Results 51 to 60 of about 2,513,226 (377)
Signal Transduction and Targeted Therapy, 2022 Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses, but the underlying mechanism remains unclear. In this study, the N proteins of highly pathogenic human coronaviruses, including severe
Ting Gao +31 more
semanticscholar +1 more source
PLoS Pathogens, 2022 The complement system is a first-line innate host immune defence against invading pathogens. It is activated via three pathways, termed Classical, Lectin and Alternative, which are mediated by antibodies, carbohydrate arrays or microbial liposaccharides,
Carolina De Marco Verissimo +5 more
doaj +1 more source
Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]
, 1998 The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core +2 more sources
Innate immunity and neuroinflammation [PDF]
, 2013 Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core +3 more sources
Immunity & Ageing, 2020 Background There is increasing recognition of the significance of chronic, low-level inflammation in older adults, or “inflammaging.” Innate immune responses and host-bacterial interactions are recognized as key factors in inflammaging.
David C. LaFon +4 more
doaj +1 more source
Detection of Sugar-Lectin Interactions by Multivalent Dendritic Sugar Functionalized Single-Walled Carbon Nanotubes [PDF]
Appl. Phys. Lett. 101, 053701 (2012), 2012 We show that single walled carbon nanotubes (SWNT) decorated with sugar functionalized poly (propyl ether imine) (PETIM) dendrimer is a very sensitive platform to quantitatively detect carbohydrate recognizing proteins, namely, lectins. The changes in electrical conductivity of SWNT in field effect transistor device due to carbohydrate - protein ...
arxiv +1 more source
Role of the lectin complement pathway in kidney transplantation [PDF]
Immunobiology, 2016 In the last 15 years two major advances in the role of complement in the kidney transplant have come about. The first is that ischaemia reperfusion injury and its profound effect on transplant outcome is dependent on the terminal product of complement activation, C5b-9. The second key observation relates to the function of the small biologically active
Farrar, Conrad A. +2 more
openaire +6 more sources
Engineering novel complement activity into a pulmonary surfactant protein [PDF]
, 2010 Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Anthony H. Keeble +38 more
core +2 more sources
Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway. [PDF]
PLoS Neglected Tropical Diseases, 2014 Scabies is an infectious skin disease caused by the mite Sarcoptes scabiei and has been classified as one of the six most prevalent epidermal parasitic skin diseases infecting populations living in poverty by the World Health Organisation.
Simone L Reynolds +7 more
doaj +1 more source
Studies Into β-Glucan Recognition in Fish Suggests a Key Role for the C-Type Lectin Pathway. [PDF]
Front Immunol, 2019 Immune-modulatory effects of β-glucans are generally considered beneficial to fish health. Despite the frequent application of β-glucans in aquaculture practice, the exact receptors and downstream signalling remains to be described for fish.
Petit J +5 more
europepmc +2 more sources