Results 11 to 20 of about 2,058,783 (273)

Data-Driven Subtyping of Executive Function-Related Behavioral Problems in Children. [PDF]

open access: yes, 2018
OBJECTIVE: Executive functions (EF) are cognitive skills that are important for regulating behavior and for achieving goals. Executive function deficits are common in children who struggle in school and are associated with multiple neurodevelopmental ...
Astle, Duncan E   +3 more
core   +1 more source

Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies

open access: yeseLife, 2017
Simultaneous stimulation of the antennal lobes (ALs) and the ascending fibers of the ventral nerve cord (AFV), two sensory inputs to the mushroom bodies (MBs), induces long-term enhancement (LTE) of subsequent AL-evoked MB responses.
Kohei Ueno   +5 more
doaj   +1 more source

Interleukin-6 deficiency exacerbates Huntington’s disease model phenotypes

open access: yesMolecular Neurodegeneration, 2020
Huntington’s disease (HD) is an incurable neurodegenerative disorder caused by CAG trinucleotide expansions in the huntingtin gene. Markers of both systemic and CNS immune activation and inflammation have been widely noted in HD and mouse models of HD ...
Mary H. Wertz   +5 more
doaj   +1 more source

Cingulate-motor circuits update rule representations for sequential choice decisions

open access: yesNature Communications, 2022
The anterior cingulate cortex allows an animal to update its behaviour when the environment changes. In this work, the authors identify a pathway from cingulate to secondary motor cortex, critical for updating motor rules following behavioural errors.
Daigo Takeuchi   +8 more
doaj   +1 more source

Chemosensory learning and memory [PDF]

open access: yesFrontiers in Systems Neuroscience, 2012
The aim of this issue is to present an updated view of present knowledge and questions raised in the rapidly expanding field of chemosensory (taste and olfactory) learning. Taste is a powerful primary (unlearned) reinforcer, and topics such as olfactory-taste and visual taste association learning are covered in this issue.
Gallo, Milagros, Rolls, Edmund
openaire   +3 more sources

The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons

open access: yesCell Reports, 2017
The histone deacetylase HDAC2, which negatively regulates synaptic gene expression and neuronal plasticity, is upregulated in Alzheimer’s disease (AD) patients and mouse models.
Hidekuni Yamakawa   +9 more
doaj   +1 more source

Optogenetic insights on the relationship between anxiety-related behaviors and social deficits

open access: yesFrontiers in Behavioral Neuroscience, 2014
Many psychiatric illnesses are characterized by deficits in the social domain. For example, there is a high rate of co-morbidity between autism spectrum disorders and anxiety disorders.
Stephen Azariah Allsop   +4 more
doaj   +1 more source

Structural MRI Correlates of Episodic Memory Processes in Parkinson's Disease Without Mild Cognitive Impairment. [PDF]

open access: yes, 2015
BackgroundChanges in episodic memory are common early in Parkinson's disease (PD) and may be a risk factor for future cognitive decline. Although medial temporal lobe (MTL) memory and frontostriatal (FS) executive systems are thought to play different ...
Filoteo, J Vincent   +3 more
core   +2 more sources

Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior

open access: yesNature Communications, 2020
The neural circuit mechanisms for sensorimotor control by the prefrontal cortex (PFC) are unclear. Here, the authors show that PFC outputs to the visual cortex and superior colliculus respectively facilitate sensory processing and action selection ...
Rafiq Huda   +9 more
doaj   +1 more source

High-resolution analysis of individual Drosophila melanogaster larvae uncovers individual variability in locomotion and its neurogenetic modulation

open access: yesOpen Biology, 2023
Neuronally orchestrated muscular movement and locomotion are defining faculties of multicellular animals. Due to its simple brain and genetic accessibility, the larva of the fruit fly Drosophila melanogaster allows one to study these processes at ...
Michael Thane   +9 more
doaj   +1 more source

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