Results 91 to 100 of about 29,719 (208)

Structure of Plasmodium vivaxN‐myristoyltransferase with inhibitor IMP‐1088: exploring an NMT inhibitor for antimalarial therapy

Acta Crystallographica Section F, Volume 81, Issue 1, Page 1-10, January 2025.
The 1.8 Å resolution ternary structure of P. vivaxN‐myristoyltransferase in complex with IMP‐1088 and myristoyl‐CoA is presented. IMP‐1088 is an N‐myristoyltransferase inhibitor from a family of inhibitors that are under investigation as antimalarials.Plasmodium vivax, a significant contributor to global malaria cases, poses an escalating health burden
Alex Mendez, Cydni Bolling, Shane Taylor, Stanley Makumire, Bart Staker, Alexandra Reers, Brad Hammerson, Stephen J. Mayclin, Jan Abendroth, Donald D. Lorimer, Thomas E. Edwards, Edward W. Tate, Sandhya Subramanian, Andrew S. Bell, Peter J. Myler, Oluwatoyin A. Asojo, Graham Chakafana   +16 more
wiley   +1 more source

Uniting mathematics and biology for control of visceral leishmaniasis [PDF]

, 2015
The neglected tropical disease (NTD) visceral leishmaniasis (VL) has been targeted by the WHO for elimination as a public health problem on the Indian subcontinent by 2017 or earlier.
Adams, ER, De Vlas, SJ, Hollingsworth, TD, Le Rutte, EA, Medley, GF, Rock, KS   +5 more
core   +2 more sources

L-Asparaginase of Leishmania donovani: Metabolic target and its role in Amphotericin B resistance

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Emergence of Amphotericin B (AmB) resistant Leishmania donovani has posed major therapeutic challenge against the parasite. Consequently, combination therapy aimed at multiple molecular targets, based on proteome wise network analysis has been ...
Jasdeep Singh, Mohd Imran Khan, Shiv Pratap Singh Yadav, Ankit Srivastava, Kislay K. Sinha, Ashish, Pradeep Das, Bishwajit Kundu   +7 more
doaj  

Fatal Outcome of Membranoproliferative Glomerulonephritis in a Patient With Hidden Visceral Leishmaniasis

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Background: Visceral leishmaniasis (VL) is a systemic parasitic disease with diverse clinical manifestations, primarily affecting the spleen, liver, and bone marrow. While renal involvement in VL is well documented, it is often mild and resolves with effective treatment.
Ali Mansoursamaei, Maryam Valikhani, Hoofar Rafiee, Mohamed A. Dkhil   +3 more
wiley   +1 more source

Noncovalent complexation of amphotericin-B with Poly(α-glutamic acid).

, 2013
A noncovalent complex of amphotericin B (AmB) and poly(α-glutamic acid) (PGA) was prepared to develop a safe and stable formulation for the treatment of leishmaniasis. The loading of AmB in the complex was in the range of ∼20-50%.
Brocchini, Stephen, Croft, Simon L, Les, Karolina A, Mohamed-Ahmed, Abeer HA, Seifert, Karin   +4 more
core   +1 more source

Rapid Detection of Leishmania infantum Infection in Dogs: Comparative Study Using an Immunochromatographic Dipstick Test, Enzyme-Linked Immunosorbent Assay, and PCR [PDF]

, 2002
Current zoonotic visceral leishmaniasis (ZVL) control programs in Brazil include the culling of Leishmania infantum-infected reservoir dogs, a strategy that has failed to prevent a rise of canine and human ZVL cases over the past decade.
Bruce Alex, Bruce Alex, Clive R. Davies, Clive R. Davies, J. Clin Microbiol, Richard Reithinger, Richard Reithinger, Rupert J. Quinnell, Rupert J. Quinnell   +8 more
core   +3 more sources

Leishmania tarentolae: taxonomic classification and its application as a promising biotechnological expression host

, 2019
In this review, we summarize the current knowledge concerning the eukaryotic protozoan parasite Leishmania tarentolae, with a main focus on its potential for biotechnological applications.
Klatt, S., Konthur, Z., Maslov, D., Simpson, L.   +3 more
core   +1 more source

Can cutaneous leishmaniasis provoke a resurgence of kala-azar in the Indian subcontinent?

BMC Infectious Diseases
Background The ongoing kala-azar elimination program in Nepal is based on the assumption of anthroponotic transmission of the protozoan parasite Leishmania donovani. This parasite species was recently also found in lesions of cutaneous leishmaniasis (CL)
Narayan Raj Bhattarai, Keshav Rai, Surendra Uranw, Dhan Keshar Khadka, Basudha Khanal, Gokarna Dahal, Sushmita Pradhan, Sushil Dhakal, Pieter Monsieurs, Tanyth de Gooyer, Kristien Cloots, Epco Hasker, Gert Van der Auwera   +12 more
doaj   +1 more source

De-novo design of complementary (antisense) peptide mini-receptor inhibitor of interleukin 18 (IL-18).

, 2004
Complementary (antisense) peptide mini-receptor inhibitors are complementary peptides designed to be receptor-surrogates that act by binding to selected surface features of biologically important proteins thereby inhibiting protein-cognate receptor ...
Bhakoo, Ashish, Heal, Jonathan R, Keller, Michael, Miller, Andrew D, Raynes, John G   +4 more
core   +1 more source

Gene expression in Leishmania is regulated predominantly by gene dosage [PDF]

, 2017
Leishmania tropica, a unicellular eukaryotic parasite present in North and East Africa, the Middle East, and the Indian subcontinent, has been linked to large outbreaks of cutaneous leishmaniasis in displaced populations in Iraq, Jordan, and Syria. Here,
Berriman, Matthew, Beverley, Stephen M., Cotton, James A., Durrant, Caroline, Grigg, Michael E., Iantorno, Stefano A., Khan, Asis, Myler, Peter, Ouellette, Marc, Sacks, David L., Sanders, Mandy J., Warren, Wesley C., Weiss, Louis M.   +12 more
core   +3 more sources