Results 151 to 160 of about 1,772,176 (315)
Influenza and memory T cells : how to awake the force [PDF]
, 2016 Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen +12 more
core +3 more sources
Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex
Advanced Science, EarlyView.The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano +11 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2016 Human CARD9 deficiency is an autosomal recessive primary immunodeficiency disorder caused by biallelic mutations in the gene CARD9, which encodes a signaling protein that is found downstream of many C-type lectin receptors (CLRs).
Rebecca A. Drummond, Michail S. Lionakis
doaj +1 more source
Signaling C-type lectin receptors in antimycobacterial immunity
PLOS Pathogens, 2017 The mammalian innate immune system is composed of phagocytes such as macrophages and dendritic cells that serve as the first line of defense against microbial infections. These cells express various pattern recognition receptors (PRRs) that recognize specific pathogen-associated molecular patterns (PAMPs) on the surface of or inside microorganisms [1].
Mohlopheni J. Marakalala, Hlumani Ndlovu
openaire +6 more sources
Fermented mistletoe extract as a multimodal antitumoral agent in gliomas [PDF]
, 2012 In Europe, commercially available extracts from the white-berry mistletoe (Viscum album L.) are widely used as a complementary cancer therapy. Mistletoe lectins have been identified as main active components and exhibit cytotoxic effects as well as ...
Harter, Patrick Nikolaus +4 more
core +2 more sources
Aggregate, EarlyView.To overcome poor molecular recognition in dilute solutions of tetraphenylethylene‐embedded cyclo[6]arenes, three macrocycles with functionalized cavities featuring diazine groups as endo‐binding sites are synthesized. Their recognition affinity continuously improves with increasing hydrogen‐bond acceptance of diazine groups.
Nan Pan +6 more
wiley +1 more source
Tissue‐Resident Myeloid and Histiocytic Cells in Health and Disease: Novel Emerging Concepts
American Journal of Hematology, EarlyView.ABSTRACT Although all myeloid cells are considered to derive from hematopoietic stem cells, the cells in each myeloid lineage are heterogeneous populations, and their distribution and functions vary, depending on underlying physiologic and pathologic processes, age, sex, and genetic and epigenetic signatures.
Peter Valent +27 more
wiley +1 more source
Nature Communications, 2019 Dengue virus (DENV) promotes leukocyte-platelet interactions that contribute to pathogenesis. Here, the authors report a role for C-type lectins CLEC2 and CLEC5A in platelet activation and NET formation and show that blockade of CLEC5A and TLR2 ...
Pei-Shan Sung +2 more
doaj +1 more source
Biomolecules, 2015 Leguminous lectins have a conserved carbohydrate recognition site comprising four loops (A–D). Here, we randomly mutated the sequence and length of loops C and D of peanut agglutinin (PNA) and expressed the proteins on the surface of mouse green ...
Keisuke Soga +8 more
doaj +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD.
Zuqing Nie +9 more
wiley +1 more source