Results 101 to 110 of about 2,474,660 (311)

Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades

Leukemia, 2016
Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation ...
M. Adamiak, Ahmed Abdelbaset-Ismail, M. Suszyńska, A. Abdel-Latif, J. Ratajczak, M. Ratajczak   +5 more
semanticscholar   +1 more source

The lectin pathway of complement activation

, 2007
The complement system is an important immune system mechanism involved in both the recognition and elimination of invading pathogens. It is activated by three different pathways: The classical pathway, which relies on binding of C1, and results in the cleavage of C4 and C2 through activation of C1r and C1s; the alternative pathway that relies on the ...
openaire   +1 more source

Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime

Advanced Science, EarlyView.
A hollow nanomotor (PM‐HMSN/Arg) propelled by ultrasound‐triggered nitric oxide (NO) was developed. The nanomotor employs a “tethering‐relaxing‐drilling” mechanism to overcome biological barriers, enabling multimodal theranostics of cancer with deep penetration and extended lifetime.
Xue Xu, Jinxu Cao, Yan Mu, Hao Zhang, Ya‐Lei Wang, Mengzhen Chen, Yuce Li, Qian Hua   +7 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies

Scientific Reports
Increasing evidence points toward an essential role for complement activation in the pathogenesis of diabetic kidney disease (DKD). However, the precise molecular mechanisms remain unclear, and the pathway predominantly contributing to complement ...
Yang Yang, Ying Zhang, Yuan Li, Xinjin Zhou, Kazuho Honda, Dedong Kang, Muxi Wang, Jing-Hua Yang, Zongping Xia, Yuan Wei, Lu Liu, Ruimin Hu, Takashi Takaki, Guolan Xing   +13 more
doaj   +1 more source

An Apple Susceptibility‐Related LRR Receptor‐Like Kinase MdRLKT21 Activates Plant Immunity by Hijacking a Trans‐Kingdom Fungal microRNA‐Like RNA

Advanced Science, EarlyView.
The apple susceptibility‐related LRR‐RLK MdRLKT21 competitively binds to fungal sRNA effectors and subsequently activates defenses by salvaging the expression of MdRLKT1 and MdRLKT2 and thereby releasing the resistance protein MdRFP1. These findings provide new insights into the molecular mechanism by which plants counteract pathogen‐secreted sRNA ...
Mingliang Lei, Jian Zhang, Jie Wang, Chengyu Gao, Yanting He, Runze Tian, Hao Feng, Lili Huang   +7 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science, EarlyView.
This study presents a comprehensive data mining strategy for in‐depth extraction of overall and altered glycan features from structural and site‐specific glycoproteome data across various biomedical samples. The strategy enables the uncovery of four major altered glycan features associated with thymic involution and reveals their coordinated ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
wiley   +1 more source

Rationale for targeting complement in COVID‐19

EMBO Molecular Medicine, 2020
A novel coronavirus, SARS‐CoV‐2, has recently emerged in China and spread internationally, posing a health emergency to the global community. COVID‐19 caused by SARS‐CoV‐2 is associated with an acute respiratory illness that varies from mild to the life ...
Anastasia Polycarpou, Mark Howard, Conrad A Farrar, Roseanna Greenlaw, Giorgia Fanelli, Russell Wallis, Linda S Klavinskis, Steven Sacks   +7 more
doaj   +1 more source