Results 61 to 70 of about 58,592 (288)

The Dynamic Landscape of Novel Psychoactive Substance (NPS) Use in Ireland: Results from an Expert Consultation [PDF]

In Ireland, legislators encountered a new phenomenon in 2005 onwards with the advent of ‘legal highs’ sold in headshops. Use of ‘legal highs’ containing herbal and synthetic new psychoactive substances (NPS) was not confined to problematic drug users ...
A Lavorgna, BP Smyth, C Giese, C Uhoegbu, E El-Higaya, European Monitoring Centre for Drugs and Drug Addiction, F Caudevilla, G Ryall, Health Research Board. Irish National Focal Point to the European Monitoring Centre for Drugs and Drug Addiction, HF Hsieh, J Tully, JA Lewnard, JG1 Amsterdam van, K McElrath, L Orsolini, Marie Claire Van Hout, MC Van Hout, MC Van Hout, MC Van Hout, MC Van Hout, MC Van Hout, MC Van Hout, MC Van Hout, P Kavanagh, PM O’Byrne, S O’Domhnail, V Gilbart   +26 more
core   +1 more source

Quantifying the Temperature of Maggot Masses and its Relationship to Decomposition [PDF]

, 2014
Numerous Calliphoridae species have been observed to form larval aggregations during the feeding stage of development, resulting in localized increases in temperature.
Amendt, Ames, Anderson, Anderson, Arnaldos, Benecke, Byrd, Byrd, Byrd, Byrd, Byrd, Campobasso, Campobasso, Catts, Charabidze, Davidson, Donovan, Gallagher, Goodbrod, Grassberger, Grassberger, Grassberger, Grassberger, Haskell, Hobson, Huckesfeld, Huntington, Introna, Ireland, Joy, Kashyap, Marhenko, Nabity, Niederegger, R Development Core Team, Richards, Rivers, Rodriguez, Saunders, Schoofs, Shean, Slone, Tarone, Vanin, Wall, Wall   +45 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Chest pain, troponin rise, and ST-elevation in an adolescent boy following the use of the synthetic cannabis product K2

Annals of Pediatric Cardiology, 2016
"Legal highs" such as K2, which typically contain synthetic cannabinoids, are increasingly popular with adolescents around the world. We have limited knowledge concerning their toxicity or adverse effects and their mechanism of action is poorly ...
Sona Zaleta, Prashant Kumar, Sarah Miller   +2 more
doaj   +1 more source

A critical analysis of New Zealand's Psychoactive Substances Act 2013 and its implementation process : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Public Health at Massey University, Albany, New Zealand [PDF]

, 2017
Listed in 2017 Dean's List of Exceptional ThesesIntroduction: In July 2013, the New Zealand Parliament passed the Psychoactive Substances Act (PSA), the world’s first law to regulate the availability of new psychoactive substances (NPS, “legal highs ...
Rychert, Marta
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Impact of the Pandemic on Selected Aspects of Health-Promoting Attitudes in 2020–2021: A Cross-Sectional Study

Frontiers in Public Health, 2022
IntroductionIn the face of the COVID-19 pandemic, people began to change both their health-promoting and anti-health behaviors.Aim of the PaperTo assess the impact of the pandemic on selected health-promoting attitudes.MethodsThe cross-sectional study ...
Agnieszka Kułak-Bejda, Grzegorz Bejda, Wojciech Kułak, Andrzej Guzowski, Joanna Fiłon, Cecylia Łukaszuk, Mateusz Cybulski, Napoleon Waszkiewicz, Elzbieta Krajewska-Kułak   +8 more
doaj   +1 more source

Recreational use, analysis and toxicity of tryptamines [PDF]

, 2015
The definition New psychoactive substances (NPS) refers to emerging drugs whose chemical structures are similar to other psychoactive compounds but not identical, representing a "legal" alternative to internationally controlled drugs.
Mannocchi, Giulio, Pantano, Flaminia, Romolo, Francesco Saverio, Tittarelli, Roberta   +3 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Same-Sex Marriage and Other Moral Taboos: Cultural Acceptances, Change in American Public Opinion and the Evidence from the Opinion Polls [PDF]

, 2017
This article analyzes the evolution of gay and lesbian rights and same-sex marriage in American public opinion. It describes how Obergefell v. Hodges, state-level decisions and the public opinion trends can be considered as the outcome of a grassroots ...
Morini, Marco
core   +4 more sources