Results 71 to 80 of about 2,355 (146)

Therapeutic Effect of Barberry (Berberis vulgaris) Root Extract on Experimental Cutaneous Leishmaniosis in a BALB/c Mouse Model

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
Barberry (Berberis vulgaris) root extract shows potential in treating cutaneous leishmaniasis caused by Leishmania major. In a BALB/c mouse model, treatment significantly reduced wound size and parasite load while enhancing inflammatory markers IL‐1 and IL‐6. These results highlight barberry's therapeutic promise against leishmaniasis.
Sadegh Shirian, Morteza Norouzi Cholcheh, Saeed Habibian Dehkordi, Behnam Bakhtiari Moghadam   +3 more
wiley   +1 more source

Feline leishmaniosis due to Leishmania infantum (syn. L. chagasi)

Journal of the Hellenic Veterinary Medical Society, 2018
From the beginning of the 20th century, feline infections by at least eight different Leishmania species have been sporadically reported, worldwide. In the Mediterranean countries, feline infection imposed by L. infantum, the aetiological agent of canine leishmaniosis and human visceral and cutaneous leishmaniasis, is of particular importance, because ...
M CHATZIS, MN SARIDOMICHELAKIS, AF KOUTINAS   +2 more
openaire   +2 more sources

Vaccination with L. infantum chagasi nucleosomal histones confers protection against new world cutaneous leishmaniasis caused by Leishmania braziliensis.

PLoS ONE, 2012
BackgroundNucleosomal histones are intracellular proteins that are highly conserved among Leishmania species. After parasite destruction or spontaneous lysis, exposure to these proteins elicits a strong host immune response.
Marcia W Carneiro, Diego M Santos, Kiyoshi F Fukutani, Jorge Clarencio, Jose Carlos Miranda, Claudia Brodskyn, Aldina Barral, Manoel Barral-Netto, Manuel Soto, Camila I de Oliveira   +9 more
doaj   +1 more source

IL‐12 and IFN‐γ in Response to Leishmania Infantum Antigens in Felines From an Endemic Area for Visceral Leishmaniasis

Parasite Immunology, Volume 47, Issue 8, August 2025.
ABSTRACT Visceral leishmaniasis is a potentially fatal zoonosis with an increasing incidence. Most infected felines present the disease in its subclinical form and demonstrate greater resistance to parasitemia than dogs. However, the role of cellular immunity in felines is still poorly understood. This study measured serum levels of interleukin (IL)‐12
João Victor Lé Lode, Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Valéria Marçal Felix de Lima   +3 more
wiley   +1 more source

Estudo fitoquímico e atividades leishmanicida, anticolinestarásica e antioxidante de extratos de Annona glabra L. (araticum panã)

Revista de Ciências Farmacêuticas Básica e Aplicada, 2015
O objetivo deste estudo foi investigar as principais classes de compostos químicos presentes em Annona grabra L. (Araticum panã), e avaliar o seu potencial biológico analisando suas atividades antioxidante, antiacetilcolinesterase e leishmanicida.
Antonio Adailson de Sousa Silva, Joana Barros Alexandre, Larissa Guerra Vieira, Suliane Praciano Rodrigues, Maria José Cajazeiras Falcão, Selene Maia Morais   +5 more
doaj   +2 more sources

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Expression of leukosialin (CD43) defines a major intrahepatic T cell subset associated with protective responses in visceral leishmaniasis

Parasites & Vectors, 2015
Background Leishmaniasis is a neglected vector-borne tropical disease caused by Leishmania protozoa that are transmitted to mammalian hosts by infected sand flies.
Dirlei Nico, Naiara Maran, Leonardo Santos, Erivan Schnaider Ramos-Junior, Natália Rodrigues Mantuano, Joseane Lima Prado Coutinho, Andre Macedo Vale, Celio Geraldo Freire-de-Lima, Adriane Todeschini, Juliany Cola Fernandes Rodrigues, Clarisa Beatriz Palatnik-de-Sousa, Alexandre Morrot   +11 more
doaj   +1 more source

Impact of leishmaniasis on public health

Journal of Venomous Animals and Toxins including Tropical Diseases, 2006
Leishmaniasis is a parasitic zoonosis caused by protozoans of the genus Leishmania transmitted by insects known as phlebotomines, which are found in wild or urban environments.
L. B Camargo, H. Langoni
doaj   +1 more source

Mucocutaneous Leishmaniasis With Oral Involvement: A Case Report

Case Reports in Dentistry, Volume 2025, Issue 1, 2025.
The primary objective of the present study is the retrospective analysis of a clinical case of oral leishmaniasis treated at Parma Hospital and a review of the literature on mucosal leishmaniasis (ML) with oral cavity involvement. We report the case of a patient diagnosed in 2017 with mucocutaneous leishmaniasis who was referred to our clinic due to ...
Pierpaolo De Francesco, Paolo Vescovi, Claudio Feliciani, Roberta Iaria, Luigi Corcione, Ilaria Giovannacci, Vlaho Brailo   +6 more
wiley   +1 more source

A Century of Epidemiological Advances in Cutaneous and Visceral Leishmaniasis in Algeria

Journal of Parasitology Research, Volume 2025, Issue 1, 2025.
Leishmaniasis is a group of diseases transmitted by sandflies, affecting humans and animals, with three clinical presentations: cutaneous, mucosal, and visceral. The disease is caused by the parasite Leishmania and is a significant global health issue, with approximately two million cases annually and 350 million people at risk.
Naouel Eddaikra, Razika Benikhlef, Denis Sereno, Satabdi Datta Choudhury   +3 more
wiley   +1 more source