdul Muizz Abd Malek   +4 more
doaj   +1 more source

Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester [PDF]

, 2013
Context: Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density ...
Brown, E.A., Caslake, M.J., Cooney, J., Freeman, D.J., Griffin, B.A., Meyer, B.J., Nilsson, S., Olivecrona, G., Ramsay, J.E., Stewart, F.M.   +9 more
core   +2 more sources

High bone density due to a mutation in LDL-receptor-related protein 5.

New England Journal of Medicine, 2002
BACKGROUND Osteoporosis is a major public health problem of largely unknown cause. Loss-of-function mutations in the gene for low-density lipoprotein receptor-related protein 5 (LRP5), which acts in the Wnt signaling pathway, have been shown to cause ...
L. Boyden, J. Mao, J. Belsky, L. Mitzner, Anita Farhi, M. Mitnick, Dianqing Wu, K. Insogna, R. Lifton   +8 more
semanticscholar   +1 more source

Ezetimibe therapy: mechanism of action and clinical update. [PDF]

, 2012
The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in the primary and secondary prevention of cardiovascular events.
Dayspring, Thomas D, Phan, Binh An P, Toth, Peter P   +2 more
core   +1 more source

Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells

Nature Communications, 2016
In humans and animals lacking functional LDL receptor (LDLR), LDL from plasma still readily traverses the endothelium. To identify the pathways of LDL uptake, a genome-wide RNAi screen was performed in endothelial cells and cross-referenced with GWAS ...
Jan R. Kraehling, J. Chidlow, Chitra Rajagopal, Michael G. Sugiyama, J. W. Fowler, Monica Y. Lee, Xinbo Zhang, C. Ramírez, E. Park, Bo Tao, Keyang Chen, Leena Kuruvilla, B. Larrivée, E. Folta-Stogniew, Roxana Ola, N. Rotllan, Wenping Zhou, Michael W. Nagle, J. Herz, K. Williams, A. Eichmann, Warren L. Lee, C. Fernández-Hernando, W. Sessa   +23 more
semanticscholar   +1 more source