Results 61 to 70 of about 4,849,377 (223)

Predicting Mammal Species Suitable for Chagas Disease Spread Using a Machine‐Learning Framework

Integrative Zoology, EarlyView.
Chagas disease is maintained in wildlife by Trypanosoma cruzi cycling among many mammal species, but we still do not know the full range of potential hosts. Using machine learning and ecological/behavioral traits, we found that kissing bugs overlap with 573 mammal species and tend to feed on mammals that are den‐dwelling, medium‐to‐large in size, and ...
Maya Rocha‐Ortega, Carezza Botto‐Mahan, Gemma Rojo, Alex Córdoba‐Aguilar   +3 more
wiley   +1 more source

Clinical and Epidemiological Characteristics of Leishmania Species in Isfahan, Iran [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum
Background and Objectives: Leishmaniasis is a vector-borne disease that caused by kinetoplastid protozoa of the Leishmania genus. This study aims to investigate the clinical and epidemiologic characteristics of Leishmania species in patients with ...
Azadeh Zolfaghari, Keivan Beheshti-Maal, Ali Mohammad Ahadi, Ramesh Monajemi   +3 more
doaj  

La leishmaniose cutanée des steppes« Étude épidémiologique et typage des souches »

Avicenna Medical Research
La leishmaniose cutanée constitue un important problème de santé publique dans les régions arides et semi-arides d’Algérie, où les modifications environnementales et anthropiques favorisent l’expansion des foyers endémiques.
L Chorfi, K Abdelouahed, A-H Fendri
doaj   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

Leishmania isoenzyme polymorphisms in Ecuador: Relationships with geographic distribution and clinical presentation [PDF]

, 2006
Background: Determinants of the clinical presentation of the leishmaniases are poorly understood but Leishmania species and strain differences are important.
Cooper Philip J, Masataka Korenaga, Marco Jorge D, Korenaga, Masataka, Rodrigo X Armijos, Hirotomo Kato, Paola A Barroso, Kato Hirotomo, Korenaga, M, Gomez, EA, Calvopina Manuel, Kato, Hirotomo, Hiroshi Uezato, Barroso, Paola A., Armijos, Rodrigo X., Cooper, PJ, Yoshihisa Hashiguchi, Shigeo Nonaka, Nonaka Shigeo, Gomez Eduardo A, Manuel Calvopina, Marco, Jorge D., Kato, H, Barroso Paola A, Mimori, Tatsuyuki, Armijos, RX, Hashiguchi, Y, Nonaka, Shigeo, Eduardo A Gomez, Calvopina, M, Marco, JD, Korenaga Masataka, Tatsuyuki Mimori, Uezato, H, Jorge D Marco, Gomez, Eduardo A., Calvopina, Manuel, Mimori Tatsuyuki, Manuel Calvopina, Uezato Hiroshi, Cooper, Philip J., Hashiguchi, Yoshihisa, Mimori, T, Philip J Cooper, Nonaka, S, Uezato, Hiroshi, Armijos Rodrigo X, Barroso, PA, Hashiguchi Yoshihisa   +48 more
core   +2 more sources

A dhfr-ts- Leishmania major Knockout Mutant Cross-protects against Leishmania amazonensis

Memorias do Instituto Oswaldo Cruz, 1999
E10-5A3 is a dhfr-ts- Leishmania major double knockout auxotrophic shown previously to induce substantial protection against virulent L. major infection in both genetically susceptible and resistant mice.
PST Veras, CI Brodskyn, FMP Balestieri, LAR de Freitas, APS Ramos, ARP Queiroz, A Barral, SM Beverley, M Barral-Netto   +8 more
doaj   +1 more source

From productive coupling to catalytic commitment: An evolutionarily tuned interdomain connector in Leishmania Aha1 orchestrates Hsp90 activation

The FEBS Journal, EarlyView.
LbAha1 activates LbHsp90 through a multistep mechanism in which productive N‐domain docking precedes ATP‐driven rearrangement and linker ordering. The LbAha1 linker transitions from a flexible to helical state, stabilizing an asymmetric, catalytically competent closed complex.
Paulo Roberto Dores‐Silva, Thiago Vargas Seraphim, Karine Minari, Izabella Rodrigues Fonseca da Silva, Winston Pinheiro Claro Gomes, Leijiane Figueira de Sousa, Arthur Moraes Franco da Rocha, Leandro Ramos Souza Barbosa, Jeremiah Stanson Joseph, Júlio César Borges   +9 more
wiley   +1 more source

Cinnamic Acid Bornyl Ester Derivatives from Valeriana wallichii Exhibit Antileishmanial In Vivo Activity in Leishmania major-Infected BALB/c Mice. [PDF]

PLoS ONE, 2015
Human leishmaniasis covers a broad spectrum of clinical manifestations ranging from self-healing cutaneous leishmaniasis to severe and lethal visceral leishmaniasis caused among other species by Leishmania major or Leishmania donovani, respectively. Some
Anita Masic, Ana Maria Valencia Hernandez, Sudipta Hazra, Jan Glaser, Ulrike Holzgrabe, Banasri Hazra, Uta Schurigt   +6 more
doaj   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Prevalence of Leishmania species among patients with cutaneous leishmaniasis in Qassim province of Saudi Arabia

BMC Public Health, 2019
Background Leishmaniasis is a parasitic infection endemic in more than ninety countries of the world. The cutaneous leishmaniasis (CL) is a most common form of leishmaniasis and it remains to be a major public health issue in Saudi Arabia. This study was
Zafar Rasheed, Ahmed A. Ahmed, Tarek Salem, Mohammed S. Al-Dhubaibi, Ahmad A. Al Robaee, Abdullateef A. Alzolibani   +5 more
doaj   +1 more source