Results 51 to 60 of about 6,816 (177)
Fusion between Leishmania amazonensis and Leishmania major parasitophorous vacuoles: live imaging of coinfected macrophages. [PDF]
PLoS Neglected Tropical Diseases, 2010 Protozoan parasites of the genus Leishmania alternate between flagellated, elongated extracellular promastigotes found in insect vectors, and round-shaped amastigotes enclosed in phagolysosome-like Parasitophorous Vacuoles (PVs) of infected mammalian ...
Fernando Real +2 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2007 The characterization of expressed sequence tags (ESTs) generated from a cDNA library of Leishmania (Leishmania) amazonensis amastigotes is described. The sequencing of 93 clones generated new L. (L.) amazonensis ESTs from which 32% are not related to any
Luciana Girotto Gentil +4 more
doaj +1 more source
Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination
Microorganisms, 2021 Leishmania, an intracellular parasite species, causes lesions on the skin and in the mucosa and internal organs. The dissemination of infected host cells containing Leishmania is crucial to parasite survival and the establishment of infection.
Amanda Rebouças +10 more
doaj +1 more source
Exploring Biological Properties of Manganese(II)‐Phenanthroline‐Based Complexes: In Vitro Insights
ChemistrySelect, Volume 11, Issue 29, 3 August 2026.Four Mn(II) complexes with phenanthroline derivatives were studied. These compounds were tested against several parasites and different human cancer cells. Despite its cytotoxicity on breast cancer, DNA seems not to be the main biological target. These complexes can drive the design and development of new metal‐based agents with improved biological ...
Roberto S. Silva +16 more
wiley +1 more source
Leishmania amazonensis Infection in Nude Mice.
Experimental Animals, 1999 Leishmania amazonensis is an intracellular protozoan parasite of macrophages. Cutaneous leishmaniasis in an immunocompetent host begins as papules or nodules followed by ulceration at the site of promastigote inoculation. In this study, the pathological changes of cutaneous leishmaniasis lesions in T cell deficient nude mice were examined.
TERABE, Masaki +5 more
openaire +3 more sources
Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
Memorias do Instituto Oswaldo Cruz, 2011 In the current study, we evaluated the mechanism of action of miltefosine, which is the first effective and safe oral treatment for visceral leishmaniasis, in Leishmania amazonensis promastigotes.
Fernanda de Aquino Marinho +7 more
doaj +1 more source
Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre +13 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 1993 We have applied both enzyme cytochemistry and immunological labeling techniques to characterize the enzyme 5'-nucleotidase (5'-Nase), at the ultrastructural level, in promastigote forms of four Leishmania species: Leishmania amazonensis, Leishmania ...
Suzana Corte-Real +2 more
doaj +1 more source
Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer
Immunology, Volume 178, Issue 3, Page 377-386, July 2026.Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros +5 more
wiley +1 more source
International Wound Journal, Volume 23, Issue 6, June 2026.ABSTRACT Chronic wounds, exacerbated by infection, aging, diabetes, and oxidative stress, remain a significant challenge in clinical management and impose a substantial burden on healthcare systems. This study presents oregano‐derived plasma polymers (OPP) as a multifunctional surface coating for advanced wound healing applications.
Jesus Romo‐Rico +7 more
wiley +1 more source