Results 261 to 270 of about 2,474,660 (311)

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Unveiling the Evolutionary History of European Vipers and Their Venoms From a Multi‐Omic Approach

Molecular Ecology, EarlyView.
ABSTRACT Snake genomes attract significant attention from multiple disciplines, including medicine, drug bioprospection, and evolutionary biology. However, genomic research within the Viperidae family has mostly focused on the subfamily Crotalinae, while the true vipers (Viperinae) have largely been overlooked.
Adrián Talavera, Marc Palmada‐Flores, Fernando Martínez‐Freiría, Gabriel Mochales‐Riaño, Bernat Burriel‐Carranza, Maria Estarellas, Daniel Fernández‐Guiberteau, Álvaro Camina, Sylvain Ursenbacher, Judit Vörös, Bálint Halpern, Davinia Pla, Juan José Calvete, Alexander S. Mikheyev, Tomàs Marquès‐Bonet, Salvador Carranza   +15 more
wiley   +1 more source

The Evolutionary Dynamics of Genetic Mutational Load Throughout Tomato Domestication History

Molecular Ecology, EarlyView.
ABSTRACT Understanding the impact of domestication on deleterious mutations has fascinated evolutionary biologists and breeders alike. A ‘cost of domestication’ has been reported for some organisms through accumulation of gene disruptions or radical amino acid changes.
Hamid Razifard, Sofia Visa, Naama Menda, Lukas Mueller, Denise Tieman, Esther van der Knaap, Ana L. Caicedo   +6 more
wiley   +1 more source

The Lectin Pathway of Complement and Biocompatibility. [PDF]

Advances in Experimental Medicine and Biology, 2015
In modern health technologies the use of biomaterials in the form of stents, haemodialysis tubes, artificial implants, bypass circuits etc. is rapidly expanding. The exposure of synthetic, foreign surfaces to the blood and tissue of the host, calls for strict biocompatibility in respect to contact activation, the coagulation system and the complement ...
Estrid Hein, P. Garred
semanticscholar   +4 more sources

Ficolins and the lectin complement pathway [PDF]

Immunological Reviews, 2001
Summary:Ficolins, found in various tissues, are a group of proteins containing both a collagen‐like and a fibrinogen‐like domain. Recently, it was shown that ficolins present in serum are lectins with a common binding specificity for N‐acetylglucosamine (GlcNAc). The fibrinogen‐like domain is responsible for the carbohydrate binding.
Teizo Fujita, Misao Matsushita
openaire   +2 more sources

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Inhibition of the Lectin Pathway of the Complement System as a Novel Approach in the Management of IgA Vasculitis-Associated Nephritis

Nephron, 2020
IgA vasculitis can present as a glomerulonephritis histologically indistinguishable from IgA nephropathy (IgAN). In IgAN, the alternative and lectin pathways mediate glomerular injury and contribute to kidney function decline. Narsoplimab is a monoclonal
H. Selvaskandan, Chee Kay Cheung, J. Dormer, David H. Wimbury, Maria Martinez, Gang Xu, J. Barratt   +6 more
semanticscholar   +1 more source

Assays for the Mannan‐Binding Lectin Pathway

Current Protocols in Immunology, 2003
AbstractThis unit contains protocols that can be used to measure mannan‐binding lectin (MBL) levels and MBL pathway activity in human plasma or serum. Using a modification of the conventional ELISA, the detection reagent used in the methods described (e.g., an antibody or streptavidin) is labeled with Eu3+ instead of an enzyme.
Gadjeva, Mihaela, Thiel, Steffen, Jensenius, Jens Christian   +2 more
openaire   +3 more sources

Activation of the lectin complement pathway by ficolins

International Immunopharmacology, 2001
Mannose-binding lectin (MBL), a serum lectin specific for mannose or N-acetylglucosamine (GlcNAc), which contains both a collagen-like domain and a carbohydrate-recognition domain (CRD), plays a role in innate immunity by acting as an opsonin and activating complement in association with MBL-associated serine protease (MASP) via the lectin pathway ...
Naotaka Hamasaki, Teizo Fujita, Misao Matsushita, Yuichi Endo   +3 more
openaire   +3 more sources

The Lectin Pathway of the Complement System

Microbiology and Immunology, 1996
One of the activities of animal lectins is the elimination of pathogens from a host. Serum mannose (or mannan)-binding protein (MBP) (25), in this capacity, recognizes mannose or N-acetylglucosamine on the surfaces of microorganisms. MBP is a member of the 'collectin' family (6), a group of C-type Ca2+-denendent animal lectins (3) which includes two ...
openaire   +3 more sources