Results 151 to 160 of about 30,035 (192)

Emerging trends in the management of non‐obstructive azoospermia

open access: yesUroPrecision, EarlyView.
Abstract Ten percent of infertile males have azoospermia, classified into obstructive and nonobstructive types, which require specific medical or surgical treatments. In nonobstructive azoospermia, advancements in microsurgery allow for effective sperm retrieval in about half of cases.
Mina Saad   +4 more
wiley   +1 more source

Glycopattern comparison of sperm and exosomes from conventional in vitro fertilization and rescue intracytoplasmic sperm injection: Enhancing sperm motility through exosome‐mediated glycan modulation

open access: yesVIEW, EarlyView.
Infertility is a global concern, with male factors contributing to nearly half of cases. This study compared glycopatterns of sperm and sperm‐derived exosomes from conventional IVF and rescue ICSI (RICSI) patients, revealing key differences in glycan expression.
Muhammad Anas Ramzan   +10 more
wiley   +1 more source

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

open access: yesVIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source

Immunosenescence Profile Is Associated With Increased Susceptibility to Severe COVID‐19

open access: yesAging Cell, EarlyView.
(A) A previous immunosenescence profile in individuals infected with SARS‐CoV2 creates a permissive environment for progression to severe COVID‐19: higher inflammaging, accumulation of exhausted/senescent T cells, an oligoclonal B‐cell repertoire, and accelerated epigenetic age.
Lucas Haniel A. Ventura   +40 more
wiley   +1 more source

Age and Sex Effects on Blood Retrotransposable Element Expression Levels: Findings From the Population‐Based Rhineland Study

open access: yesAging Cell, EarlyView.
Retrotransposable element (RTE) expression increases with chronological and biological age and is negatively associated with heterochromatin regulators. Moreover, RTE expression shows sex‐specific differences, with higher levels in men and enrichment for immune‐related pathways.
Valentina Talevi   +6 more
wiley   +1 more source

Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8+ T Cells Responding to Coronavirus Infection

open access: yesAging Cell, EarlyView.
In a MHV infection model with age‐associated increased mortality, we demonstrate that aging impairs, instead of promoting, the terminal differentiation program of virus‐specific CD8+ T cells through downregulating key transcriptional regulators of terminal differentiation.
Ziang Zhu   +8 more
wiley   +1 more source

Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats

open access: yesAging Cell, EarlyView.
Cardiorespiratory fitness (CRF) is not associated with epigenetic clocks, including newly developed ones. On the other hand, CRF is associated with global methylation profiles and promoter methylation in organ‐specific and organ‐common manner. ABSTRACT Epigenetic drift, which is gradual age‐related changes in DNA methylation patterns, plays a ...
Takuji Kawamura   +15 more
wiley   +1 more source

Vaccine‐Induced Anti‐IgE Antibodies Neutralize Free IgE but Fail to Bind and Activate Mast Cell‐Displayed IgE

open access: yesAllergy, EarlyView.
We investigated the mechanisms by which a previously established VLP‐based anti‐IgE vaccine protects against allergic anaphylaxis. We show that passively administered vaccine‐induced IgGs into allergic mice protects them from anaphylaxis without side effects.
Zahra Gharailoo   +3 more
wiley   +1 more source

Gastrointestinal Barrier Disruption in Post‐COVID Syndrome Fatigue Patients

open access: yesAllergy, EarlyView.
Gastrointestinal (GI) barrier disruption in the context of SARS‐CoV‐2 infection is associated with the development of Post‐COVID Syndrome (PCS) Fatigue. Pre‐existing GI complaints may predispose to fatigue development. Monitoring GI symptoms and markers before, during, and after SARS‐CoV‐2 infection is crucial for identifying predictive clinical ...
Johanna Rohrhofer   +8 more
wiley   +1 more source

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