Results 121 to 130 of about 415,916 (299)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Understanding international crime trends: The legacy of preschool lead exposure
This study shows a very strong association between preschool blood lead and subsequent crime rate trends over several decades in the USA, Britain, Canada, France, Australia, Finland, Italy, West Germany, and New Zealand. The relationship is characterized
Nevin, Rick
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, 2007 The purpose of this thesis was to study strategies that companies can use to incorporate business lead users into the new product development process and in this way improve the performance of new product development.
Mattila, Daniel, Dignell, Mårten
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Characteristics of innovating users in a consumer goods field: An empirical study of sport-related product consumers [PDF]
We report on a survey of the innovation activities and characteristics of 153 users of outdoor-related consumer products. We find a high level of innovation by these consumers.
Lüthje, Christian
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A COMPARISON OF 12 LEAD ECG STATUS OF TOBACCO SMOKERS, TOBACCO CHEWERS AND NONTOBACCO USERS
National Journal of Medical Research, 2013 Introduction: According to World Health Report (2002)1 tobacco is the most preventable cause of overall mortality as well as cardiovascular mortality worldwide.
Salamn S Siddiqui +3 more
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Lead Poisoning among Opium Users in Iran, a Possible New Emerging Epidemic in the Region
Iranian Journal of Public Health, 2017 Please provide alternate text for this image to ensure accessibility for users with text-only browsers or assistive devices.
Seyed Ramin RADFAR +3 more
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The process of user-innovation: A case study on user innovation in a consumer goods setting [PDF]
Manufacturers usually benefit by dividing their innovation processes into distinct phases in order to ensure that the development activities are performed efficiently in an appropriate sequence. Users usually do not apply such structured processes.
Tietz, Robert +3 more
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