Results 111 to 120 of about 3,458,304 (355)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Ease Leads to Exposure. Exposure Leads to Adoption

, 2019
ESIP Summer Meeting 2019 plenary remarks about getting people to actually USE the resources that we’ve worked so very hard to build, and thus is in keeping with the conference theme: “Data to Action: Increasing the Use and Value of Earth Science Data and Information.” As we seek to increase the USE and VALUE of Earth science data and information, a ...
openaire   +1 more source

No association between prenatal lead exposure and neurodevelopment during early childhood in the Japan Environment and Children’s Study [PDF]

, 2022
Hirosuke Inoue, Masafumi Sanefuji, Yuri Sonoda, Masanobu Ogawa, Norio Hamada, Masayuki Shimono, Reiko Suga, Shoji F. Nakayama, Yu Taniguchi, Koichi Kusuhara, Shouichi Ohga, Michihiro Kamijima, Michihiro Kamijima, Shin Yamazaki, Yukihiro Ohya, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni Inadera, Takeo Nakayama, Hiroyasu Iso, Masayuki Shima, Hiroshige Nakamura, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh, Takahiko Katoh   +29 more
openalex   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Association of cadmium and lead exposure with mortality in cancer survivors: A prospective cohort study

Ecotoxicology and Environmental Safety
Lead and cadmium are well-documented for their carcinogenic properties and their potential to induce cellular malignancy. Nevertheless, there is a paucity of research examining the correlation between blood cadmium and lead levels and the prognostic ...
Yifei Yan, Liuyin Jin, Jianchang Li, Guopeng Chen   +3 more
doaj   +1 more source

Lead exposure and drug addiction [PDF]

, 2014
La sostenida reducción a lo largo de los años en los niveles de referencia de plomo (Pb) en sangre considerados “seguros” para los organismos en desarrollo revela la creciente preocupación por los efectos subclínicos resultantes de la exposición a este ...
Cancela, Liliana Marina, Virgolini, Miriam Beatriz   +1 more
core  

Sex-Specific Effects of a Wartime-Like Radiation Exposure on Cognitive Function. [PDF]

, 2020
Evaluating the risk for central nervous system (CNS) effects after whole-body or partial-body irradiation presents challenges due in part to the varied exposure scenarios in the context of occupational, accidental or wartime releases.
Acharya, Munjal M, Alikhani, Leila, Apodaca, Lauren A, Baddour, Al Anoud D, Batra, Raja S, Baulch, Janet E, Lu, Celine, Minasyan, Harutyun   +7 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Association between Chronic Environmental Lead (Pb) Exposure and Cytokines in Males and Females of Reproductive Age from Kabwe, Zambia [PDF]

, 2023
Andrew Kataba, Yared Beyene Yohannes, Hokuto Nakata, John Yabe, Haruya Toyomaki, Kaampwe Muzandu, Golden Zyambo, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka, Shouta M.M. Nakayama   +10 more
openalex   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source