Results 81 to 90 of about 66,437 (256)

Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination

Microorganisms, 2021
Leishmania, an intracellular parasite species, causes lesions on the skin and in the mucosa and internal organs. The dissemination of infected host cells containing Leishmania is crucial to parasite survival and the establishment of infection.
Amanda Rebouças, Thaílla S. Silva, Lilian S. Medina, Bruno D. Paredes, Luciana S. Aragão, Bruno S. F. Souza, Valéria M. Borges, Albert Schriefer, Patricia S. T. Veras, Claudia I. Brodskyn, Juliana P. B. de Menezes   +10 more
doaj   +1 more source

In Vitro Screening Test Using Leishmania Promastigotes Stably Expressing mCherry Protein [PDF]

, 2014
Transgenic Leishmania major and Leishmania donovani axenic promastigotes constitutively expressing mCherry were used for in vitro antileishmanial drug screening. This method requires minimal sample manipulation and can be easily adapted to automatic drug
Miguel A. Morales, Vacchina, Paola
core   +2 more sources

Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection.

Food Chemistry, 2013
Fisetin, quercetin, luteolin and 7,8-hydroxyflavone show high activity in Leishmania cultures and present low toxicity to mammalian cells. In this work, the structural aspects of 13 flavonoids were analyzed for their inhibition of the arginase enzyme ...
Letícia Correa Manjolin, Matheus Balduíno Goncalves dos Reis, C. C. Maquiaveli, O. Santos-Filho, E. R. da Silva   +4 more
semanticscholar   +1 more source

Developing giant plasma membrane vesicles from Leishmania cells to investigate the role of membrane proteins in photodynamic inactivation

Photochemistry and Photobiology, Volume 102, Issue 2, Page 480-488, March/April 2026.
In this study, we developed giant plasma membrane vesicles (GPMVs) from Leishmania amazonensis promastigote membranes to investigate the role of protein‐embedded membranes in methylene blue (MB) photooxidation. Upon MB photoactivation in model lipid membranes (giant unilamellar vesicles, GUVs), a distinct photooxidation effect was observed, marked by ...
Maressa D. F. de Souza, Pietro Ciancaglini, Rosangela Itri, Martha S. Ribeiro   +3 more
wiley   +1 more source

Antileishmanial activity and evaluation of the mechanism of action of strychnobiflavone flavonoid isolated from Strychnos pseudoquina against Leishmania infantum [PDF]

, 2016
© 2015, Springer-Verlag Berlin Heidelberg. The present study aimed to investigate the in vitro antileishmanial activity of strychnobiflavone flavonoid against Leishmania infantum, as well as its mechanism of action, and evaluate the ex vivo ...
Coelho, Eduardo A. F., Lage, Paula S., Soto, Manuel   +2 more
core   +1 more source

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

Fusion between Leishmania amazonensis and Leishmania major parasitophorous vacuoles: live imaging of coinfected macrophages. [PDF]

PLoS Neglected Tropical Diseases, 2010
Protozoan parasites of the genus Leishmania alternate between flagellated, elongated extracellular promastigotes found in insect vectors, and round-shaped amastigotes enclosed in phagolysosome-like Parasitophorous Vacuoles (PVs) of infected mammalian ...
Fernando Real, Renato A Mortara, Michel Rabinovitch   +2 more
doaj   +1 more source

Sequence analysis of the 3-untranslated region of HSP70 (type I) genes in the genus Leishmania: Its usefulness as a molecular marker for species identification [PDF]

, 2015
Background: The Leishmaniases are a group of clinically diverse diseases caused by parasites of the genus Leishmania. To distinguish between species is crucial for correct diagnosis and prognosis as well as for treatment decisions.
Cañavate, Carmen, Chicharro, Carmen, García, Lineth, Parrado, Rudy, Puerta, Concepción J., Requena, José María   +5 more
core   +1 more source

Organic Light‐Emitting Diode in Phototherapy Applications

Advanced Photonics Research, Volume 7, Issue 2, February 2026.
This article systematically reviews the development of organic light‐emitting diodes (OLEDs) in phototherapy, constructs a technical framework, and establishes a multidimensional knowledge graph encompassing indications, wavelengths, and light intensity.
Yingguang Zhu, Yonglan Hu, Yingjie Cui, Lixue Guo, Guohui Zhang, Haixia Qiu, Defu Chen, Changyong Pan, Huijuan Yin, Suling Zhao   +9 more
wiley   +1 more source

Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes

Memorias do Instituto Oswaldo Cruz, 2011
In the current study, we evaluated the mechanism of action of miltefosine, which is the first effective and safe oral treatment for visceral leishmaniasis, in Leishmania amazonensis promastigotes.
Fernanda de Aquino Marinho, Keyla Cristiny da Silva Gonçalves, Selma Soares de Oliveira, Ana-Carolina de Siqueira Couto de Oliveira, Maria Bellio, Claudia Masini d'Avila-Levy, André Luis Souza dos Santos, Marta Helena Branquinha   +7 more
doaj   +1 more source