Results 171 to 180 of about 2,612,734 (405)

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

2D-NMR reveals different populations of exposed lysine residues in the apoB-100 protein of electronegative and electropositive fractions of LDL particles[S]

Journal of Lipid Research, 2010
Several potentially atherogenic LDL subfractions present low affinity for the LDL receptor, which result in impaired plasma clearance. Electronegative LDL [LDL(−)] is one of these minor subfractions and the molecular basis for its reduced receptor ...
Francisco J. Blanco, Sandra Villegas, Sònia Benítez, Cristina Bancells, Tammo Diercks, Jordi Ordóñez-Llanos, José L. Sánchez-Quesada   +6 more
doaj  

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

, 1987
Robert E. Pitas, J K Boyles, S H Lee, David Y. Hui, Karl H. Weisgraber   +4 more
openalex   +1 more source

Assessing the link of malnutrition with diabetes and mortality risk in heart failure patients

ESC Heart Failure, EarlyView.
Abstract Aims Malnutrition is increasingly recognized as a significant factor influencing the clinical outcomes of patients with heart failure (HF). Diabetes exacerbates risks like hospitalizations and mortality due to cardiovascular complications. The aim of this study was to explore the association of malnutrition with diabetes and its prognostic ...
Konstantinos Prokopidis, Yang Chen, Yang Liu, Ziyi Zhong, Jordi Morwani‐Mangnani, Daniel J. Cuthbertson, Rajiv Sankaranarayanan, Gregory Y.H. Lip, Masoud Isanejad   +8 more
wiley   +1 more source

The beta-VLDL receptor pathway of murine P388D1 macrophages.

Journal of Lipid Research, 1988
Very low density lipoproteins Sf 100-400 (VLDL1) from hypertriglyceridemic (HTG) subjects and chylomicrons cause receptor-mediated lipid engorgement in unstimulated macrophages in vitro via the beta-VLDL receptor pathway.
S H Gianturco, S A Brown, D P Via, W A Bradley   +3 more
doaj  

Immune Checkpoint Inhibitors and Cardiovascular Adverse Events

ESC Heart Failure, EarlyView.
Abstract In the last years, we assisted to a tremendous increase in therapeutic options for the management of cancers, with immunotherapy at the forefront of this innovation. Immune checkpoint inhibitors (ICIs) have been developed to enhance the activity of the immune system against cancer cells (1) and the number of approvals for ICIs has rapidly ...
Maria Luisa De Perna, Elia Rigamonti, Raffaele Zannoni, Vittoria Espeli, Giorgio Moschovitis   +4 more
wiley   +1 more source

Minimally oxidized LDL inhibits macrophage selective cholesteryl ester uptake and native LDL-induced foam cell formation[S]

Journal of Lipid Research, 2014
Scavenger receptor-mediated uptake of oxidized LDL (oxLDL) is thought to be the major mechanism of foam cell generation in atherosclerotic lesions. Recent data has indicated that native LDL is also capable of contributing to foam cell formation via low ...
Jason M. Meyer, Ailing Ji, Lei Cai, Deneys R. van der Westhuyzen   +3 more
doaj  

BUN‐to‐ALB ratio as an effective predictor of 30 day mortality in ADHF patients in eastern China

ESC Heart Failure, EarlyView.
Abstract Aims The blood urea nitrogen‐to‐albumin ratio (BAR) is considered a potential indicator for assessing the poor prognosis of heart failure (HF). However, its prognostic value for Chinese patients with acute decompensated HF (ADHF) remains unclear.
Xin Huang, Chao Wang, Shiming He, Guoan Jian, Kun Jiang, Zihao Lu, Guotai Sheng, Yang Zou, Guobo Xie   +8 more
wiley   +1 more source

Modified low density lipoprotein isolated from atherosclerotic lesions does not cause lipid accumulation in aortic smooth muscle cells.

Journal of Lipid Research, 1991
Foam cells in atherosclerotic lesions are derived not only from blood monocytes but also from smooth muscle cells (SMC). To better understand the mechanisms by which SMC may become lipid-laden, we have studied the catabolism by cultured rabbit aortic SMC
HF Hoff, JM Pepin, RE Morton
doaj  

Carbon Nanodots Attenuate Lipid Peroxidation in the LDL Receptor Knockout Mouse Brain. [PDF]

Antioxidants (Basel), 2023
Erikson KM, El-Khouri K, Petric R, Tang C, Chen J, Vasquez DEC, Fordahl SC, Jia Z.   +7 more
europepmc   +1 more source