Results 11 to 20 of about 30,035 (192)

How C-type lectins detect pathogens

Cellular Microbiology, 2005
Glycosylation of proteins has proven extremely important in a variety of cellular processes, including enzyme trafficking, tissue homing and immune functions. In the past decade, increasing interest in carbohydrate-mediated mechanisms has led to the identification of novel carbohydrate-recognizing receptors expressed on cells of the immune system ...
Cambi, A., Koopman, M., Figdor, C.G.
openaire   +5 more sources

C-type lectins in immunity and homeostasis

Nature Reviews Immunology, 2018
The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands and that regulate a diverse range of physiological functions. Most research attention has focused on the ability of C-type lectins to function in innate and adaptive antimicrobial immune responses, but these proteins are increasingly being recognized to have a
Brown, Gordon D, Willment, Janet A, Whitehead, Lauren   +2 more
openaire   +5 more sources

Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins [PDF]

, 2018
Intestinal mucins trigger immune responses upon recognition by dendritic cells via protein–carbohydrate interactions. We used a combination of structural, biochemical, biophysical, and cell-based approaches to decipher the specificity of the interaction ...
Gunning, A. Patrick, Juge, Nathalie, Kavanaugh, Devon W., Kawasaki, Norihito, Latousakis, Dimitrios, Leclaire, Charlotte, Lecointe, Karine, Mackenzie, Donald A., Tribolo, Sandra, Wittmann, Alexandra   +9 more
core   +1 more source

Integrative analysis workflow for the structural and functional classification of C-type lectins [PDF]

, 2011
Background It is important to understand the roles of C-type lectins in the immune system due to their ubiquity and diverse range of functions in animal cells.
Koh, Geoffrey, Lam, Kong-Peng, Lee, Dong-Yup, Low, Ariana, Ng, Say Kong, Poh, Daren, Vagenende, Vincent, Wong, Victor Vai Tak, Yao, Yujian   +8 more
core   +3 more sources

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Ahmed, Bee K. Tan, Botto, Bouyain, Caparros, Carlow, Ceriello, Chaipan, Daniel A. Mitchell, Daniel Zehnder, Devaraj, Elizabeth J. Soilleux, Feinberg, Fernandez-Real, Geijtenbeek, Geijtenbeek, Geijtenbeek, Ghanim, Gringhuis, Guo, Harpal S. Randeva, Held, Hendrik Lehnert, Holman, Ip, Krutzik, Lee, Lillegard, Mitchell, Moller-Kristensen, Nauta, Paidassi, Paul Townsend, Permana, Pohlmann, Reading, Rebecca Ilyas, Robert B. Sim, Russell Wallis, Savill, Schilder, Seelen, Soilleux, Strong, Stuart, Turner, Turner, UKPDS, Wallis, Walport, Walport, Weis, Weis, Worthley, Zeyda   +54 more
core   +1 more source

A novel mechanism for binding of galactose-terminated glycans by the C-type carbohydrate recognition domain in blood dendritic cell antigen 2 [PDF]

, 2015
Blood dendritic cell antigen 2 (BDCA-2; also designated CLEC4C or CD303) is uniquely expressed on plasmacytoid dendritic cells. Stimulation of BDCA-2 with antibodies leads to an anti-inflammatory response in these cells, but the natural ligands for the ...
Drickamer, K, Dungarwalla, T, Feinberg, H, Jégouzo, SAF, Taylor, ME, Weis, WI   +5 more
core   +1 more source

Towards defining the role of glycans as hardware in information storage and transfer: Basic principles, experimental approaches and recent progress [PDF]

, 2001
The term `code' in biological information transfer appears to be tightly and hitherto exclusively connected with the genetic code based on nucleotides and translated into functional activities via proteins.
Gabius, Hans-Joachim, Jiménez-Barbero, J., Kaltner, H., Lieth, Claus-Wilhelm von der, Romero, A., Siebert, H.-C., Solís, Dolores   +6 more
core   +1 more source

Animal lectins as cell adhesion molecules [PDF]

, 1998
Protein-carbohydrate interaction is exploited in cell adhesion mechanisms besides the recognition of peptide motifs. The sugar code thus significantly contributes to the intriguing specificity of cellular selection of binding partners.
Kaltner, H., Stierstorfer, B.
core   +1 more source

Crystal structure of the GalNAc/Gal-specific agglutinin from the phytopathogenic ascomycete Sclerotinia sclerotiorum reveals novel adaptation of a beta-trefoil domain [PDF]

, 2010
International audienceA lectin from the phytopathogenic ascomycete Sclerotinia sclerotiorum that shares only weak sequence similarity with characterized fungal lectins has recently been identified. S.
Bourne, Yves, Peumans, Willy J, Roig-Zamboni, Veronique, Rouge, Pierre, Sulzenbacher, Gerlind, Van Damme, Els   +5 more
core   +2 more sources

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources