Results 91 to 100 of about 80,278 (299)
Paromomycin: Uptake and resistance in Leishmania donovani [PDF]
Molecular and Biochemical Parasitology, 2009 Paromomycin is currently in phase IV clinical trials against leishmaniasis. In the present work we elucidate the effect and mechanism of uptake of paromomycin in Leishmania donovani. The in vitro sensitivities of both promastigotes and amastigotes were determined to this aminoglycoside. Association of paromomycin with L.
Michael P. Barrett +4 more
openaire +3 more sources
Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxification. [PDF]
PLoS ONE, 2009 BACKGROUND:Glyoxalase I is a metalloenzyme of the glyoxalase pathway that plays a central role in eliminating the toxic metabolite methyglyoxal. The protozoan parasite Leishmania donovani possesses a unique trypanothione dependent glyoxalase system ...
Swati C Chauhan, Rentala Madhubala
doaj +1 more source
Parasite Immunology, Volume 47, Issue 10, October 2025.ABSTRACT Human babesiosis is an emerging infectious disease caused by a bloodborne single‐celled parasite belonging to the genus Babesia. Cases of human babesiosis are commonly reported in the United States, Western Europe and Asia. In the United States, the two major causative agents are Babesia microti and Babesia duncani.
Simone Haak +4 more
wiley +1 more source
Carbon Dioxide Assimilation by Leishmania donovani [PDF]
Nature, 1960 WHILE studying the glucose metabolism of Leishmania donovani, the protozoan organism causing visceral leishmaniasis, it has been found that cell suspensions of this organism in a saline-bicarbonate buffer containing glucose can assimilate, a measurable amount of carbon dioxide along with the formation of different acidic end products1.
J. J. Ghosh +2 more
openaire +3 more sources
Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.
PLoS Neglected Tropical Diseases, 2020 BackgroundThe disturbance of host metabolic pathways by Leishmania parasites has crucial consequences for the activation status of immune cells and the outcome of infection.
Carolina Ferreira +11 more
doaj +1 more source
Frontiers in Microbiology, 2017 The outcome of Leishmania infection depends on parasite abilities to evade host immune response and its survival in hostile environment of host macrophages.
N. Tiwari +6 more
semanticscholar +1 more source
Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
ChemMedChem, Volume 20, Issue 18, September 25, 2025.This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali +7 more
wiley +1 more source
, 2019 In this review, we summarize the current knowledge concerning the eukaryotic protozoan parasite Leishmania tarentolae, with a main focus on its potential for biotechnological applications.
Klatt, S. +3 more
core +1 more source
Cell Reports, 2016 Participation of B cells in the immune response by various antibody-independent mechanisms has recently been uncovered. B cells producing cytokines have been described for several infections and appear to regulate the adaptive immune response.
Sasha Silva-Barrios +6 more
doaj +1 more source
The role of PD-1 in regulation of macrophage apoptosis and its subversion by Leishmania donovani
Clinical & Translational Immunology, 2017 Programmed death‐1 receptor (PD‐1) expressed in many immune cells is known to trigger T‐cell exhaustion but the significance of macrophage‐associated PD‐1 in relevance to macrophage apoptosis is not known.
Shalini Roy +5 more
semanticscholar +1 more source