Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu +16 more
wiley +1 more source
Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala
Cell Reports, 2018 The basolateral amygdala (BLA) mediates associative learning for both fear and reward. Accumulating evidence supports the notion that different BLA projections distinctly alter motivated behavior, including projections to the nucleus accumbens (NAc ...
Anna Beyeler +6 more
doaj +1 more source
Long-term memory guides resource allocation in working memory
Scientific Reports, 2020 Working memory capacity is incredibly limited and thus it is important to use this resource wisely. Prior knowledge in long-term memory can aid in efficient encoding of information by allowing for the prioritization of novel stimuli over familiar ones ...
Allison L. Bruning +1 more
doaj +1 more source
The emergence of molecular systems neuroscience
Molecular Brain, 2022 Systems neuroscience is focused on how ensemble properties in the brain, such as the activity of neuronal circuits, gives rise to internal brain states and behavior.
Yang Shen +4 more
doaj +1 more source
Algebraic approach for subspace decomposition and clustering of neural activity
STAR Protocols, 2022 Summary: We developed an approach to decompose neuronal signals into disjoint components, corresponding to task- or event-based epochs. This protocol describes how to project behavioral templates onto a low-dimensional subspace of neuronal responses to ...
Elie M. Adam, Mriganka Sur
doaj +1 more source
Norepinephrine Involvement in the Intermittent Swim Stress-Induced Deficit in Spatial Learning and Memory [PDF]
, 2013 Learning and memory impairments are often caused by stress disorders including depression. The present study investigated the involvement of norepinephrine in the swim stress-induced deficits of spatial learning and memory.
Elgert, Emily
core +2 more sources
Women can bear a bigger burden: ante- and post-mortem evidence for reserve in the face of tau. [PDF]
, 2020 In this study, we aimed to assess whether women are able to withstand more tau before exhibiting verbal memory impairment. Using data from 121 amyloid-β-positive Alzheimer's Disease Neuroimaging Initiative participants, we fit a linear model with Rey ...
Alzheimer’s Disease Neuroimaging Initiative +6 more
core
Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams +14 more
wiley +1 more source
Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
Nature Communications, 2018 Structural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhanced ...
Adam C. Frank +10 more
doaj +1 more source
Memory, learning and language in autism spectrum disorder [PDF]
, 2018 Background and aims: The ‘dual-systems’ model of language acquisition has been used by Ullman and colleagues to explain patterns of strength and weakness in the language of higher-functioning people with autism spectrum disorder (ASD).
Bodison S. +9 more
core +2 more sources