Results 51 to 60 of about 664,687 (298)
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
International Journal of Educational Spectrum, 2019 In this study, it was aimed to examine the learning outcomes stated in the Turkish Language Course Curriculums of the 5th, 6th, 7th and 8th graders with a reference to narrative texts, and to describe and interpret the findings.
Duygu EROĞLU ÇOPUR
doaj +1 more source
Defining the value added of using Outcome Mapping in complex scenarios. Supporting real-time, results-based learning (OM ideas No. 9) [PDF]
, 2014 sponsorship: This report is published by the Outcome Mapping Learning Community, an open network governed by a group of voluntary ‘Stewards’, managed by the Overseas Development Institute and supported financially by the International Development ...
Van Ongevalle, Jan, Peels, Rafaël
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Using a Multiclass Machine Learning Model to Predict the Outcome of Acute Ischemic Stroke Requiring Reperfusion Therapy [PDF]
, 2021 Prediction of functional outcome in ischemic stroke patients is useful for clinical decisions. Previous studies mostly elaborate on the prediction of favorable outcomes. Miserable outcomes, which are usually defined as modified Rankin Scale (mRS) 5–
Chun-Hung Richard Lin +4 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
CITIZEN SCIENCE PROJECT'S CONTRIBUTION TO SCIENCE LEARNING OUTCOME: SYSTEMATIC LITERATURE REVIEW
EDUSAINS, 2023 The research on the contributions of Citizen Science (CS) at the school and university levels has primarily focused on the technical execution of projects undertaken by participants.
Ipin Aripin +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Module on Step-0 : how to prepare for OM intentional design [PDF]
, 2009 Existing manuals make a lot of implicit assumptions about processes and preparations that have taken place before actually applying the OM approach.
Roduner, Daniel, Hartmann, Olivia
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source