Results 61 to 70 of about 36,816 (193)
Protein Science, Volume 35, Issue 9, September 2026.Abstract The nucleoside diphosphate kinase (NDK) is a key enzyme that controls the balance of nucleotide pools in all living organisms. Beyond this fundamental role, NDKs exert pleiotropic effects in many cellular processes, including cell development, signal transduction, differentiation, tumor metastasis, and gene expression. The quaternary structure
Julie Kerboeuf +10 more
wiley +1 more source
Iranian Journal of Public Health, 2019 Background: The aims of the current study were to determined present status of CL in Shiraz City, identify the causative species of Leishmania and conduct phylogenetic evaluations in detected parasites Methods: This study was conducted on 70 ...
Aliyar MIRZAPOUR +7 more
doaj +1 more source
Oligopeptidase B deficient mutants of Leishmania major [PDF]
Molecular and Biochemical Parasitology, 2011 Oligopeptidase B is a clan SC, family S9 serine peptidase found in gram positive bacteria, plants and trypanosomatids. Evidence suggests it is a virulence factor and thus therapeutic target in both Trypanosoma cruzi and T. brucei, but little is known about its function in Leishmania. In this study L.
Munday, Jane C. +4 more
openaire +4 more sources
Evolutionary insights into bilin biosynthesis: Functional characterization of pre‐PcyA enzymes
Protein Science, Volume 35, Issue 9, September 2026.Abstract Biosynthesis of the linear tetrapyrrole phycocyanobilin (PCB) by the ferredoxin‐dependent bilin reductase (FDBR) PcyA is essential for light‐harvesting and regulatory processes in diverse photosynthetic organisms, yet its evolutionary origins are not fully understood. PcyA evolved from pre‐PcyA proteins found in diverse bacteria.
Federica Frascogna +3 more
wiley +1 more source
The immunology of susceptibility and resistance to Leishmania major in mice [PDF]
Nature Reviews Immunology, 2002 Established models of T-helper-2-cell dominance in BALB/c mice infected with Leishmania major -- involving the early production of interleukin-4 by a small subset of Leishmania-specific CD4+ T cells -- have been refined by accumulating evidence that this response is not sufficient and, under some circumstances, not required to promote susceptibility ...
David, Sacks, Nancy, Noben-Trauth
openaire +2 more sources
ChemBioChem, Volume 27, Issue 15, 14 August 2026.Organometallic derivatization of existing drugs is a common strategy to look for new drug candidates. This work describes the derivatization of the benzimidazole anthelmintic scaffold, from the synthesis of the organometallic derivatives to the evaluation of their biological properties. It highlights a broad range of antiparasitic activities and leaves
Corentin Ludwig +14 more
wiley +1 more source
Actinomycin Derivatives: Structural Diversification and Biological Activities
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Bioactive metabolites can remain hidden in negligible activity extracts. A statistical spectroscopy–driven dereplication workflow integrating the HeteroCovariance Approach (HetCA) and Statistical Total Correlation Spectroscopy (STOCSY) prioritized furofuran lignans in Artemisia arborescens, identifying three compounds with moderate antileishmanial ...
Olga Karoutzou +6 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
Camila S. de Freitas +9 more
wiley +1 more source
Murine T Cell‐Dependent Response Affects Leishmania amazonensis Amastigote Survival and Virulence
Cell Biology International, Volume 50, Issue 8, August 2026.ABSTRACT Our group has previously described the infection course of Leishmania amazonensis in BALB/c and BALB/cnu/nu mice, which have distinct T‐cell dependent responses. In this study, lesion‐derived amastigotes exhibited differential protein expression in a host‐dependent manner.
Gustavo Henrique Corrêa Soares +2 more
wiley +1 more source