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Leishmaniasis is an anthropozoonotic disease, and dogs are considered the main urban reservoir of the parasite. Macrophages, the target cells of Leishmania sp., play an important role during infection.
Natalia Rocha Nadaes +11 more
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As leishmanioses são zoonoses endêmicas em Mato Grosso do Sul e têm por agentes etiológicos nessa região Leishmania (Leishmania) chagasi, Leishmania (Leishmania) amazonensis e Leishmania (Viannia) braziliensis.
Manoel Sebastião da Costa Lima Junior +5 more
doaj +1 more source
New therapeutic alternatives against leishmaniasis remain a priority. The activity of azithromycin against Leishmania (Leishmania) major has been previously demonstrated.
Ángel Sinagra +5 more
doaj +1 more source
Experimental infection and transmission of Leishmania by Lutzomyia cruzi (Diptera: Psychodidae): Aspects of the ecology of parasite-vector interactions. [PDF]
Several parameters should be addressed before incriminating a vector for Leishmania transmission. Those may include its ability to become infected by the same Leishmania species found in humans, the degree of attractiveness for reservoirs and humans and ...
Everton Falcão de Oliveira +7 more
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Intracellular phagosomal pathogens represent a formidable challenge for innate immune cells, as, paradoxically, these phagocytic cells can act as both host cells that support pathogen replication and, when properly activated, are the critical cells that ...
Matheus B. Carneiro, Nathan C. Peters
doaj +1 more source
The role of surface glycoconjugates in Leishmania midgut attachment examined by competitive binding assays and experimental development in sand flies [PDF]
SUMMARY Binding of promastigotes to the sand fly midgut epithelium is regarded as an essential part of the Leishmania life cycle in the vector. Among Leishmania surface molecules putatively involved in attachment to the sand fly midgut, two GPI-anchored ...
Jecna, Lucie +13 more
core +1 more source
Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals.
Wilson Mayrink +6 more
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Background: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice.
Herintha Coeto Neitzke-Abreu +9 more
doaj
Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate. [PDF]
Au cours de la dernière décennie, la résistance aux antimoniaux est devenue un problème grave en raison de l'émergence de souches pharmacorésistantes. Par conséquent, il est essentiel de comprendre les mécanismes utilisés par les parasites Leishmania pour survivre sous la pression des médicaments, en particulier pour les espèces d'importance médico ...
Patino LH, Muskus C, Ramírez JD.
europepmc +5 more sources
Role of Leishmania (Leishmania) amazonensis amastigote glycosphingolipids in macrophage infectivity [PDF]
The role of glycosphingolipids (GSLs) present in amastigote forms of Leishmania (Leishmania) amazonensis during infection of macrophages was analyzed, with particular emphasis on GSLs presenting the terminal Galpss1-3Galpa disaccharide. Macrophage invasion by L.
Tanaka, Améria Kaori UNIFESP +3 more
openaire +6 more sources

