Results 81 to 90 of about 6,816 (177)

A Serine Protease from a Detergent-soluble Extract of Leishmania (Leishmania) amazonensis

Zeitschrift für Naturforschung C, 2004
Abstract Proteases mediate important crucial functions in parasitic diseases, and their characterization contributes to the understanding of host-parasite interaction. A serine protease was purified about 43-fold with a total recovery of 60% from a detergent-soluble extract of promastigotes of Leishmania amazonensis.
Raquel Elisa, da Silva Lopez, Salvatore Giovanni, De Simone   +1 more
openaire   +2 more sources

Neutrophils Reduce the Parasite Burden in Leishmania (Leishmania) amazonensis-Infected Macrophages

PLoS ONE, 2010
Studies on the role of neutrophils in Leishmania infection were mainly performed with L. (L) major, whereas less information is available for L. (L) amazonensis. Previous results from our laboratory showed a large infiltrate of neutrophils in the site of infection in a mouse strain resistant to L. (L.) amazonensis (C3H/HePas).
Souza Carmo, Erico Vinicius de UNIFESP, Katz, Simone UNIFESP, Barbieri, Clara Lucia UNIFESP   +2 more
openaire   +5 more sources

In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195

Memorias do Instituto Oswaldo Cruz, 2018
BACKGROUND Leishmaniasis, one of the most neglected diseases, is a serious public health problem in many countries, including Brazil. Currently available treatments require long-term use and have serious side effects, necessitating the development of new
Carlos Eduardo Sampaio Guedes, Beatriz Rocha Simões Dias, Antonio Luis de Oliveira Almeida Petersen, Kercia Pinheiro Cruz, Niara de Jesus Almeida, Daniela Rodrigues Andrade, Juliana Perrone Bezerra de Menezes, Valéria de Matos Borges, Patricia Sampaio Tavares Veras   +8 more
doaj   +1 more source

Modulation of fibroblast behavior by Leishmania: a pathway to understanding disease progression in cutaneous leishmaniasis

BMC Microbiology
Leishmaniasis is a parasitic infection caused by obligatory intracellular protozoa of the Leishmania genus. Macrophages are the main cell for Leishmania parasites that play a key role in immune response against it.
Tarcisio Navegante de Queiroz Filho, Brenda Furtado Costa, Ana Paula Drummond Rodrigues   +2 more
doaj   +1 more source

Arginase expression modulates nitric oxide production in Leishmania (Leishmania) amazonensis

PLOS ONE, 2017
Arginase is an enzyme that converts L-arginine to urea and L-ornithine, an essential substrate for the polyamine pathway supporting Leishmania (Leishmania) amazonensis replication and its survival in the mammalian host. L-arginine is also the substrate of macrophage nitric oxide synthase 2 (NOS2) to produce nitric oxide (NO) that kills the parasite ...
Stephanie Maia Acuña, Juliana Ide Aoki, Maria Fernanda Laranjeira-Silva, Ricardo Andrade Zampieri, Juliane Cristina Ribeiro Fernandes, Sandra Marcia Muxel, Lucile Maria Floeter-Winter   +6 more
openaire   +4 more sources

Evaluación del efecto del ácido nalidíxico, ampicilina, kanamicina, penicilina G y polimixina B en los cultivos de promastigotes de leishmania

Biomédica: revista del Instituto Nacional de Salud, 1992
Se evaluó el efecto de diferentes concentraciones de ácido nalidíxico, ampicilina, kanarnicina, penicilina G y polimixina B, sobre la población de promastigotes de Leishmania braziliensis braziliensis , Leishmania donovani chagasi y Leishmania mexicana ...
Sofía Duque Beltrán, Augusto Corredor Arjona, Marleny Montilla Moreno, Dioselina Peláez Carvajal   +3 more
doaj   +1 more source

CENTRAL NERVOUS SYSTEM INVOLVEMENT IN EXPERIMENTAL INFECTION WITH LEISHMANIA (LEISHMANIA) AMAZONENSIS

The American Journal of Tropical Medicine and Hygiene, 2003
We describe the pathologic alterations of the central nervous system (CNS) observed in experimental tegumentary leishmaniasis in BALB/c and Swiss mice. The mice were subcutaneously infected with 104 amastigotes of Leishmania (Leishmania) amazonensis. Animals were killed and brains were removed for histologic and immunocytochemical studies.
Abreu-Silva, Ana Lucia, Calabrese, Katia da Silva, Tedesco, Roberto Carlos UNIFESP, Mortara, Renato Arruda UNIFESP, Costa, SCG de   +4 more
openaire   +2 more sources

Assessment of PCR in the detection of Leishmania spp in experimentally infected individual phlebotomine sandflies (Diptera: Psychodidae: Phlebotominae)

Revista do Instituto de Medicina Tropical de São Paulo, 2002
DNA amplification by the polymerase chain reaction (PCR) was applied in the investigation of the presence of Leishmania (Kinetoplastida: Trypanosomatidae) parasites in single phlebotomine sandflies.
MICHALSKY Érika M., FORTES-DIAS Consuelo L., PIMENTA Paulo F.P., SECUNDINO Nágila F.C., DIAS Edelberto S.   +4 more
doaj  

Characterization of Sv129 Mice as a Susceptible Model to Leishmania amazonensis

Frontiers in Medicine, 2019
Leishmaniasis is a complex of neglected diseases caused by parasites of the genus Leishmania, such as Leishmania (Leishmania) amazonensis, the ethiologic agent of diffuse cutaneous leishmaniasis in Brazil. In this work, we investigated a new experimental
Júlio Souza dos-Santos, Luan Firmino-Cruz, Tadeu Diniz Ramos, Alessandra Marcia da Fonseca-Martins, Diogo Oliveira-Maciel, Juliana Valente Rodrigues De-Medeiros, Suzana Passos Chaves, Daniel Claudio Oliveira Gomes, Herbert Leonel de Matos Guedes, Herbert Leonel de Matos Guedes   +9 more
doaj   +1 more source

Extracellular Vesicles Released by Leishmania (Leishmania) amazonensis Promastigotes with Distinct Virulence Profile Differently Modulate the Macrophage Functions. [PDF]

Microorganisms, 2023
Zauli RC, de Souza Perez IC, de Morais ACC, Ciaccio AC, Vidal AS, Soares RP, Torrecilhas AC, Batista WL, Xander P.   +8 more
europepmc   +1 more source