Results 61 to 70 of about 2,376 (150)

Antiprotozoal action of synthetic cinnamic acid analogs

Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was ...
Ana Paula de Azevedo dos Santos, Saara Nery Fialho, Daniel Sol Sol de Medeiros, Ana Fidelina Gómez Garay, Jorge Alfonso Ruiz Diaz, Maria Celeste Vega Gómez, Carolina Bioni Garcia Teles, Leonardo de Azevedo Calderon   +7 more
doaj   +1 more source

Molecular characterization of Trypanosoma cruzi and Leishmania spp. coinfection in mammals of Venezuelan coendemic areas

Journal of Vector Borne Diseases, 2019
Background & objectives: Trypanosoma cruzi and Leishmania spp. are protozoans that cause American trypanosomiasis and leishmaniasis, respectively. In endemic foci where both diseases coincide, coinfection can occur.
M Viettri, L Herrera, C M Aguilar, A Morocoima, J Reyes, M Lares, D Lozano-Arias, R García-Alzate, T Chacón, M D Feliciangeli, E Ferrer   +10 more
doaj   +1 more source

Impact of LbSapSal Vaccine in Canine Immunological and Parasitological Features before and after Leishmania chagasi-Challenge.

PLoS ONE, 2016
Dogs represent the most important domestic reservoir of L. chagasi (syn. L. infantum). A vaccine against canine visceral leishmaniasis (CVL) would be an important tool for decreasing the anxiety related to possible L.
Lucilene Aparecida Resende, Rodrigo Dian de Oliveira Aguiar-Soares, Henrique Gama-Ker, Bruno Mendes Roatt, Ludmila Zanandreis de Mendonça, Marina Luiza Rodrigues Alves, Denise da Silveira-Lemos, Rodrigo Corrêa-Oliveira, Olindo Assis Martins-Filho, Márcio Sobreira Silva Araújo, Ricardo Toshio Fujiwara, Nelder Figueiredo Gontijo, Alexandre Barbosa Reis, Rodolfo Cordeiro Giunchetti   +13 more
doaj   +1 more source

Cortisol Regulates PD‐1 and IL‐12 in Canine Leishmaniasis

Parasite Immunology, Volume 48, Issue 2, February 2026.
ABSTRACT Canine visceral leishmaniasis (CanL) is a tropical zoonosis caused by Brazil's protozoan Leishmania (L.) infantum. Disorders in the hypothalamic–pituitary–adrenal (HPA) axis have been reported in human and experimental visceral leishmaniasis, but not yet in canine leishmaniasis.
Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Mayla Abbas Guimarães, Bianca Maciel Marques de Souza, Sofia Furrier Soares, Luiz Eduardo Amador Loiola Pereira, Valéria Marçal Felix de Lima   +6 more
wiley   +1 more source

Molecular and serological detection of tick-borne pathogens in dogs from an area endemic for Leishmania infantumin Mato Grosso do Sul, Brazil

Revista Brasileira de Parasitologia Veterinária
Tick-borne pathogens affect a wide range of vertebrate hosts. To identify tick-borne pathogens among dogs from Campo Grande, MS, Brazil testing seropositive for Leishmania infantum (syn. L.
Keyla Carstens Marques de Sousa, Marcos Rogério André, Heitor Miraglia Herrera, Gisele Braziliano de Andrade, Marcia Mariza Gomes Jusi, Luciana Ladislau dos Santos, Wanessa Teixeira Gomes Barreto, Rosangela Zacarias Machado, Gilson Pereira de Oliveira   +8 more
doaj   +1 more source

Sex in Immune Cells and Parasitic Diseases — A Complex Relationship

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Epidemiological studies consistently show that many parasitic diseases affect males more frequently than females. These disparities are multifactorial, arising partly from gender‐specific behaviors that influence exposure risk and health‐seeking practices, especially in low‐ and middle‐income countries. Increasing evidence also highlights that
Barbara Honecker, Charlotte Sophie Hansen, Hanna Lotter   +2 more
wiley   +1 more source

Diagnostic Challenges in Visceral Leishmaniasis in a 17‐Month‐Old Female: A Case Report

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Visceral leishmaniasis is an uncommon infectious disease. In this report, we present a case of VL in a 17‐month‐old child who presented with a fever and splenomegaly. After the patient failed to respond to several courses of antibiotics, a bone marrow aspirate confirmed the definitive diagnosis of VL, which was successfully treated with ...
Ahmed Sheikh Sobeh, Manal Soufan, Tasneem Sarakbi, Alaa Jaddouh, Feras Alharroush   +4 more
wiley   +1 more source

Comparative proteomic analysis of antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum chagasi lines

Molecular and Biochemical Parasitology, 2013
The emergence of drug-resistant Leishmania species is a significant problem in several countries. A comparative proteomic analysis of antimony-susceptible and antimony-resistant Leishmania braziliensis (LbSbR) and Leishmania infantum chagasi (LcSbR) lines was carried out using two-dimensional gel electrophoresis (2-DE) followed by mass spectrometry (LC/
Matrangolo, Fabiana S.V., Liarte, Daniel B., Andrade, Laila C., de Melo, Melina F., Andrade, Juvana M., Ferreira, Rafael F., Santiago, André S., Pirovani, Carlos P., Silva-Pereira, Rosiane A., Murta, Silvane M.F.   +9 more
openaire   +2 more sources

Antileishmanial activity and immunomodulatory effect of secosubamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae)

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: Visceral leishmaniasis is a complex neglected tropical disease caused by Leishmania donovani complex. Its current treatment reveals strong limitations, especially high toxicity.
Thais A. da Costa-Silva, Geanne A. Alves Conserva, Andrés J. Galisteo Jr, Andre G. Tempone, João Henrique G. Lago   +4 more
doaj   +1 more source

Vaccination with L. infantum chagasi nucleosomal histones confers protection against new world cutaneous leishmaniasis caused by Leishmania braziliensis.

PLoS ONE, 2012
BackgroundNucleosomal histones are intracellular proteins that are highly conserved among Leishmania species. After parasite destruction or spontaneous lysis, exposure to these proteins elicits a strong host immune response.
Marcia W Carneiro, Diego M Santos, Kiyoshi F Fukutani, Jorge Clarencio, Jose Carlos Miranda, Claudia Brodskyn, Aldina Barral, Manoel Barral-Netto, Manuel Soto, Camila I de Oliveira   +9 more
doaj   +1 more source