Neutrophils Reduce the Parasite Burden in Leishmania (Leishmania) amazonensis-Infected Macrophages
Studies on the role of neutrophils in Leishmania infection were mainly performed with L. (L) major, whereas less information is available for L. (L) amazonensis. Previous results from our laboratory showed a large infiltrate of neutrophils in the site of infection in a mouse strain resistant to L. (L.) amazonensis (C3H/HePas).
Souza Carmo, Erico Vinicius de UNIFESP +2 more
openaire +5 more sources
Effects of Brazilian propolis on Leishmania amazonensis [PDF]
Leishmaniasis, an endemic parasitosis that leads to chronic cutaneous, mucocutaneous or visceral lesions, is part of those diseases, which still requires improved control tools. Propolis has shown activities against different bacteria, fungi, and parasites.
Ayres, Diana Copi +2 more
openaire +4 more sources
INTRODUCTION: Leishmania species cause skin, mucosal, and disseminated lesions. We studied the effects of three Leishmania species on ileal morphology in mice.
Amanda Gubert Alves dos Santos +5 more
doaj +1 more source
Health Benefits and Therapeutic Potential of Quercetin
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley +1 more source
Nueva estrategia terapéutica basada en nanotecnología contra leishmaniasis tegumentaria en Ecuador = New pharmacological strategy based in nanotechnology against cutaneous leishmaniasis in Ecuador [PDF]
Leishmaniasis is an endemic disease with wide distribution in tropical and subtropical regions around the world. It is considered that the incidence of this infection would be increased due to the progressive urbanization process which consequence is the
Loayza Villa, María Fernanda
core
Cell-to-cell transfer of Leishmania amazonensis amastigotes is mediated by immunomodulatory LAMP-rich parasitophorous extrusions [PDF]
The last step of Leishmania intracellular life cycle is the egress of amastigotes from the host cell and their uptake by adjacent cells. Using multidimensional live imaging of long-term-infected macrophage cultures we observed that Leishmania amazonensis
Goto, Hiro +6 more
core +3 more sources
Leishmaniasis is a group of diseases caused by protozoa of Leishmania genus. The currently available treatments for this disease are expensive, present high toxicity and are associated to difficulties of healing and parasite resistance.
D. C. O. Nunes +7 more
semanticscholar +1 more source
Piplartine as an Innovative Natural Product With Dual Antiparasitic and Immunomodulatory Actions
Neglected tropical diseases (NTDs) remain a major global health burden, disproportionately affecting low‐ and middle‐income regions and demanding innovative therapeutic strategies. This review summarizes current evidence on piplartine (piperlongumine), a naturally occurring amide from Piper species with broad antiparasitic and immunomodulatory ...
Lucas Fukui-Silva +4 more
wiley +1 more source
The outcome of Leishmania infections is determined by both the parasite species and the host genetic makeup. While much has been learned regarding immune responses to this parasite, our knowledge on parasite-derived factors is limited.
Reynolds K. B. Brobey +3 more
doaj +1 more source
Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice. [PDF]
We recently demonstrated that statins mediate protection against intracellular pathogens, Mycobacterium tuberculosis and Listeria monocytogenes in mice.
Brombacher, F. +4 more
core +1 more source

