Results 61 to 70 of about 29,719 (208)

Carbon Dioxide Assimilation by Leishmania donovani [PDF]

Nature, 1960
WHILE studying the glucose metabolism of Leishmania donovani, the protozoan organism causing visceral leishmaniasis, it has been found that cell suspensions of this organism in a saline-bicarbonate buffer containing glucose can assimilate, a measurable amount of carbon dioxide along with the formation of different acidic end products1.
J. J. Ghosh, J. J. Ghosh, A. N. Chatterjee   +2 more
openaire   +3 more sources

Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxification. [PDF]

PLoS ONE, 2009
BACKGROUND:Glyoxalase I is a metalloenzyme of the glyoxalase pathway that plays a central role in eliminating the toxic metabolite methyglyoxal. The protozoan parasite Leishmania donovani possesses a unique trypanothione dependent glyoxalase system ...
Swati C Chauhan, Rentala Madhubala
doaj   +1 more source

Posttranslational modifications of heterologous proteins expressed in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
Summary The success of Nicotiana benthamiana as a workhorse for heterologous protein production is closely linked to its accessibility and tolerance to genetic manipulation, allowing efficient engineering of posttranslational protein modifications (PTMs) that are critical for the function and stability of heterologous proteins.
Kathrin Göritzer, Somanath Kallolimath, Richard Strasser   +2 more
wiley   +1 more source

Comparison of Bloodmeal Digestion and the Peritrophic Matrix in Four Sand Fly Species Differing in Susceptibility to Leishmania donovani. [PDF]

PLoS ONE, 2015
The early stage of Leishmania development in sand flies is closely connected with bloodmeal digestion. Here we compared various parameters of bloodmeal digestion in sand flies that are either susceptible (Phlebotomus argentipes and P.
Katerina Pruzinova, Jovana Sadlova, Veronika Seblova, Miroslav Homola, Jan Votypka, Petr Volf   +5 more
doaj   +1 more source

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Significantly lower anti-Leishmania IgG responses in Sudanese versus Indian visceral leishmaniasis.

PLoS Neglected Tropical Diseases, 2014
BackgroundVisceral leishmaniasis (VL), a widely distributed systemic disease caused by infection with the Leishmania donovani complex (L. donovani and L. infantum), is almost always fatal if symptomatic and untreated.
Tapan Bhattacharyya, Duncan E Bowes, Sayda El-Safi, Shyam Sundar, Andrew K Falconar, Om Prakash Singh, Rajiv Kumar, Osman Ahmed, Marleen Boelaert, Michael A Miles   +9 more
doaj   +1 more source

Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.

PLoS Neglected Tropical Diseases, 2020
BackgroundThe disturbance of host metabolic pathways by Leishmania parasites has crucial consequences for the activation status of immune cells and the outcome of infection.
Carolina Ferreira, Inês Mesquita, Ana Margarida Barbosa, Nuno Sampaio Osório, Egídio Torrado, Charles-Joly Beauparlant, Arnaud Droit, Cristina Cunha, Agostinho Carvalho, Bhaskar Saha, Jerôme Estaquier, Ricardo Silvestre   +11 more
doaj   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, Volume 6, Issue 5, May 2025.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

Refined structure of the lipophosphoglycan of Leishmania donovani. [PDF]

Journal of Biological Chemistry, 1992
The primary structure of the major surface glycoconjugate of Leishmania donovani parasites, a lipophosphoglycan, has been further characterized. The repeating PO4-6Galp beta 1-4Man disaccharide units, which are a salient feature of the molecule, are shown to terminate with one of several neutral structures, the most abundant of which is the branched ...
Thomas, Jerry R., McConville, Malcolm J., Thomas-Oates, Jane E., Homans, Steven W., Ferguson, Michael A. J., Gorin, Philip A. J., Greis, Kenneth D., Turco, Salvatore J.   +7 more
openaire   +2 more sources

Alkyl Tail Variation on Chalcone‐Based Quaternary Pyridinium Salts as Rule‐of‐Thumb for Antimicrobial Activity

Archiv der Pharmazie, Volume 358, Issue 5, May 2025.
A small library of quaternary pyridinium salts was developed as membrane‐interacting antimicrobials. In particular, analogs 4–6 effectively inhibited Staphylococcus aureus growth, while 4 and 5 were active against Escherichia coli. Molecular dynamics studies supported the capability of derivative 5 to efficiently interact with the Gram‐positive ...
Francesca Seghetti, Riccardo Ocello, Alessandra Bisi, Matteo Masetti, Silvia Gobbi, Federico Falchi, Giovanna Angela Gentilomi, Francesca Bonvicini, Federica Belluti   +8 more
wiley   +1 more source