Results 41 to 50 of about 6,626 (173)

Exploring Biological Properties of Manganese(II)‐Phenanthroline‐Based Complexes: In Vitro Insights

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
Four Mn(II) complexes with phenanthroline derivatives were studied. These compounds were tested against several parasites and different human cancer cells. Despite its cytotoxicity on breast cancer, DNA seems not to be the main biological target. These complexes can drive the design and development of new metal‐based agents with improved biological ...
Roberto S. Silva, Marcos V. Palmeira‐Mello, Mikaelly P. Caet, Celisnolia M. Leite, Arieli B. Portugal, Pedro H. Machado, Alexandre B. Carvalho, Isabel Correia, Leonardo M. Moreira, Thatiana L. B. V. Simão, Elena Lasunskaia, Michelle F. Muzitano, José L. Nepomuceno‐Silva, João L. M. Wanderley, Javier Ellena, Alzir A. Batista, Mario S. Schultz   +16 more
wiley   +1 more source

Osteopontin in the host response to Leishmania amazonensis [PDF]

BMC Microbiology, 2019
Leishmania (L.) spp are intracellular eukaryotic parasites responsible for cutaneous or visceral leishmaniasis, replicating predominantly in macrophages (MF). In C57BL/6 mice virulence with L. amazonensis has been associated with inhibition of Th1 immune responses and an uncontrolled lesion development, whereas DBA/2 mice control any lesion.
Giraud, Emilie, Rouault, Eline, Fiette, Laurence, Colle, Jean-Hervé, Smirlis, Despoina, Melanitou, Evie   +5 more
openaire   +3 more sources

Leishmania mexicana in Proechimys iheringi denigratus Moojen (Rodentia, Echimyidae) in a region endemic for American cutaneous leishmaniasis

Revista da Sociedade Brasileira de Medicina Tropical, 1985
Three isolates of Leishmania were recovered from five of 27 specimens of the rodent Proechimys iheringi denigratus Moojen captured near Três Braços in the Atlantic Forest region of Bahia, Brazil.
Air C. Barretto, Norman E. Peterson, Ednaldo Lago, Ana C. Rosa, Rosely S.M. Braga, Cesar A.C. Cuba, Julio A. Vexenat, Philip D. Marsden   +7 more
doaj   +3 more sources

The use of kDNA minicircle subclass relative abundance to differentiate between Leishmania (L.) infantum and Leishmania (L.) amazonensis

Parasites & Vectors, 2017
Background Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia).
Marcello Ceccarelli, Luca Galluzzi, Aurora Diotallevi, Francesca Andreoni, Hailie Fowler, Christine Petersen, Fabrizio Vitale, Mauro Magnani   +7 more
doaj   +1 more source

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source

Leishmania in synanthropic rodents (Rattus rattus): new evidence for the urbanization of Leishmania (Leishmania) amazonensis [PDF]

Revista Brasileira de Parasitologia Veterinária, 2017
Abstract This study aimed to detect parasites from Leishmania genus, to determine the prevalence of anti-Leishmania spp. antibodies, to identify circulating species of the parasite, and to determine epidemiological variables associated with infection in rats caught in urban area of Londrina, Paraná, Brazil.
Caldart, Eloiza Teles, Freire, Roberta Lemos, Ferreira, Fernanda Pinto, Ruffolo, Bruno Bergamo, Sbeghen, Mônica Raquel, Mareze, Marcelle, Garcia, João Luis, Mitsuka-Breganó, Regina, Navarro, Italmar Teodorico   +8 more
openaire   +5 more sources

Experimental infection of Lutzomyia longipalpis fed on a patient with cutaneous leishmaniasis due to Leishmania mexicana amazonensis

Memorias do Instituto Oswaldo Cruz, 1986
The authors were able to infect phlebotomine sandflies on a human case of American Cutaneous Leishmaniasis by feeding females of Lutzomyia longipalpis on a patient with a lesion due to Leishmania mexicana amazonensis.Os autores lograram infectar ...
Leonidas M. Deane, Elizabeth Ferreira Rangel, Manoel Paes-Oliveira, Gabriel Grimaldi Junior, Hooman Momen, Nataly de Souza, Eduardo D. Wermelinger, André F. Barbosa   +7 more
doaj   +1 more source

In vitro and in vivo Anti-leishmanial Potential of [Ag (PTA) 4 ]BF 4 and [Ag(HBPz 3 )(PPh 3 )] Silver Complexes

Revista da Sociedade Brasileira de Medicina Tropical, 2022
Background: American tegumentary leishmaniasis is a parasitic disease known for being difficult to treat; therefore, the search for more effective therapeutic methods is necessary.
Pauline de Faria Soldera, Ana Flavia da Silva Chagas, Anny Maisa Vargas Brasil, Claudia Dantas Comandolli-Wyrepkowski, Marina Porchia, Antonia Maria Ramos Franco Pereira   +5 more
doaj   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source

Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis

Experimental Parasitology, 2015
HRS/J Hairless mice have been investigated as an experimental model in cutaneous leishmaniasis induced by Leishmania (Leishmania) amazonensis. The animals were inoculated with 10(6) promastigotes into the right hind footpad and the course of infection was followed up for 30, 60 and 90 days. BALB/c mice were infected and used as control.
Araujo, Vanessa Carneiro Pereira, Fukutani, Kiyoshi Ferreira, Oshiro, Elisa Teruya, Rodrigues, Patrik Oening, Rizk, Yasmin Silva, Carollo, Carlos Alexandre, Arruda, Carla Cardozo Pinto   +6 more
openaire   +2 more sources