Results 41 to 50 of about 14,545 (212)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Impact of Social Exchange on Referees’ Job Satisfaction: Mediating Effect of Organizational Trust

SAGE Open
The purpose of the current study was to examine how perceived organizational support and leader-member exchange influence job satisfaction through organizational trust among sport referees.
Xuan Liu, Seungmo Kim, Adam Love
doaj   +1 more source

Improving Organizational Citizenship Behavior through Job Satisfaction, Leader-Member Exchange, and Work-Life Balance

Binus Business Review, 2020
The research aimed to analyze the effect of leader-member exchange, work-life balance, and job satisfaction on Organizational Citizenship Behavior (OCB). The respondents were nursing staff at a hospital in Indonesia.
Heriyadi Heriyadi, Heru Kurnianto Tjahjono, Meika Kurnia Puji Rahayu   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The influence of despotic leadership on innovative behavior in Ho Chi Minh City businesses: The mediating role of leader-member exchange

Ho Chi Minh City Open University Journal of Science - Economics and Business Administration
This study examines the impact of despotic leadership on employees’ innovative behavior, with a particular focus on the mediating role of leader-member exchange in businesses based in Ho Chi Minh City. Based on the social exchange theory, conservation of
Anh Tuan Tran, Thinh Thi Thu Duong, Minh Thi Binh Nguyen   +2 more
doaj   +1 more source

Uji Validitas Konstruk Leader Member Eexchange – Multi-Dimensional Measure (LMX-MDM)

Jurnal Pengukuran Psikologi dan Pendidikan Indonesia, 2016
This study tested construct validity of LMX-MDM (leader member exchange-multidimensional measure). LMX (leader member exchange) has four dimensions, and those are affect, loyalty, contribution, and professional respect with 24 items.
Jonny Pranata
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Peran Leader-Member Exchange (LMX) dan Occupational Stress untuk Memprediksi Intensi Turnover

Gadjah Mada Journal of Psychology, 2019
The aim of this study was to examine the effect of leader-member exchange (LMX) and occupational stress on the turnover intention on PT. Komatsu Indonesia’s employees.
Ramadhan Ulfah Widyaningsih, Ridwan Saptoto   +1 more
doaj   +1 more source