Results 51 to 60 of about 2,474,660 (311)
PLoS Pathogens, 2022 The complement system is a first-line innate host immune defence against invading pathogens. It is activated via three pathways, termed Classical, Lectin and Alternative, which are mediated by antibodies, carbohydrate arrays or microbial liposaccharides,
Carolina De Marco Verissimo +5 more
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Immunity & Ageing, 2020 Background There is increasing recognition of the significance of chronic, low-level inflammation in older adults, or “inflammaging.” Innate immune responses and host-bacterial interactions are recognized as key factors in inflammaging.
David C. LaFon +4 more
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Role of the lectin complement pathway in kidney transplantation [PDF]
Immunobiology, 2016 In the last 15 years two major advances in the role of complement in the kidney transplant have come about. The first is that ischaemia reperfusion injury and its profound effect on transplant outcome is dependent on the terminal product of complement activation, C5b-9. The second key observation relates to the function of the small biologically active
Farrar, Conrad A. +2 more
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Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway. [PDF]
PLoS Neglected Tropical Diseases, 2014 Scabies is an infectious skin disease caused by the mite Sarcoptes scabiei and has been classified as one of the six most prevalent epidermal parasitic skin diseases infecting populations living in poverty by the World Health Organisation.
Simone L Reynolds +7 more
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Association Study of Mannose-Binding Lectin Levels and Genetic Variants in Lectin Pathway Proteins with Susceptibility to Age-Related Macular Degeneration: A Case-Control Study. [PDF]
PLoS ONE, 2015 In age-related macular degeneration (AMD) the complement system is thought to be activated by chronic oxidative damage with genetic variants identified in the alternative pathway as susceptibility factors.
Michael Osthoff +6 more
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The complement lectin pathway after cardiac arrest [PDF]
Scandinavian Journal of Immunology, 2018 AbstractThe lectin pathway (LP) of the complement system may initiate inflammatory reactions when body tissue is altered. We aimed to investigate the levels of the LP proteins in out‐of‐hospital cardiac arrest patients, and to compare these with healthy individuals.
S. F. Haugaard +5 more
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The Complement System of Agnathans
Frontiers in Immunology, 2018 Agnathans (lamprey and hagfish) are a group of primitive jawless fish. Jawed vertebrates possess adaptive immunity including immunoglobulins, while agnathans lack immunoglobulins but have alternative adaptive immunity in which variable lymphocyte ...
Misao Matsushita
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Isolation and characterization of novel primary cells from the human distal outflow pathway
Scientific Reports, 2021 Ocular hypertension occurs due to increased resistance to aqueous humor removal through the conventional outflow pathway. Unlike the proximal region of the conventional outflow pathway, the distal region has not been well studied, mostly due to lack of ...
Uttio Roy Chowdhury +4 more
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Journal of Innate Immunity, 2021 Activation of the complement system is mediated by the interaction between pathogens and pattern recognition molecules (PRMs); mannose-binding lectin (MBL), ficolins, and collectin-10/-11 from the lectin pathway and C1q from the classical pathway. Lectin
Anne Rosbjerg +3 more
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Enhancement of lectin pathway haemolysis by immunoglobulins
Clinical and Experimental Immunology, 1999 SUMMARYWe recently reported that indicator sheep erythrocytes (E) coated with mannan and sensitized with mannan-binding lectin (MBL) (E-M-MBL) are lysed by human serum in the absence of calcium via the lectin pathway of complement activation by a process which requires alternative pathway amplification and is associated with increased binding of and ...
Henry Gewurz +4 more
openaire +3 more sources