Results 171 to 180 of about 230,793 (312)
Effect of type 2 diabetes on the inducible degrader of LDL receptor. [PDF]
J Lipid Res, 2023 Lam S +4 more
europepmc +1 more source
Interleukin-4 Deficiency Decreases Atherosclerotic Lesion Formation in a Site-Specific Manner in Female LDL Receptor−/− Mice [PDF]
, 2002 Victoria King +2 more
openalex +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.From the nationwide multicenter consortium, 8,163 patients undergoing drug‐eluting stent implantation were classified according to the presence of the CYP2C19 loss‐of‐function (LoF) allele: rapid or normal metabolizers (RMs/NMs) vs. intermediate or poor metabolizers (IMs/PMs), and clinical risk was stratified using the CHADS‐P2A2RC and TRS 2°P scores ...
Hyun Woong Park +22 more
wiley +1 more source
Predominantly Increased Triglyceride-rich Lipoproteins Induced by Dietary Cholesterol Promoted Atherosclerosis Formation in LDL Receptor Knockout Golden Hamster [PDF]
, 2021 Yuhui Wang +10 more
openalex +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka +12 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz +15 more
wiley +1 more source
The discovery of PCSK9 inhibitors: A tale of creativity and multifaceted translational research. [PDF]
, 2013 Elguindy, A, Yacoub, MH
core +1 more source
Maternal Gestational Low‐Grade Inflammation and the Risk of Anorexia Nervosa in Daughters
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Prenatal exposures have been suggested to have a programming effect on neural and metabolic development, which may affect the risk of eating disorders. We investigated the association between prospectively measured maternal gestational high‐sensitivity C‐reactive protein (hs‐CRP), an established inflammatory biomarker, and subsequent
Emma Saure +6 more
wiley +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Autophagy regulates MK-2206-induced LDL receptor expression and cholesterol efflux pathways. [PDF]
PLoS OneSundvold H, Strøm TB.
europepmc +1 more source