Results 91 to 100 of about 35,037 (252)

Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites. [PDF]

, 2011
Our work on targeting redox equilibria of malarial parasites propagating in red blood cells has led to the selection of six 1,4-naphthoquinones, which are active at nanomolar concentrations against the human pathogen Plasmodium falciparum in culture and ...
Bauer, Holger, Brückner, Margit, Davioud-Charvet, Elisabeth, Deregnaucourt, Christiane, Jannack, Beate, Johann, Laure, Lanfranchi, Don Antoine, Lanzer, Michael, Müller, Tobias, Sanchez, Cecilia, Schirmer, R Heiner, Schrével, Joseph, Yardley, Vanessa   +12 more
core   +2 more sources

Complete Resolution of Cutaneous Leishmaniasis With a Novel Topical Combination Therapy: A Case Series

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Cutaneous leishmaniasis (CL) remains a therapeutic challenge in endemic regions, with 600,000–1 million new cases annually facing limited treatment options. We present a case series evaluating an innovative topical combination therapy for acute‐phase CL in Shiraz, Iran.
Hoda Haghshenas, Aref Ghanaatpisheh, Mohammad Darayesh, Elaheh Entezar Almahdi   +3 more
wiley   +1 more source

Field ecology of sylvatic Rhodnius populations (Heteroptera, Triatominae): risk factors for palm tree infestation in western Ecuador. [PDF]

, 2005
Most Rhodnius species (Triatominae) are primarily associated with palm trees. They maintain enzootic Trypanosoma cruzi transmission and are responsible for human infection (causing Chagas disease) through the Neotropics. Assessing whether individual palm
Ho, A. Y. Q., Hogg, David W., Martig, M., Ness, M., Pinsonneault, Marc H., Rix, H.-W.   +5 more
core   +4 more sources

When Hepatitis Masks Visceral Leishmaniasis: A Case of Secondary HLH in a Low‐Endemic Region

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Visceral leishmaniasis (VL)–associated hemophagocytic lymphohistiocytosis (HLH) is a rare but life‐threatening hyperinflammatory syndrome. Diagnosis is often challenging due to overlapping clinical features, especially in low‐endemic regions, where VL is not initially suspected.
Chernet T. Mengistie, Biruk T. Mengistie, Temesgen H. Gebremeskel, Thomas M. Muluneh, Rediet G. Kebede   +4 more
wiley   +1 more source

A neglected disease of humans: a new focus of visceral leishmaniasis in Bakool, Somalia. [PDF]

, 2008
Visceral leishmaniasis (VL) was observed in children in Bakool region, Somalia, an area where VL has not been reported before. We describe the extent of the problem in this war- and famine-stricken area.
Boelaert, M, Dujardin, J C, Jacquet, D, Marlet, M V L, Quispe, K W, Wuillaume, F   +5 more
core   +1 more source

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]

, 2017
Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M., Alzahrani, Khalid J.H., Barrett, Michael P., Creek, Darren J., De Koning, Harry P., Eze, Anthonius A., Looi, Wan Limm, Tagoe, Daniel N.A.   +7 more
core   +2 more sources

Intra- and interspecific polymorphisms ofLeishmania donovani andL. tropica minicircle DNA [PDF]

, 1994
A pair of degenerate polymerase chain reaction (PCR) primers (LEI-1, TCG GAT CC[C,T] [G,C]TG GGT AGG GGC GT; LEI-2, ACG GAT CC[G,C] [G,C][A,C]C TAT [A,T]TT ACA CC) defining a 0.15-kb segment ofLeishmania minicircle DNA was constructed.
AJ Magill, DC Barker, DF Smith, DG Higgins, F Sanger, GZ Kidane, H. Rinder, JM Blackwell, K Stuart, MHL Bruijn de, P. Dobner, R Sommer, RD Kreutzer, S Lee, T Laskay, T. L�scher, WO Rogers   +16 more
core   +1 more source

Sorbitol‐Induced Synchronisation of Babesia duncani and Assessment of Linoleic Acid Effect on Parasite‐Derived Vesicles

Parasite Immunology, Volume 47, Issue 10, October 2025.
ABSTRACT Human babesiosis is an emerging infectious disease caused by a bloodborne single‐celled parasite belonging to the genus Babesia. Cases of human babesiosis are commonly reported in the United States, Western Europe and Asia. In the United States, the two major causative agents are Babesia microti and Babesia duncani.
Simone Haak, Dong Chen, Ronald Soriano, Jonas Gunnarsson, Jose Thekkiniath   +4 more
wiley   +1 more source

Leishmania donovani populations in Eastern Sudan: temporal structuring and a link between human and canine transmission. [PDF]

, 2014
BACKGROUND: Visceral leishmaniasis (VL), caused by the members of the Leishmania donovani complex, has been responsible for devastating VL epidemics in the Sudan.
Baleela, Rania, Fitzpatrick, Sinead, Kuhls, Katrin, Llewellyn, Martin S, Mauricio, Isabel L, Miles, Michael A, Schönian, Gabriele   +6 more
core   +3 more sources

Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry

ChemMedChem, Volume 20, Issue 18, September 25, 2025.
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali, Samet Poyraz, Samet Belveren, Senanur Taş, Mehmet Ali Tamer, Naciye Yaktubay Döndaş, H. Ali Döndaş, Jose Miguel Sansano   +7 more
wiley   +1 more source