Results 31 to 40 of about 139,691 (264)

Fast Learning with Weak Synaptic Plasticity [PDF]

The Journal of Neuroscience, 2015
New sensory stimuli can be learned with a single or a few presentations. Similarly, the responses of cortical neurons to a stimulus have been shown to increase reliably after just a few repetitions. Long-term memory is thought to be mediated by synaptic plasticity, butin vitroexperiments in cortical cells typically show very small changes in synaptic ...
Yger, Pierre, Stimberg, Marcel, Brette, Romain   +2 more
openaire   +2 more sources

Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures

NeuroImage: Clinical, 2018
No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim
M. Simó, A. Gurtubay-Antolin, L. Vaquero, J. Bruna, A. Rodríguez-Fornells   +4 more
doaj   +1 more source

Thalamic input to the lateral amygdala determines the temporal window of fear-memory association

Communications Biology
Memory consolidation is highly influenced by ongoing experiences. Here, we explore the temporal rules that determine whether events are cooperatively associated or competitively separated. We show that neutral events are associated with fearful events if
Natália Madeira, Inês Campelo, Rosalina Fonseca   +2 more
doaj   +1 more source

Area- and Energy-Efficient STDP Learning Algorithm for Spiking Neural Network SoC

IEEE Access, 2020
Recently, spiking neural networks have gained attention owing to their energy efficiency. All-to-all spike-time dependent plasticity is a popular learning algorithm for spiking neural networks because it is suitable for nondifferentiable spike event ...
Giseok Kim, Kiryong Kim, Sara Choi, Hyo Jung Jang, Seong-Ook Jung   +4 more
doaj   +1 more source

Meta-learning biologically plausible plasticity rules with random feedback pathways

Nature Communications, 2023
The biological plausibility of backpropagation and its relationship with synaptic plasticity remain open questions. The authors propose a meta-learning approach to discover interpretable plasticity rules to train neural networks under biological ...
Navid Shervani-Tabar, Robert Rosenbaum
doaj   +1 more source

Update on an Observational, Clinically Useful Gait Coordination Measure: The Gait Assessment and Intervention Tool (G.A.I.T.)

Brain Sciences, 2022
With discoveries of brain and spinal cord mechanisms that control gait, and disrupt gait coordination after disease or injury, and that respond to motor training for those with neurological disease or injury, there is greater ability to construct more ...
Janis J. Daly, Jessica P. McCabe, María Dolores Gor-García-Fogeda, Joan C. Nethery   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The role of alpha-rhythm states in perceptual learning: insights from experiments and computational models

Frontiers in Computational Neuroscience, 2014
During the past two decades growing evidence indicates that brain oscillations in the alpha band (~10 Hz) not only reflect an ‘idle’ state of cortical activity, but also take a more active role in the generation of complex cognitive functions.
Rodrigo eSigala, Rodrigo eSigala, Sebastian eHaufe, Sebastian eHaufe, Dipanjan eRoy, Dipanjan eRoy, Hubert R Dinse, Petra eRitter, Petra eRitter, Petra eRitter, Petra eRitter   +10 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source