Results 11 to 20 of about 1,777,510 (315)
Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins [PDF]
The FASEB Journal, 2018 Intestinal mucins trigger immune responses upon recognition by dendritic cells via protein–carbohydrate interactions. We used a combination of structural, biochemical, biophysical, and cell‐based approaches to decipher the specificity of the interaction ...
C. Leclaire +9 more
semanticscholar +3 more sources
C-type lectins facilitate tumor metastasis
Oncology Letters, 2016 Metastasis, a life-threatening complication of cancer, leads to the majority of cases of cancer-associated mortality. Unfortunately, the underlying molecular and cellular mechanisms of cancer metastasis remain to be fully elucidated. C-type lectins are a
Dongbing Ding +4 more
semanticscholar +4 more sources
Transcriptome analyses to investigate symbiotic relationships between marine protists. [PDF]
Frontiers in Microbiology, 2015 Rhizaria are an important component of oceanic plankton communities worldwide. A number of species harbour eukaryotic microalgal symbionts, which are horizontally acquired in the environment at each generation.
Sergio eBalzano +8 more
doaj +6 more sources
Parasitic Infections: A Role for C-Type Lectins Receptors
BioMed Research International, 2013 Antigen-presenting cells (APCs) sense the microenvironment through several types of receptors that recognize pathogen-associated molecular patterns. In particular, C-type lectins receptors (CLRs), which are expressed by distinct subsets of dendritic ...
Alicia Vázquez-Mendoza +2 more
semanticscholar +4 more sources
C-type lectins in immunity: recent developments
Current Opinion in Immunology, 2015 C-type lectin receptors (CLRs) comprise a large superfamily of proteins, which recognise a diverse range of ligands, and are defined by the presence of at least one C-type lectin-like domain (CTLD). Of particular interest are the single extracellular CTLD-containing receptors of the 'Dectin-1' and 'Dectin-2' clusters, which associate with signalling ...
I. Dambuza, Gordon D. Brown
semanticscholar +5 more sources
C-type lectins in HIV-1 infection [PDF]
Retrovirology, 2011 Adaptive immune responses by dendritic cells (DCs) are controlled by pattern recognition receptors such as Toll-like receptors (TLRs) and C-type lectins. C-type lectins interact with carbohydrate structures on pathogens. Upon pathogen binding, C-type lectins trigger signaling pathways that induce specific cytokines to dictate T cell polarization. Thus,
Geijtenbeek Teunis BH
doaj +3 more sources
C-Type Lectin Receptors in Asthma [PDF]
Frontiers in Immunology, 2018 Asthma is a heterogeneous disease that affects approximately 300 million people worldwide, largely in developed countries. The etiology of the disease is poorly understood, but is likely to involve specific innate and adaptive responses to inhaled microbial components that are found in allergens.
Gordon D. Brown +5 more
openaire +5 more sources
Marine Drugs, 2023 C-type lectins belong to a widely conserved family of lectins characterized in Metazoa. They show important functional diversity and immune implications, mainly as pathogen recognition receptors.
Amaro Saco +3 more
doaj +1 more source
How C-type lectins detect pathogens [PDF]
Cellular Microbiology, 2005 Glycosylation of proteins has proven extremely important in a variety of cellular processes, including enzyme trafficking, tissue homing and immune functions. In the past decade, increasing interest in carbohydrate-mediated mechanisms has led to the identification of novel carbohydrate-recognizing receptors expressed on cells of the immune system ...
Cambi, A., Koopman, M., Figdor, C.G.
openaire +4 more sources
Molecular Recognition in C‐Type Lectins: The Cases of DC‐SIGN, Langerin, MGL, and L‐Sectin
ChemBioChem, 2020 Carbohydrates play a pivotal role in intercellular communication processes. In particular, glycan antigens are key for sustaining homeostasis, helping leukocytes to distinguish damaged tissues and invading pathogens from healthy tissues.
Pablo Valverde +4 more
semanticscholar +1 more source