Results 81 to 90 of about 65,366 (350)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

GeoGebra in Discovery Learning: Alternative Solutions for Understanding Mathematical Concepts

Journal of Mathematics Instruction, Social Research and Opinion
In learning, students are required to understand the concepts of problems and visualize the objects of mathematical learning discussions. However, in reality, students face difficulties in understanding and visualizing the objects discussed; learning ...
Putri Wardani, Machrani Adi Putri Siregar   +1 more
doaj   +1 more source

Effects of computer-supported collaboration script and incomplete concept maps on web design skills in an online design-based learning environment [PDF]

, 2012
Web design skills are an important component of media literacy. The aim of our study was to promote university students’ web design skills through online design-based learning (DBL).
El-Refai, Walid
core  

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Information technology as boundary object for transformational learning

, 2009
Collaborative work is considered as a way to improve productivity and value generation in construction. However, recent research demonstrates that socio-cognitive factors related to fragmentation of specialized knowledge may hinder team performance. New
Forgues, Daniel, Koskela, LJ, Lejeune, A, Koskela, Lauri, Lejeune, Albert, Forgues, D   +5 more
core  

Tools for Creating E-Learning: Learning Objects

, 2004
Learning objects are small units of instructionally sound content intended to teach a focused concept. Learning objects are developed to meet specific educational objectives.
Barker, Scott, Wright, Vivian H., Wright, Kenneth E., Winterstein, Andrew P.   +3 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Ontological Design of E-Learning Objects based on the Learning Object Metadata Standard in Organizational Repositories of Iranian Medical Sciences Universities [PDF]

بازیابی دانش و نظام‌های معنایی
IntroductionThe present research attempts to identify standard metadata elements for organizing learning objects in the organizational repositories of Iranian medical sciences universities based on the learning object metadata standard.
Leila Arabgari, Masoumeh Karbalee Agha Kamran, Zoya Abam, Atefeh Sharif   +3 more
doaj   +1 more source

Learning Effectiveness of Equilibrium Concept of Objects Through the Walking Stability Bipedal Robots [PDF]

, 2021
Afrizal Mayub, Fahmizal Fahmizal
openalex   +1 more source

From Material Objects to Social Objects : Researching the Material-Dialogic Spaces of Joint Attention in a School-based Makerspace [PDF]

, 2019
In this paper, we investigate the material-discursive spaces of joint attention between students and their teachers in a school-based makerspace. Drawing on sociocultural theorizing, Bakhtinian inspired notion of the “dialogic space”, and material ...
Kumpulainen, Kristiina, Kajamaa, Anu
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