Results 71 to 80 of about 6,626 (173)

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

Comprehensive Analysis of Structure Activity Relationships in Quinoxaline Derivatives Covering Antimicrobial Applications

ChemistrySelect, Volume 11, Issue 14, 13 April 2026.
ABSTRACT Antimicrobial resistance (AMR) has emerged as one of the most critical global health challenges, undermining the clinical efficacy of existing antibiotics and threatening modern therapeutic strategies. The ongoing misuse and overuse of antimicrobial agents have accelerated the evolution of resistant bacterial strains and parasites ...
Subham Kumar Vishwakarma, Fernando Rogério Pavan, Cesar Augusto Roque‐Borda   +2 more
wiley   +1 more source

Drosophila Model of Leishmania amazonensis Infection

BIO-PROTOCOL, 2017
This protocol describes how to generate and harvest antibody-free L. amazonensis amastigotes, and how to infect adult Drosophila melanogaster with these parasites. This model recapitulates key aspects of the interactions between Leishmania amastigotes and animal phagocytes.
Okuda, Kendi, Silverman, Neal
openaire   +5 more sources

The Regulatory Effect of Histone Deacetylase (HDAC) 1 and 2 on iNOS, IL‐6, TNF‐α and IL‐10 Expression in Canine Macrophages Infected With Leishmania infantum

Parasite Immunology, Volume 48, Issue 4, April 2026.
ABSTRACT Zoonotic visceral leishmaniasis is caused by Leishmania (Leishmania) infantum. Dogs are considered the most critical urban reservoirs of L. (L.) infantum due to their high infection rate and direct transmission to humans. The parasite has developed mechanisms to evade the host's defence system by inhibiting macrophage activation, thereby ...
Gabriela Lovizutto Venturin, Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Gabriela Torres Rebech, Flávia Lombardi Lopes, Valéria Marçal Felix de Lima   +5 more
wiley   +1 more source

Leishmania amazonensis in dog with clinical diagnosis of visceral leishmaniasis in Paraná State, Brazil – a case report
Leishmania amazonensis em cão com quadro clínico de leishmaniose visceral no Estado do Paraná, Brasil – relato de caso

Semina: Ciências Agrárias, 2012
Leishmaniasis are antropozoonoses involving various species of Leishmania and hosts, with variable clinical presentations and considered of great importance to public health.
Patrícia Mendes Pereira, Regina Mitsuka Breganó, Eloiza Teles Caldart, Italmar Teodorico Navarro, Valdair Elemar Camargo Junior, Aline Rafaeli Hoffmann   +5 more
doaj  

Phytochemical and Biological Evaluation of Leaves, Stems, and Roots of Schinus weinmanniifolia Mart. Ex Engl.

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
Ethanolic extracts from leaves, stems, and roots of Schinus weinmanniifolia Mart. ex Engl. were evaluated for phytochemical composition and biological activities. The extracts exhibited antioxidant, photoprotective, and antimicrobial activity, without hemolytic effects or cytotoxicity at active concentrations. Syringic acid, epicatechin, and rutin were
João Andrade, Adriana Araújo de Almeida‐Apolonio, Fabiana Gomes da Silva Dantas, José Irlan da Silva Santos, Andréia Sangalli, Melyssa Negri, Deisiany Gomes Ferreira, Claudia Andrea Lima Cardoso, Thiago Luis Aguayo de Castro, Aline dos Santos Garcia Gomes, Rhagner Bonono, Liliana Fernandes, Maria Elisa Rodrigues, Mariana Contente Rangel Henriques, Kelly Mari Pires de Oliveira   +14 more
wiley   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, Volume 293, Issue 6, Page 1681-1707, March 2026.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Phlebotomine fauna (Diptera: Psychodidae) of an American cutaneous leishmaniasis endemic area in the state of Mato Grosso do Sul, Brazil

Memorias do Instituto Oswaldo Cruz, 2009
The occurrence of an outbreak of cutaneous leishmaniasis associated with Leishmania (Leishmania) amazonensis in the municipality of Bela Vista, state of Mato Grosso do Sul, Brazil, and the absence of information on its vectors in this area led the ...
Maria Elizabeth C Dorval, Geucira Cristaldo, Hilda Carlos da Rocha, Tulia Peixoto Alves, Murilo Andrade Alves, Elisa Teruya Oshiro, Alessandra Gutierrez de Oliveira, Reginaldo Peçanha Brazil, Eunice Aparecida Bianchi Galati, Rivaldo Venâncio da Cunha   +9 more
doaj   +1 more source

CENTRAL NERVOUS SYSTEM INVOLVEMENT IN EXPERIMENTAL INFECTION WITH LEISHMANIA (LEISHMANIA) AMAZONENSIS

The American Journal of Tropical Medicine and Hygiene, 2003
We describe the pathologic alterations of the central nervous system (CNS) observed in experimental tegumentary leishmaniasis in BALB/c and Swiss mice. The mice were subcutaneously infected with 104 amastigotes of Leishmania (Leishmania) amazonensis. Animals were killed and brains were removed for histologic and immunocytochemical studies.
Abreu-Silva, Ana Lucia, Calabrese, Katia da Silva, Tedesco, Roberto Carlos UNIFESP, Mortara, Renato Arruda UNIFESP, Costa, SCG de   +4 more
openaire   +2 more sources

ITS1 PCR-RFLP Diagnosis and Characterization of Leishmania in Clinical Samples and Strains from Cases of Human Cutaneous Leishmaniasis in States of the Mexican Southeast

Interdisciplinary Perspectives on Infectious Diseases, 2014
American cutaneous leishmaniasis includes a spectrum of clinical forms localized cutaneous, diffuse cutaneous, and mucocutaneous leishmaniasis which can be caused by different strains of Leishmania belonging to the L. mexicana or L.
Amalia Monroy-Ostria, Abedelmajeed Nasereddin, Victor M. Monteon, Carmen Guzmán-Bracho, Charles L. Jaffe   +4 more
doaj   +1 more source