Results 101 to 110 of about 415,916 (299)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Differences In Piping System Design for Reciprocating and Centrifugal Pumps [PDF]

open access: yes, 2018
Short CourseReciprocating pump installations require particular design considerations which are much different from centrifugal pump systems. An incomplete design basis for reciprocating pump installations can lead to costly remedial actions after ...
Newman, Tom   +2 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

What drives lead users to become users entrepreneurs ? an exploratory study of motivations

open access: yes, 2012
CAHIER DE RECHERCHE n°2012-01 E3Regardless the type of industry, it has been shown that users, and more specifically lead users, are among the prime developers of truly novel solutions.
Hamdi-Kidar, Linda, Vellera, Cyrielle
core   +1 more source

Comparative Analysis of Inflammatory and Heavy Metal Biomarkers in Exclusive E-Cigarette Users, Combustible Tobacco Users, and Non-Users Aged 18–30: A Cross-Sectional NHANES Analysis

open access: yesJournal of Xenobiotics
While cigarette smoking has declined, e-cigarette use among young adults has increased in the USA. This cross-sectional study compared complete blood counts, C-reactive protein, and select blood metals (lead, cadmium, mercury, selenium, manganese) among ...
Luke Manietta   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

ARE USERS THE NEXT ENTREPRENEURS? A CASE STUDY ON THE VIDEO GAME INDUSTRY. [PDF]

open access: yes
Knowledge based-entrepreneurial firms struggle to survive because they must be simultaneously entrepreneurial on several dimensions. Can those firms rely on users to achieve sufficient efficiency in some entrepreneurial dimensions?
Thierry BURGER-HELMCHEN, Claude GUITTARD
core  

Innovation From Employee User’s Work Behavior:

open access: yesMaketingu Janaru
Previous studies have frequently reported that non-R&D employees are often involved in innovation, particularly by leveraging their knowledge as users.
Ryohei Yonemitsu
doaj   +1 more source

Random Access Control for M2M in LTE System

open access: yesInternational Journal of Distributed Sensor Networks, 2013
With the implementation of 4G mobile networks, the number of M2M users will be much large in a cell. When massive M2M users try to randomly access simultaneously, this will impose a great influence on H2H communication.
Zhide Chen, Yali Zeng
doaj   +1 more source

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