Results 1 to 10 of about 76,622 (282)

Self-Hybridization in Leishmania major

mBio, 2022
Genetic exchange between different Leishmania strains in the sand fly vector has been experimentally demonstrated and is supported by population genetic studies.
Tiago R. Ferreira, Ehud Inbar, Jahangheer Shaik, Brendan M. Jeffrey, Kashinath Ghosh, Deborah E. Dobson, Stephen M. Beverley, David Sacks   +7 more
doaj   +4 more sources

Evaluation of the Paraquat Effect on Leishmania major Promastigotes and HUVECs Viability under in vitro Condition

Journal of Ardabil University of Medical Sciences, 2019
Background & objectives: Pentavalent antimonials are the first-line drugs for treatment of leishmaniasis, which have multiple side effects such as drug toxicity. Moreover, parasite resistance to these drugs is rising around the world.
Ali Niapour, Keyvan Amirshahrokhi, Mohammad Azari Rad, Behnam Mohammadi-ghalehbin B   +3 more
doaj   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
A Debrabant, A Dube, A Mehta, A Mukherjee, AB Sidhu, AC Coelho, AH Fairlamb, Ashutosh, B Gourbal, B Vergnes, Basudha Khanal, BJ Mookerjee, C Brochu, C Dumas, CS Ferreira, D Legare, DM Weinreich, F Chappuis, F Frezard, G Mandal, Graham H. Coombs, H Denton, H Shim, Hideo Imamura, HW Murray, J Alvar, J Hellemans, J Mikus, J Tovar, JC Mottram, JC Munday, Jean-Claude Dujardin, JM Kelly, K Ait-Oudhia, K Grondin, KC Carter, Kirstyn Brunker, KW Tintaya, L Flohe, M Maharjan, M Samant, M Vanaerschot, Manu Vanaerschot, MK Mittal, ML Cunningham, MR Ariyanayagam, MR Perry, N Beerenwinkel, N Singh, N Van Meirvenne, P Baiocco, PJ Alcolea, PR Romao, R Hadighi, R Lira, R Mukhopadhyay, R Rojas, R Singh, RA Williams, RI da Luz, RL Krauth-Siegel, RL Krauth-Siegel, S Borrell, S Decuypere, S Dey, S Gagneux, S Mandal, S Muller, S Rais, S Rijal, S Sundar, S Wyllie, S Wyllie, S Yan, S Yan, Saskia Decuypere, Suman Rijal, Sylke Müller, T Downing, T Downing, T Laurent, T Nozaki, Timothy G. Geary, V Adaui, V Yardley, Y Zhou   +85 more
core   +16 more sources

The in vitro anti-Leishmania Effect of Zingiber officinale Extract on Promastigotes and Amastigotes of Leishmania major and Leishmania tropica

Türkiye Parazitoloji Dergisi, 2022
Objective:Recently, the use of pentavalent antimony compounds for Leishmaniasis treatment has been associated with disease recurrence, drug resistance, and severe side effects. Therefore, there is a need to develop alternative treatment strategies.
Jasem Saki, Elaheh Biranvand, Reza Arjmand   +2 more
doaj   +1 more source

PCR Positivity of Gerbils and Their Ectoparasites for Leishmania Spp. in a Hyperendemic Focus of Zoonotic Cutaneous Leishmaniasis in Central Iran

Journal of Arthropod-Borne Diseases, 2023
Background: Various arthropods, including Rhipicephalus sanguineus and Ctenocephalides felis felis have been sug­gested as secondary vectors of Leishmania spp. many years ago. This study was conducted to determine zoonotic cuta­neous leishmaniasis (ZCL)
Sahar Azarmi, Alireza Zahraei-Ramazani, Mehdi Mohebali, Yavar Rassi, Amir Ahmad Akhavan, Amrollah Azarm, Omid Dehghan, Samira Elikaee, Rahimeh Abdoli, Mohsen Mahmoudi   +9 more
doaj   +1 more source

Elimination of LRVs Elicits Different Responses in Leishmania spp.

mSphere, 2022
Leishmaniaviruses (LRVs) have been demonstrated to enhance progression of leishmaniasis, a vector-transmitted disease with a wide range of clinical manifestations that is caused by flagellates of the genus Leishmania.
Andreu Saura, Alexandra Zakharova, Donnamae Klocek, Evgeny S. Gerasimov, Anzhelika Butenko, Diego H. Macedo, Elena Servienė, Diana Zagirova, Anastasia Meshcheryakova, Igor B. Rogozin, Saulius Serva, Alexei Yu. Kostygov, Vyacheslav Yurchenko   +12 more
doaj   +1 more source

Molecular Identification of Cutaneous Leishmaniasis Species in the Northcentral Iranian Province of Alborz: Is There a New Focus on Cutaneous Leishmaniasis in the Province?

Iranian Journal of Parasitology, 2023
Background: Cutaneous leishmaniasis (CL) is an endemic infection in the Middle East, including Iran that is also spreading to new foci. We aimed to determine the leishmaniasis species causing CL in Alborz province.
Susan Sheikhi, Aliehsan Heidari, Mehdi Mohebali, Hossein Keshavarz, Amir Heidari, Monireh Sezavar, Behnaz Akhoundi, Amir Bairami   +7 more
doaj   +1 more source

The first detection of Leishmania major in naturally infected Sergentomyia minuta in Portugal [PDF]

, 2013
Phlebotomine sandflies of the genus Sergentomyia are widely distributed throughout the Old World. It has been suggested that Sergentomyia spp are involved in the transmission of Leishmania in India and Africa, whereas Phlebotomus spp are thought to be ...
Afonso, Maria Odete, Campino, Lenea, Cortes, Sofia, Dionisio, Lidia, Maia, Carla, Neto, Luis   +5 more
core   +3 more sources

Anti-Leishmanial Activity of Artemisia persica, A. spicigera, and A. fragrance against Leishmania major

Iranian Journal of Parasitology, 2021
Background: Neglected tropical diseases (NTDs) like zoonotic cutaneous leishmaniasis (ZCL), is a widespread infectious disease with high mortality and morbidity.
Mehdi Najm, Ramtin Hadighi, Maryam Heidari-Kharaji, Maryam Alipour, Maryam Hajizadeh, Raheleh Rafiei Sefiddashti, Aliehsan Heidari, Alireza Badirzadeh   +7 more
doaj   +1 more source

In Vitro Screening Test Using Leishmania Promastigotes Stably Expressing mCherry Protein [PDF]

, 2014
Transgenic Leishmania major and Leishmania donovani axenic promastigotes constitutively expressing mCherry were used for in vitro antileishmanial drug screening. This method requires minimal sample manipulation and can be easily adapted to automatic drug
Miguel A. Morales, Vacchina, Paola
core   +2 more sources