Results 111 to 120 of about 35,037 (252)

Comparative study of the biological behaviour in hamster of two isolates of leishmania characterized respectively as L. major-like and L. donovani

Revista do Instituto de Medicina Tropical de São Paulo, 1988
Hamster inoculated intraperitoneally with 1 x 10(7) parasites of L. donovani and L. major-like of the New World were studied in groups of 15, 30, 60 and 90 days of infection. The parasite load and density showed progressive increase with the evolution of
M. I. S. Duarte, M. D. Laurenti, H. F. Andrade Jr., C. E. P. Corbett   +3 more
doaj   +1 more source

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]

, 2014
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S., Chapman, Melissa S., Galvin, Brendan D., Li, Zhiru, Pollastri, Michael P., Poole, Catherine B., Villemaine, Estelle, Wyatt, Paul G.   +7 more
core   +4 more sources

Effective Tetradentate Compound Complexes against Leishmania spp. that Act on Critical Enzymatic Pathways of These Parasites

Molecules, 2018
The spectrum and efficacy of available antileishmanial drugs is limited. In the present work we evaluated in vitro the antiproliferative activity of 11 compounds based on tetradentate polyamines compounds against three Leishmania species (L. braziliensis,
Kristína Urbanová, Inmaculada Ramírez-Macías, Rubén Martín-Escolano, María José Rosales, Olaf Cussó, Joan Serrano, Anna Company, Manuel Sánchez-Moreno, Miquel Costas, Xavi Ribas, Clotilde Marín   +10 more
doaj   +1 more source

Author response for "The catalytic core of Leishmania donovani RECQ helicase unwinds a wide spectrum of DNA substrates and is stimulated by replication protein A"

, 2021
Kumari Shikha, Gugulothu Sriram Bharath, Swagata Mukhopadhyay, Mayukh Chakraborty, Susmita Ghosh, Suparna Khatun, Debajyoti De, Amar Nath Gupta, Agneyo Ganguly   +8 more
openalex   +1 more source

Leishmania donovani donovani and Leishmania donovani chagasi as antigens in a direct agglutination assay for the diagnosis of kala-azar.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1990
The need for a reliable method for the immunological diagnosis of kala-azar is imperative. Leishmania donovani donovani and L. donovani chagasi culture promastigotes were compared as antigens in a direct agglutination test (DAT) for the diagnosis of visceral leishmaniasis in Brazil.
C R, Andrade, A E, Nascimento, P M, Moura, P P, Andrade   +3 more
openaire   +1 more source

Cysteine Cross-linking Defines the Extracellular Gate for the Leishmania donovani Nucleoside Transporter 1.1 (LdNT1.1) [PDF]

, 2012
Raquel Valdés, Ujwal Shinde, Scott M. Landfear   +2 more
openalex   +1 more source

An arginine deprivation response pathway is induced in Leishmania during macrophage invasion [PDF]

, 2016
Amino acid sensing is an intracellular function that supports nutrient homeostasis, largely through controlled release of amino acids from lysosomal pools.
Balno, Caitlin, Bendelak, Keren, Ephros, Moshe, Goldman-Pinkovich, Adele, Jardim, Armando, Myler, Peter J, Rentsch, Doris, Strasser, Rona, Wiese, Martin, Zeituni-Molad, Michal, Zilberstein, Dan   +10 more
core   +3 more sources

Sero-prevalence of Leishmania donovani infection in labour migrants and entomological risk factors in extra-domestic habitats of Kafta-Humera lowlands - kala-azar endemic areas in the northwest Ethiopia [PDF]

, 2015
Wossenseged Lemma, Habte Tekie, Solomon Yared, Meshesha Balkew, Teshome Gebre-Michael, Alon Warburg, Asrat Hailu   +6 more
openalex   +1 more source

l-Arginine Uptake by Cationic Amino Acid Transporter Promotes Intra-Macrophage Survival of Leishmania donovani by Enhancing Arginase-Mediated Polyamine Synthesis

Frontiers in Immunology, 2017
The survival of intracellular protozoan parasite, Leishmania donovani, the causative agent of Indian visceral leishmaniasis (VL), depends on the activation status of macrophages. l-Arginine, a semi-essential amino acid plays a crucial regulatory role for
Abhishek Mandal, Sushmita Das, Ajay Kumar, Saptarshi Roy, Sudha Verma, Ayan Kumar Ghosh, Ruby Singh, Kumar Abhishek, Savita Saini, Savita Saini, Abul Hasan Sardar, Bidyut Purkait, Ashish Kumar, Chitra Mandal, Pradeep Das   +14 more
doaj   +1 more source

The use of K39 test in the diagnosis of visceral leishmaniasis [PDF]

, 2007
From time to time patients admitted with fever of unknown origin prove to be a diagnostic dilemma. While textbooks describe typical symptoms and signs, and also diagnostic tests, these are not always helpful.
Sciberras, Robert
core