Results 41 to 50 of about 6,816 (177)

Osteopontin in the host response to Leishmania amazonensis [PDF]

BMC Microbiology, 2019
Leishmania (L.) spp are intracellular eukaryotic parasites responsible for cutaneous or visceral leishmaniasis, replicating predominantly in macrophages (MF). In C57BL/6 mice virulence with L. amazonensis has been associated with inhibition of Th1 immune responses and an uncontrolled lesion development, whereas DBA/2 mice control any lesion.
Giraud, Emilie, Rouault, Eline, Fiette, Laurence, Colle, Jean-Hervé, Smirlis, Despoina, Melanitou, Evie   +5 more
openaire   +3 more sources

Leishmania mexicana in Proechimys iheringi denigratus Moojen (Rodentia, Echimyidae) in a region endemic for American cutaneous leishmaniasis

Revista da Sociedade Brasileira de Medicina Tropical, 1985
Three isolates of Leishmania were recovered from five of 27 specimens of the rodent Proechimys iheringi denigratus Moojen captured near Três Braços in the Atlantic Forest region of Bahia, Brazil.
Air C. Barretto, Norman E. Peterson, Ednaldo Lago, Ana C. Rosa, Rosely S.M. Braga, Cesar A.C. Cuba, Julio A. Vexenat, Philip D. Marsden   +7 more
doaj   +3 more sources

The use of kDNA minicircle subclass relative abundance to differentiate between Leishmania (L.) infantum and Leishmania (L.) amazonensis

Parasites & Vectors, 2017
Background Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia).
Marcello Ceccarelli, Luca Galluzzi, Aurora Diotallevi, Francesca Andreoni, Hailie Fowler, Christine Petersen, Fabrizio Vitale, Mauro Magnani   +7 more
doaj   +1 more source

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

Leishmania in synanthropic rodents (Rattus rattus): new evidence for the urbanization of Leishmania (Leishmania) amazonensis [PDF]

Revista Brasileira de Parasitologia Veterinária, 2017
Abstract This study aimed to detect parasites from Leishmania genus, to determine the prevalence of anti-Leishmania spp. antibodies, to identify circulating species of the parasite, and to determine epidemiological variables associated with infection in rats caught in urban area of Londrina, Paraná, Brazil.
Caldart, Eloiza Teles, Freire, Roberta Lemos, Ferreira, Fernanda Pinto, Ruffolo, Bruno Bergamo, Sbeghen, Mônica Raquel, Mareze, Marcelle, Garcia, João Luis, Mitsuka-Breganó, Regina, Navarro, Italmar Teodorico   +8 more
openaire   +5 more sources

In vitro and in vivo Anti-leishmanial Potential of [Ag (PTA) 4 ]BF 4 and [Ag(HBPz 3 )(PPh 3 )] Silver Complexes

Revista da Sociedade Brasileira de Medicina Tropical, 2022
Background: American tegumentary leishmaniasis is a parasitic disease known for being difficult to treat; therefore, the search for more effective therapeutic methods is necessary.
Pauline de Faria Soldera, Ana Flavia da Silva Chagas, Anny Maisa Vargas Brasil, Claudia Dantas Comandolli-Wyrepkowski, Marina Porchia, Antonia Maria Ramos Franco Pereira   +5 more
doaj   +1 more source

Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis

Experimental Parasitology, 2015
HRS/J Hairless mice have been investigated as an experimental model in cutaneous leishmaniasis induced by Leishmania (Leishmania) amazonensis. The animals were inoculated with 10(6) promastigotes into the right hind footpad and the course of infection was followed up for 30, 60 and 90 days. BALB/c mice were infected and used as control.
Araujo, Vanessa Carneiro Pereira, Fukutani, Kiyoshi Ferreira, Oshiro, Elisa Teruya, Rodrigues, Patrik Oening, Rizk, Yasmin Silva, Carollo, Carlos Alexandre, Arruda, Carla Cardozo Pinto   +6 more
openaire   +2 more sources

Active sesquiterpene lactones against Leishmania amazonensis and Leishmania braziliensis [PDF]

Natural Product Research, 2016
Seventeen sesquiterpene lactones (SLs) isolated from five species of the tribe Vernonieae were evaluated for their in vitro activity against promastigotes of Leishmania amazonensis and Leishmania braziliensis. Additionally, a quantitative structure activity relationship has been made, since all these natural compounds were found to have potent to mild ...
A Sosa, Susana Amaya, Efraín Salamanca, Miguel Gilabert, Alicia Bardón, Alberto Giménez, Nancy Vera, Susana Borkosky   +7 more
openaire   +3 more sources

Experimental infection of Lutzomyia longipalpis fed on a patient with cutaneous leishmaniasis due to Leishmania mexicana amazonensis

Memorias do Instituto Oswaldo Cruz, 1986
The authors were able to infect phlebotomine sandflies on a human case of American Cutaneous Leishmaniasis by feeding females of Lutzomyia longipalpis on a patient with a lesion due to Leishmania mexicana amazonensis.Os autores lograram infectar ...
Leonidas M. Deane, Elizabeth Ferreira Rangel, Manoel Paes-Oliveira, Gabriel Grimaldi Junior, Hooman Momen, Nataly de Souza, Eduardo D. Wermelinger, André F. Barbosa   +7 more
doaj   +1 more source

Evaluation of Uliginosin B as a Modulator of the Ras Pathway: In Vivo Evidence From Caenorhabditis elegans and In Silico Insights

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
This study performs in vivo and in silico assays with uliginosin B, targeting its activity in the Ras signaling pathway, demonstrating a possible allosteric interaction with the HRAS (human) and LET‐60 (nematode) proteins, and a decrease in the overexpression of the let‐60 gene in the nematode C. elegans.
Maria Eduarda O. De Souza, Flávia Suelen De O. Pereira, Daniela Teixeira Rodrigues, Helder Dias Costa, Tarsila Dantas Da Rosa, Camila Machado Pires da Silva, Gilsane von Poser, Stela M. K. Rates, Favero R. Paula, Daiana Silva Ávila   +9 more
wiley   +1 more source