Results 1 to 10 of about 5,616,372 (322)

Self-Hybridization in Leishmania major

mBio, 2022
Genetic exchange between different Leishmania strains in the sand fly vector has been experimentally demonstrated and is supported by population genetic studies.
Tiago R. Ferreira, Ehud Inbar, Jahangheer Shaik, Brendan M. Jeffrey, Kashinath Ghosh, Deborah E. Dobson, Stephen M. Beverley, David Sacks   +7 more
doaj   +5 more sources

Analysis by RNA-seq of transcriptomic changes elicited by heat shock in Leishmania major [PDF]

Scientific Reports, 2019
Besides their medical relevance, Leishmania is an adequate model for studying post-transcriptional mechanisms of gene expression. In this microorganism, mRNA degradation/stabilization mechanisms together with translational control and post-translational ...
Aguado, Begoña, Corvo, Laura, Lombraña, Rodrigo, Rastrojo, Alberto, Requena, Jose M., Solana, Jose C.   +5 more
core   +3 more sources

Metabolomics to unveil and understand phenotypic diversity between pathogen populations [PDF]

, 2010
Visceral leishmaniasis is caused by a parasite called Leishmania donovani, which every year infects about half a million people and claims several thousand lives. Existing treatments are now becoming less effective due to the emergence of drug resistance.
A Kamleh, A Scalbert, AK Chavali, Andris Jankevics, BO Keller, C Bern, C Christin, CC HsuChen, D Kumar, David G. Watson, DS Wishart, E Cauchetier, E Fahy, F Chappuis, F Hong, FR Opperdoes, G Barratt, Graham H. Coombs, H Ogata, HC Maltezou, HJ Atherton, HP de Koning, HW Murray, J Alvar, J Trygg, J Vandesompele, JC Mottram, Jean-Claude Dujardin, JV Olsen, K Zhang, K Zhang, Kirstyn Brunker, KW Tintaya, M Basselin, M Basselin, M Rakotomanga, MA Basinger, MA Doyle, MA Kamleh, MA Kamleh, MB Eisen, MK Wassef, MZ Alam, N Mbongo, N Van Meirvenne, R Breitling, R Breitling, R Breitling, RA Scheltema, RA Scheltema, RA Scheltema, Rainer Breitling, Richard A. Scheltema, Ruben t'Kindt, S Rijal, S Sundar, Saskia Decuypere, Suman Rijal, T Laurent, T Naderer, Timothy G. Geary, VP Shah, W Windig, WB Dunn   +63 more
core   +16 more sources

The role of Leishmania GP63 in the modulation of innate inflammatory response to Leishmania major infection

PLoS ONE, 2021
Leishmaniasis is a disease caused by the protozoan parasite Leishmania and is known to affect millions of individuals worldwide. In recent years, we have established the critical role played by Leishmania zinc-metalloprotease GP63 in the modulation of ...
Aretha Chan, Jose-Mauricio Ayala, F. Alvarez, C. Piccirillo, G. Dong, D. Langlais, M. Olivier   +6 more
semanticscholar   +1 more source

The in vitro anti-Leishmania Effect of Zingiber officinale Extract on Promastigotes and Amastigotes of Leishmania major and Leishmania tropica

Türkiye Parazitoloji Dergisi, 2022
Objective:Recently, the use of pentavalent antimony compounds for Leishmaniasis treatment has been associated with disease recurrence, drug resistance, and severe side effects. Therefore, there is a need to develop alternative treatment strategies.
Jasem Saki, Elaheh Biranvand, Reza Arjmand   +2 more
doaj   +1 more source

Recombinase-based amplification coupled with lateral flow chromatography for the specific and sensitive detection and identification of Leishmania major in cutaneous leishmaniasis patients. [PDF]

Front Microbiol
Bel Hadj Ali I, Saadi-Ben Aoun Y, Khammeri I, Souguir H, Harigua-Souiai E, Chouaieb H, Chakroun AS, Lemrani M, Kallel A, Kallel K, Haddad N, El Dbouni O, Coler RN, Reed SG, Fathallah-Mili A, Guizani I.   +15 more
europepmc   +3 more sources

PCR Positivity of Gerbils and Their Ectoparasites for Leishmania Spp. in a Hyperendemic Focus of Zoonotic Cutaneous Leishmaniasis in Central Iran

Journal of Arthropod-Borne Diseases, 2023
Background: Various arthropods, including Rhipicephalus sanguineus and Ctenocephalides felis felis have been sug­gested as secondary vectors of Leishmania spp. many years ago. This study was conducted to determine zoonotic cuta­neous leishmaniasis (ZCL)
Sahar Azarmi, Alireza Zahraei-Ramazani, Mehdi Mohebali, Yavar Rassi, Amir Ahmad Akhavan, Amrollah Azarm, Omid Dehghan, Samira Elikaee, Rahimeh Abdoli, Mohsen Mahmoudi   +9 more
doaj   +1 more source

A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing

Nature Communications, 2020
Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa transmitted by infected sand flies. Vaccination through leishmanization with live Leishmania major has been used successfully but is no longer practiced because it resulted in ...
Wen Wei Zhang, S. Karmakar, Sreenivas Gannavaram, R. Dey, Patrick Lypaczewski, Nevien Ismail, A. Siddiqui, V. Simonyan, Fabiano Oliveira, Iliano V. Coutinho-Abreu, Thiago DeSouza-Vieira, C. Meneses, James Oristian, T. D. Serafim, Abu Musa, R. Nakamura, N. Saljoughian, Greta Volpedo, Monika Satoskar, Monika Satoskar, S. Satoskar, S. Satoskar, Pradeep K. Dagur, J. McCoy, S. Kamhawi, J. Valenzuela, S. Hamano, A. Satoskar, G. Matlashewski, H. Nakhasi   +29 more
semanticscholar   +1 more source

Evaluation of the Paraquat Effect on Leishmania major Promastigotes and HUVECs Viability under in vitro Condition

Journal of Ardabil University of Medical Sciences, 2019
Background & objectives: Pentavalent antimonials are the first-line drugs for treatment of leishmaniasis, which have multiple side effects such as drug toxicity. Moreover, parasite resistance to these drugs is rising around the world.
Ali Niapour, Keyvan Amirshahrokhi, Mohammad Azari Rad, Behnam Mohammadi-ghalehbin B   +3 more
doaj   +1 more source

Elimination of LRVs Elicits Different Responses in Leishmania spp.

mSphere, 2022
Leishmaniaviruses (LRVs) have been demonstrated to enhance progression of leishmaniasis, a vector-transmitted disease with a wide range of clinical manifestations that is caused by flagellates of the genus Leishmania.
Andreu Saura, Alexandra Zakharova, Donnamae Klocek, Evgeny S. Gerasimov, Anzhelika Butenko, Diego H. Macedo, Elena Servienė, Diana Zagirova, Anastasia Meshcheryakova, Igor B. Rogozin, Saulius Serva, Alexei Yu. Kostygov, Vyacheslav Yurchenko   +12 more
doaj   +1 more source